Protein Alignment Moe and MSN

DIOPT Version :10

• Sequence 1: NP_727290.1
• Gene: Moe / 31816
• FlyBaseID: FBgn0011661
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_011529261.1
• Gene: MSN / 4478
• HGNCID: 7373
• Length: 610
• Species: Homo sapiens
• Alignment Length: 644
• Identity: 358/644 - (55%)
• Similarity: 457/644 - (70%)
• Gaps: 89/644 - (13%)

  Fly    24 LNVRVTTMDAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIKLYKKPESPA 88
            ::|||||||||||||||..||||||||||||||||||||||||||.|:||.|||:||.||
Human    38 ISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKK----- 97

  Fly    89 IKTIKYLKRVKKYVDKKTADSNGVNHLETSEEDDDADDMTGSMPFSTWVMNQDVKKENPLQFRFR 153
                                                            |..|||:||:||.|:||
Human    98 ------------------------------------------------VTAQDVRKESPLLFKFR 114

  Fly   154 AKFYPEDVAEELIQDITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDHNKTTHTAGF 218
            ||||||||:||||||||.|||:||||..||.|:|||||||:|||||||||:::||.||..|.:|:
Human   115 AKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSKYGDFNKEVHKSGY 179

  Fly   219 LANDRLLPQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYGVNYFEIRNK 283
            ||.|:||||||::|||::||:||:.|..|.:|||.||||||::|||||||||||||||||.|:||
Human   180 LAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQDLEMYGVNYFSIKNK 244

  Fly   284 KGTDLWLGVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDFMFFAPRVRI 348
            ||::|||||||||||||||:|||||||||||||||||||::|||:|||||||||||:|:|||:||
Human   245 KGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRI 309

  Fly   349 NKRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQER-------EKLQLALAARERAE 406
            ||||||||||||||||||||||||:||||||||||||:.||.||       :|.::|...:|:.|
Human   310 NKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIE 374

  Fly   407 KKQQEYEDRLKQMQEDMERSQRDLLEAQDMIRRLEEQLKQLQAAKDELELRQKEL----QAMLQR 467
            ::::|..:||||::|..:::|::|.|.......||::.|:.|:..::|...::|.    :|:||.
Human   375 REKEELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQA 439

  Fly   468 LEEAKNMEAVEKLKLE-EEIMAK--QMEVQRIQDEVNAKD--EETKRLQDEVEDARRKQVIAAEA 527
            ..:.|..:  |:|.|| .|:.|:  |:|:.|.:.|..|.:  ::.:.:|:::|..|
Human   440 SRDQKKTQ--EQLALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTR--------- 493

  Fly   528 AAALLAASTTPQHHHVAED-ENENEEELTNGDAGGDVSRDLDTDEHIKDPIEDRRTL-AERNERL 590
             |.|..|.:||   ||||. |||.:|:..|   |.:.|.||..|...||..|:.||. ||:|||:
Human   494 -AELKTAMSTP---HVAEPAENEQDEQDEN---GAEASADLRADAMAKDRSEEERTTEAEKNERV 551

  Fly   591 HDQLKALKQDLAQSRDETKETANDKIHRENVRQGRDKYKTLREIRKGNTKRRVDQFENM 649
            ...||||..:||.:|||:|:||||.||.||:|.|||||||||:||:||||:|:|:||:|
Human   552 QKHLKALTSELANARDESKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604	152/251 (61%)
		FERM_C_ERM	272..368	CDD:270015	84/95 (88%)
		ERM_helical	402..521	CDD:466641	35/127 (28%)
		ERM_C	573..649	CDD:459932	48/76 (63%)
MSN	XP_011529261.1	B41	40..239	CDD:214604	152/251 (61%)
		FERM_C_ERM	233..329	CDD:270015	84/95 (88%)
		ERM_helical	380..489	CDD:466641	30/110 (27%)
		ERM_C	535..610	CDD:459932	47/74 (64%)