DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Moe and Frmd4b

DIOPT Version :9

Sequence 1:	NP_727290.1	Gene:	Moe / 31816	FlyBaseID:	FBgn0011661	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001333566.1	Gene:	Frmd4b / 232288	MGIID:	2141794	Length:	1035	Species:	Mus musculus

Alignment Length:	700	Identity:	146/700 - (20%)
Similarity:	268/700 - (38%)	Gaps:	201/700 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIKLYKKPESPAIKTIKYLK 96
            |..||..:|.....::|.|.|.....|:|..:||:.:.|..|...|::|
Mouse    68 DRRLELLVQPKLLSRELLDLVASHFNLKEKEYFGITFIDDTGQENWLQL---------------- 116

  Fly    97 RVKKYVDKKTADSNGVNHLETSEEDDDADDMTGSMPFSTWVMNQDVKKENPLQFRFRAKFYPEDV 161
                       |...:.|               .:|          ||..|....|..:||.|.:
Mouse   117 -----------DHRVLEH---------------DLP----------KKPGPTLLHFAVRFYIESI 145

  Fly   162 AEELIQD-ITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDHNKTTHTAGFLANDRLL 225
            :  .::| .|:.||:|..|..:...:|....||...||:..:|...||:....:....|....:.
Mouse   146 S--FLKDKNTVELFFLNAKACVHKGQIEVDSETIFKLAALVLQESKGDYTSDENARKDLKTLPVF 208

  Fly   226 PQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYGVNYFEIRNKKGTDLWL 290
            |.:.:.:|. |....|..::..:.:.:.:.|..|:::|:||.:.|..|||:|:.:::|:|...||
Mouse   209 PTKTLQEHP-SLAYCEDRVIEHYLKIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWL 272

  Fly   291 GVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDFMFFAPRVRINKR---- 351
            |:...|:..|:..|::.|:..|.|.::.|:.|.||||.::..|.:         |:.:::|
Mouse   273 GISYKGIGQYDLQDKVKPRKLFQWKQLENLYFREKKFAVEVHDPR---------RISVSRRTFGQ 328

  Fly   352 -----------------ILALCMGNHELYMRR----------RKPDTIDVQ-------------- 375
                             |..:.:..|:.|:.|          |..|.|.:.
Mouse   329 SGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQSKAKIPSARSLDDIAMDLTETGTQRGSKLVT 393

  Fly   376 -QMKAQ-------------AREEKNAKQQEREKLQLALAARER--AEKKQQEYEDRLKQMQEDME 424
             :.|:|             :::.:..::|:|||: |.|..:|:  .||..|:.|:..|....:.|
Mouse   394 LEAKSQFIMASNGSLISSGSQDSEGMEEQKREKI-LELKKKEKLLQEKLLQKVEELKKICLREAE 457

  Fly   425 RSQR-------DLLEAQDMIRR-------LEEQLKQLQAAKDELELRQKELQAMLQRLEEAKNME 475
            .:.|       ::.|....:||       |::   .|...:::..|::.|...::|:    |.:|
Mouse   458 LTGRMPKEYPLNIGEKPPQVRRRVGTTFKLDD---NLLPTEEDPALQELESNFLIQQ----KLVE 515

  Fly   476 AVEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVEDARRKQVIAAEAAAALLAASTTPQH 540
            |.:||..|.: :.|.::.:|.||..:|    .|||| |:|::..:..|......:..||...|:
Mouse   516 AAKKLASEPD-LCKTVKKKRKQDYTDA----VKRLQ-EIENSINEYRIRCGKKPSQKAAVVPPE- 573

  Fly   541 HHVAEDENENEEELTNGDAGGDVSRDLDTDEHIKDPIEDRRTLAERN------------------ 587
             .:...|:.:..:.|..|                || .|..|||.:.
Mouse   574 -DIIPSESSSLSDTTTYD----------------DP-NDSFTLAGQRPSSVPHSPRILPPKSLGI 620

  Fly   588 ERLHDQLKALKQDLAQSRDETKETANDKIHRENVRQGRDKYKTLREIRKG 637
            ||:|.:..::.:....:|..          ||.:......||||....:|
Mouse   621 ERIHFRKSSINEQFMDTRHS----------REMLSTHSSPYKTLERRPQG 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604	53/246 (22%)
		FERM_N	28..83	CDD:286467	15/50 (30%)
		FERM_M	163..278	CDD:278785	28/115 (24%)
		FERM_C_ERM	272..368	CDD:270015	28/126 (22%)
		GBP_C	<375..497	CDD:303769	32/165 (19%)
		ERM	403..649	CDD:279153	56/268 (21%)
		coiled coil	464..477	CDD:293879	3/12 (25%)
		coiled coil	486..497	CDD:293879	2/10 (20%)
Frmd4b	NP_001333566.1	Necessary for adherens junction and tight junction localization. /evidence=ECO:0000269\|PubMed:20080746	542..972		29/148 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..615		12/70 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..699		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..738
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..798
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..926
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..958
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	994..1035
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810