DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Moe and mto1

DIOPT Version :9

Sequence 1:	NP_727290.1	Gene:	Moe / 31816	FlyBaseID:	FBgn0011661	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_588284.1	Gene:	mto1 / 2539467	PomBaseID:	SPCC417.07c	Length:	1115	Species:	Schizosaccharomyces pombe

Alignment Length:	679	Identity:	130/679 - (19%)
Similarity:	248/679 - (36%)	Gaps:	207/679 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LQYTDSKGDSTWIKLYKKPESPAI-----------KTIKYLKRVKKYVDKKTADSNGVNHLETSE 119
            ||.|..|.:..::.....|.:.|:           ..:|.||..|..:.|:..:|...:.|...|
pombe   189 LQLTPIKEERNYLHSQDAPTTNALSKKISDILIPASAMKDLKDRKNALAKEFEESQPGSSLTLKE 253

  Fly   120 EDDDADDM---TGSMPFSTWVMNQDVKKENPLQFRFRAKFYPEDVAEELIQDITLRLFYLQVKNA 181
            :.:..|::   ...:....:.:...:.           ||:.::|.:.:.|:|.|:...::::.|
pombe   254 QANVIDNLRKEVFGLKLKCYFLYDQLN-----------KFHDQEVQDIMKQNIDLKTLTMELQRA 307

  Fly   182 ILTDE-----------------IYCP---PETSVLLASYAVQA--------------RHGDHNKT 212
            :...|                 :..|   |...:.|.|...||              |.....||
pombe   308 VAGYEKKISGLESRIKPDQSFNLSTPSPAPSNLITLQSRYSQALSELETTKRAFAALRKEKSKKT 372

  Fly   213 THTAGFLANDRLLPQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYGVNY 277
            .::.|....||.:...::|..:..|:              ::|:|   :|.|::
pombe   373 NYSVGAYNEDRNVLSNMLDNERREKE--------------ALLQE---LESLRV----------- 409

  Fly   278 FEIRNK-----KGTD------LWLGVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKP 331
             ::..|     |.||      |....:.|.::|..|::.|.            :...|...::|.
pombe   410 -QLSKKVPMPAKNTDERVIETLQRSNELLRMDISMQNEALL------------LRKQENDRLVKQ 461

  Fly   332 IDKKAPDFMFFAPRVRIN----KRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQER 392
            :::..         |.:|    ..|:......:||:      |::.|.:||.|        :|..
pombe   462 VEELT---------VALNSGKMNAIVEAESSKNELW------DSMMVSRMKTQ--------EQSI 503

  Fly   393 EKLQLALAARERAEKKQQEYEDRLKQMQEDMERSQRDLLEAQDMIRRLEEQLKQLQAAKDELELR 457
            |..:|    .::.:..:::||::|.:|::..   :.|:.:.|:.:   ||..::||..|:.|...
pombe   504 ELTRL----YKQLQDIEEDYENKLMRMEQQW---REDVDQLQEYV---EEITQELQDTKEVLSKS 558

  Fly   458 QKELQAMLQ-----RLEEAKNMEAVEKL--KLEEEIMAKQMEVQRIQDEV-------NAK----D 504
            .||.....:     |.|..:.:|..||.  :.||.|...:.||:::.||:       |.|    |
pombe   559 SKESDDYEEVVGKLRTEAEREIEKFEKTIRENEESISLFKEEVEKLTDEITQLSERYNDKCHEFD 623

  Fly   505 EETKRLQD-EVEDARRKQVIAAEAAAALLAASTTPQHHHVAEDENENEEELTNGDAGGDVSRDLD 568
            |..||||. |.|:.:.|:...::.:..|.....|.........|||..:::.          .|.
pombe   624 ELQKRLQTLEEENNKAKEDSTSKTSNLLEQLKMTEAEVDSLRKENEENKQVI----------ALK 678

  Fly   569 TDEHIKDPIEDRRTLAERNERLHDQLKAL----------KQDLAQSRDETKETANDKIH------ 617
            ..|.:|.. :::..|.|:.|.|:|||..|          |:.||......||..||::.
pombe   679 ESELVKSN-DNKLLLNEQIESLNDQLSQLKTEMESVTTSKESLADYLSNLKERHNDELDSLNKKL 742

  Fly   618 -------------RENVRQGRDKYKTLRE 633
                         :..:.:..::|.||||
pombe   743 REFEGILSSNSSLKSEIEERNNQYVTLRE 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604	41/259 (16%)
		FERM_N	28..83	CDD:286467	4/16 (25%)
		FERM_M	163..278	CDD:278785	23/148 (16%)
		FERM_C_ERM	272..368	CDD:270015	16/110 (15%)
		GBP_C	<375..497	CDD:303769	30/128 (23%)
		ERM	403..649	CDD:279153	65/279 (23%)
		coiled coil	464..477	CDD:293879	3/17 (18%)
		coiled coil	486..497	CDD:293879	3/10 (30%)
mto1	NP_588284.1	Cnn_1N	252..319	CDD:285263	10/77 (13%)
		Fib_alpha	511..611	CDD:285864	26/105 (25%)
		Mto2_bdg	1052..1101	CDD:289572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000