Protein Alignment Moe and Frmd4b

DIOPT Version :10

• Sequence 1: NP_727290.1
• Gene: Moe / 31816
• FlyBaseID: FBgn0011661
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001333566.1
• Gene: Frmd4b / 232288
• MGIID: 2141794
• Length: 1035
• Species: Mus musculus
• Alignment Length: 700
• Identity: 146/700 - (20%)
• Similarity: 268/700 - (38%)
• Gaps: 201/700 - (28%)

  Fly    32 DAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIKLYKKPESPAIKTIKYLK 96
            |..||..:|.....::|.|.|.....|:|..:||:.:.|..|...|::|
Mouse    68 DRRLELLVQPKLLSRELLDLVASHFNLKEKEYFGITFIDDTGQENWLQL---------------- 116

  Fly    97 RVKKYVDKKTADSNGVNHLETSEEDDDADDMTGSMPFSTWVMNQDVKKENPLQFRFRAKFYPEDV 161
                       |...:.|               .:|          ||..|....|..:||.|.:
Mouse   117 -----------DHRVLEH---------------DLP----------KKPGPTLLHFAVRFYIESI 145

  Fly   162 AEELIQD-ITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDHNKTTHTAGFLANDRLL 225
            :  .::| .|:.||:|..|..:...:|....||...||:..:|...||:....:....|....:.
Mouse   146 S--FLKDKNTVELFFLNAKACVHKGQIEVDSETIFKLAALVLQESKGDYTSDENARKDLKTLPVF 208

  Fly   226 PQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYGVNYFEIRNKKGTDLWL 290
            |.:.:.:|. |....|..::..:.:.:.:.|..|:::|:||.:.|..|||:|:.:::|:|...||
Mouse   209 PTKTLQEHP-SLAYCEDRVIEHYLKIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWL 272

  Fly   291 GVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDFMFFAPRVRINKR---- 351
            |:...|:..|:..|::.|:..|.|.::.|:.|.||||.::..|.:         |:.:::|
Mouse   273 GISYKGIGQYDLQDKVKPRKLFQWKQLENLYFREKKFAVEVHDPR---------RISVSRRTFGQ 328

  Fly   352 -----------------ILALCMGNHELYMRR----------RKPDTIDVQ-------------- 375
                             |..:.:..|:.|:.|          |..|.|.:.
Mouse   329 SGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQSKAKIPSARSLDDIAMDLTETGTQRGSKLVT 393

  Fly   376 -QMKAQ-------------AREEKNAKQQEREKLQLALAARER--AEKKQQEYEDRLKQMQEDME 424
             :.|:|             :::.:..::|:|||: |.|..:|:  .||..|:.|:..|....:.|
Mouse   394 LEAKSQFIMASNGSLISSGSQDSEGMEEQKREKI-LELKKKEKLLQEKLLQKVEELKKICLREAE 457

  Fly   425 RSQR-------DLLEAQDMIRR-------LEEQLKQLQAAKDELELRQKELQAMLQRLEEAKNME 475
            .:.|       ::.|....:||       |::   .|...:::..|::.|...::|:    |.:|
Mouse   458 LTGRMPKEYPLNIGEKPPQVRRRVGTTFKLDD---NLLPTEEDPALQELESNFLIQQ----KLVE 515

  Fly   476 AVEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVEDARRKQVIAAEAAAALLAASTTPQH 540
            |.:||..|.: :.|.::.:|.||..:|    .|||| |:|::..:..|......:..||...|:
Mouse   516 AAKKLASEPD-LCKTVKKKRKQDYTDA----VKRLQ-EIENSINEYRIRCGKKPSQKAAVVPPE- 573

  Fly   541 HHVAEDENENEEELTNGDAGGDVSRDLDTDEHIKDPIEDRRTLAERN------------------ 587
             .:...|:.:..:.|..|                || .|..|||.:.
Mouse   574 -DIIPSESSSLSDTTTYD----------------DP-NDSFTLAGQRPSSVPHSPRILPPKSLGI 620

  Fly   588 ERLHDQLKALKQDLAQSRDETKETANDKIHRENVRQGRDKYKTLREIRKG 637
            ||:|.:..::.:....:|..          ||.:......||||....:|
Mouse   621 ERIHFRKSSINEQFMDTRHS----------REMLSTHSSPYKTLERRPQG 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604	53/246 (22%)
		FERM_C_ERM	272..368	CDD:270015	28/126 (22%)
		ERM_helical	402..521	CDD:466641	33/134 (25%)
		ERM_C	573..649	CDD:459932	16/82 (20%)
Frmd4b	NP_001333566.1	FERM_F1_FRMD4B	57..145	CDD:340720	25/128 (20%)
		B41	75..260	CDD:214604	50/239 (21%)
		FERM_C_FRMD4A_FRMD4B	256..366	CDD:270012	27/118 (23%)
		CUPID	395..529	CDD:463360	30/142 (21%)
		Necessary for adherens junction and tight junction localization. /evidence=ECO:0000269|PubMed:20080746	542..972		29/148 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	563..615		12/70 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	631..699		7/39 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	713..738
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..798
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	906..926
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	939..958
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	994..1035