DRSC/TRiP Functional Genomics Resources

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Protein Alignment Moe and FRMD4B

DIOPT Version :9

Sequence 1:NP_727290.1 Gene:Moe / 31816 FlyBaseID:FBgn0011661 Length:649 Species:Drosophila melanogaster
Sequence 2:XP_016861478.1 Gene:FRMD4B / 23150 HGNCID:24886 Length:1063 Species:Homo sapiens


Alignment Length:690 Identity:142/690 - (20%)
Similarity:262/690 - (37%) Gaps:182/690 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 DAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIKLYKKPESPAIKTIKYLK 96
            |..||..:|.....::|.|.|.....|:|..:||:.:.|..|...|::|                
Human    68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQL---------------- 116

  Fly    97 RVKKYVDKKTADSNGVNHLETSEEDDDADDMTGSMPFSTWVMNQDVKKENPLQFRFRAKFYPEDV 161
                       |...::|               .:|          ||..|....|..:||.|.:
Human   117 -----------DHRVLDH---------------DLP----------KKPGPTILHFAVRFYIESI 145

  Fly   162 AEELIQD-ITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDHNKTTHTAGFLANDRLL 225
            :  .::| .|:.||:|..|..:...:|....||...||::.:|...||:....:....|......
Human   146 S--FLKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFILQEAKGDYTSDENARKDLKTLPAF 208

  Fly   226 PQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYGVNYFEIRNKKGTDLWL 290
            |.:.:.:|. |....|..::..:.:.:.:.|..|:::|:||.:.|..|||:|:.:::|:|...||
Human   209 PTKTLQEHP-SLAYCEDRVIEHYLKIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWL 272

  Fly   291 GVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDFMFFAPRVRINKR---- 351
            |:...|:..|:..|::.|:..|.|.::.|:.|.||||.::..|.:         |:.:::|    
Human   273 GISYKGIGQYDIQDKVKPRKLFQWKQLENLYFREKKFAVEVHDPR---------RISVSRRTFGQ 328

  Fly   352 -----------------ILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQEREKLQLAL 399
                             |..:.:..|:.|:.|:        |.||:.   .:|:..:...:.|..
Human   329 SGLFVQTWYANSSLIKSIWVMAISQHQFYLDRK--------QSKAKI---PSARSLDEIAMDLTE 382

  Fly   400 AARERAEK---------------------KQQEYEDRLKQMQED-MERSQRDLLEAQDMIRRLEE 442
            ...:||.|                     ..|:.|...:|.:|. :|..:::.|..:.:::::||
Human   383 TGTQRASKLVTLETKSQFIMASNGSLISSGSQDSEVSEEQKREKILELKKKEKLLQEKLLKKVEE 447

  Fly   443 QLKQLQAAKDEL-----------------ELRQK--------------ELQAMLQRLE-----EA 471
             ||::...:.||                 ::|::              |....||.||     :.
Human   448 -LKKICLREAELTGKMPKEYPLNIGEKPPQVRRRVGTAFKLDDNLLPSEEDPALQELESNFLIQQ 511

  Fly   472 KNMEAVEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVEDARRKQVIAA----EAAAALL 532
            |.:||.:||..|.: :.|.::.:|.||..:|    .|:|| |:|:|..:..|..    ...|.:|
Human   512 KLVEAAKKLANEPD-LCKTVKKKRKQDYTDA----MKKLQ-EIENAINEYRIRCGKKPSQKATVL 570

  Fly   533 AASTTPQHHHVAEDENENEEELTNGDAGGDVSRDLDTDEHIKDPIEDRRTLAERNERLHDQLKAL 597
            .....|.......|....::........|..|..:.....|..|    ::|.  .||:|.:..::
Human   571 PEDIIPSESSSLSDTTTYDDPSDAFTFPGQRSSSVPHSPRILPP----KSLG--IERIHFRKSSI 629

  Fly   598 KQDLAQSRDETKETANDKIHRENVRQGRDKYKTLREIRKG 637
            .:....:|..          ||.:......||||....:|
Human   630 NEQFVDTRQS----------REMLSTHSSPYKTLERRPQG 659

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MoeNP_727290.1 B41 26..278 CDD:214604 53/246 (22%)
FERM_N 28..83 CDD:286467 15/50 (30%)
FERM_M 163..278 CDD:278785 28/115 (24%)
FERM_C_ERM 272..368 CDD:270015 28/116 (24%)
GBP_C <375..497 CDD:303769 34/179 (19%)
ERM 403..649 CDD:279153 59/297 (20%)
coiled coil 464..477 CDD:293879 6/17 (35%)
coiled coil 486..497 CDD:293879 2/10 (20%)
FRMD4BXP_016861478.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3529
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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