DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Moe and Frmd7

DIOPT Version :9

Sequence 1:	NP_727290.1	Gene:	Moe / 31816	FlyBaseID:	FBgn0011661	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001177261.1	Gene:	Frmd7 / 385354	MGIID:	2686379	Length:	703	Species:	Mus musculus

Alignment Length:	659	Identity:	140/659 - (21%)
Similarity:	248/659 - (37%)	Gaps:	169/659 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LNVRVTTM-DAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIKLYKKPESP 87
            |:::|..: |::..|.:...::||.||:.....:.|.|..:|||::....|::.|::|.|    |
Mouse     2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCGHLNLAEKEYFGLEFCSHSGNNVWLELLK----P 62

  Fly    88 AIKTIKYLKRVKKYVDKKTADSNGVNHLETSEEDDDADDMTGSMPFSTWVMNQDVKKENPLQFRF 152
            ..|.:|..|.|                                                  .|:|
Mouse    63 ITKQVKNPKEV--------------------------------------------------VFKF 77

  Fly   153 RAKFYPEDVAEELIQDITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGD-HNKTTHTA 216
            ..||:|.|.. .|.:::|..||.||:|..:....:.|....:.|:.|:.:|:..|| |.:|...
Mouse    78 MVKFFPVDPG-HLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEETVRK- 140

  Fly   217 GFLANDRLLPQRVIDQHKMSKDEWEQSIMTWWQEH--RSMLREDAMMEYLKIAQDLEMYGVNYFE 279
             .|...:.||         |:...|..||.:.|:|  ||....|.::  |.||:.|:|||:....
Mouse   141 -HLVQTQYLP---------SQASLESKIMQFHQQHIGRSPAESDILL--LDIARKLDMYGIRPQP 193

  Fly   280 IRNKKGTDLWLGVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDFMFFAP 344
            ..:.:|..:.|.|..:|:.:...:.::..   |.|::||.:||..|.|:||
Mouse   194 ASDGEGMQIHLAVAHMGVLVLRGNTKINT---FNWAKIRKLSFKRKHFLIK-------------- 241

  Fly   345 RVRINKRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNA----KQQEREKLQLALAAR--- 402
               ::..||.||....|..|..|     |..:...:...|.:|    .::.:.|.:..|.::
Mouse   242 ---LHANILVLCKDTLEFTMASR-----DACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSS 298

  Fly   403 ----ERAEKKQQEY--EDRLKQMQEDMERSQ-------RDLLEAQDMIRRLEEQLKQLQAAKDEL 454
                .|.:::..||  :.|||.:  ..||.|       |....:.|::..:.:|::.|:......
Mouse   299 FRYSGRTQRQLLEYGKKGRLKSL--PFERKQYPSQYHERQCRSSPDILSDVSKQVEDLRLTYGSS 361

  Fly   455 ELRQ-KELQAMLQRLEEAKNMEAVEKLKLEEEIMAKQMEVQRIQDEV------NAKDEETKRLQD 512
            ..|. ..:.|....|:..:...||      |...|.::|..:.:.|.      .:....|....|
Mouse   362 YYRNVNGVHASESMLDSRRRNSAV------EVTFAAELEHSKPEAEATSLHPSQSSSSFTFIYAD 420

  Fly   513 EVEDARRKQVIAAEAAAALLAASTTPQHHHVAEDENENEEELTNGDAG--GDVSRDLD------- 568
            .|.:...:.:...|..:.|.:..||.:.......:.....:||..|..  ...|:.:|
Mouse   421 PVFNTDPEPIEFFEERSPLSSFQTTSKFADSHTSKASPARQLTYTDVPYIPCTSQKVDIMPPQVF 485

  Fly   569 --TDEHIKDPIEDRRTL--AERNER-----------------LHDQLKALKQDLAQSRDETKETA 612
              .|   |.|...||:|  ||.|.|                 .:.::|:|:|||.:.::....|:
Mouse   486 FYVD---KPPQVPRRSLIMAEENMRPDSYVDHSAIKPAKRSPRNMRIKSLQQDLQELQEAMARTS 547

  Fly   613 NDKIHRENV 621
            .    |.|:
Mouse   548 G----RSNI 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604	61/255 (24%)
		FERM_N	28..83	CDD:286467	15/55 (27%)
		FERM_M	163..278	CDD:278785	34/117 (29%)
		FERM_C_ERM	272..368	CDD:270015	23/95 (24%)
		GBP_C	<375..497	CDD:303769	25/142 (18%)
		ERM	403..649	CDD:279153	52/265 (20%)
		coiled coil	464..477	CDD:293879	1/12 (8%)
		coiled coil	486..497	CDD:293879	2/10 (20%)
Frmd7	NP_001177261.1	FERM_F1_FRMD7	1..86	CDD:340708	27/137 (20%)
		FERM_M	85..191	CDD:366056	35/119 (29%)
		FERM_C_FARP1-like	179..299	CDD:270014	32/144 (22%)
		FA	294..330	CDD:370090	9/37 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810