DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Moe and NF2

DIOPT Version :9

Sequence 1:	NP_727290.1	Gene:	Moe / 31816	FlyBaseID:	FBgn0011661	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_000259.1	Gene:	NF2 / 4771	HGNCID:	7773	Length:	595	Species:	Homo sapiens

Alignment Length:	647	Identity:	273/647 - (42%)
Similarity:	385/647 - (59%)	Gaps:	79/647 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SVKR---KTLNVRVTTMDAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIK 79
            |:||   ||..||:.|||||:||..:....||.|||.|.:|:||||.|||||||| .|....|:|
Human    13 SLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLK 76

  Fly    80 LYKKPESPAIKTIKYLKRVKKYVDKKTADSNGVNHLETSEEDDDADDMTGSMPFSTWVMNQDVKK 144
            :.||                                                     |::.||.|
Human    77 MDKK-----------------------------------------------------VLDHDVSK 88

  Fly   145 ENPLQFRFRAKFYPEDVAEELIQDITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDH 209
            |.|:.|.|.||||||:..|||:|:||..||:||||..||.::||||||.|||||||||||::||:
Human    89 EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDY 153

  Fly   210 NKTTHTAGFLANDRLLPQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYG 274
            :.:.|..||||.:.|||:|||:.::|:.:.||:.|..|:.|||...|::|.||||||||||||||
Human   154 DPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYG 218

  Fly   275 VNYFEIRNKKGTDLWLGVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDF 339
            ||||.|||||||:|.||||||||:||:.::||||||.|||:||||||:|:|:|.|||:|||...|
Human   219 VNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVF 283

  Fly   340 MFFAPRVRINKRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQEREKLQLALAARER 404
            .|.:.::|:||.||.||:|||:|:|||||.|:::||||||||||||..||.||::|......||.
Human   284 KFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREE 348

  Fly   405 AEKKQQEYEDRLKQMQEDMERSQRDLLEAQDMIRRL-------EEQLKQLQAAKDELELRQKELQ 462
            ||:.:.|.|.||.||:|:...:...|:.:::....|       ||:.|.|.....|.|...:.::
Human   349 AERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIK 413

  Fly   463 AMLQRLEEAKNMEAVEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVEDARRKQVIAAEA 527
            |...|.||.|.:  :|:..||.|::|.:|     .:|...:.:|..:|:.::::||..:   ..|
Human   414 ATAIRTEEEKRL--MEQKVLEAEVLALKM-----AEESERRAKEADQLKQDLQEAREAE---RRA 468

  Fly   528 AAALLAASTTPQHHHVAEDENENEEELTNGDAGGD-VSRDL-DTD-EHIKDPIEDRRT-LAERNE 588
            ...||..:|.|.:..:.........::.:.:..|| :|.|. ||| :.:...||..:. ..|:::
Human   469 KQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSK 533

  Fly   589 RLHDQLKALKQDLAQSRDETKETANDKIHRENV-RQGRDKYKTLREIRKGNTKRRVDQFENM 649
            .|.:||..||.::...:.:.:|||.|.:|.||. |.|..|:.|::::...:.|.||..||.:
Human   534 HLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604	117/251 (47%)
		FERM_N	28..83	CDD:286467	29/54 (54%)
		FERM_M	163..278	CDD:278785	70/114 (61%)
		FERM_C_ERM	272..368	CDD:270015	65/95 (68%)
		GBP_C	<375..497	CDD:303769	46/128 (36%)
		ERM	403..649	CDD:279153	70/257 (27%)
		coiled coil	464..477	CDD:293879	4/12 (33%)
		coiled coil	486..497	CDD:293879	2/10 (20%)
NF2	NP_000259.1	B41	23..222	CDD:214604	117/252 (46%)
		FERM_C_ERM	216..312	CDD:270015	65/95 (68%)
		PLN03086	307..>367	CDD:178635	34/59 (58%)
		ERM	347..595	CDD:366293	70/257 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281811at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820