DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Moe and Nf2

DIOPT Version :9

Sequence 1:	NP_727290.1	Gene:	Moe / 31816	FlyBaseID:	FBgn0011661	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_035028.2	Gene:	Nf2 / 18016	MGIID:	97307	Length:	596	Species:	Mus musculus

Alignment Length:	652	Identity:	271/652 - (41%)
Similarity:	384/652 - (58%)	Gaps:	88/652 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SVKR---KTLNVRVTTMDAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIK 79
            |:||   ||..||:.|||||:||..:....||.|||.|.:|:||||.|||||||| .|....|:|
Mouse    13 SLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLK 76

  Fly    80 LYKKPESPAIKTIKYLKRVKKYVDKKTADSNGVNHLETSEEDDDADDMTGSMPFSTWVMNQDVKK 144
            :.||                                                     |::.||.|
Mouse    77 MDKK-----------------------------------------------------VLDHDVSK 88

  Fly   145 ENPLQFRFRAKFYPEDVAEELIQDITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDH 209
            |.|:.|.|.||||||:..|||:|:||..||:||||..||.:::|||||.|||||||||||::||:
Mouse    89 EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKVYCPPEASVLLASYAVQAKYGDY 153

  Fly   210 NKTTHTAGFLANDRLLPQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYG 274
            :.:.|..||||.:.|||:|||:.::|:.:.||:.|..|:.|||...|::|.||||||||||||||
Mouse   154 DPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYG 218

  Fly   275 VNYFEIRNKKGTDLWLGVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDF 339
            ||||.|||||||:|.||||||||:||:.::||||||.|||:||||||:|:|:|.|||:|||...|
Mouse   219 VNYFTIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVF 283

  Fly   340 MFFAPRVRINKRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQEREKLQLALAARER 404
            .|.:.::|:||.||.||:|||:|:|||||.|:::||||||||||||..||.||::|......||.
Mouse   284 KFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREE 348

  Fly   405 AEKKQQEYEDRLKQMQEDMERSQRDLLEAQDMIRRL-------EEQLKQLQAAKDELELRQKELQ 462
            ||:.:.|.|.||.||:|:...:...|:.:::....|       ||:.|.|.....|.|...:.::
Mouse   349 AERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIK 413

  Fly   463 AMLQRLEEAKNMEAVEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVEDARRKQVIAAEA 527
            |...|.||.|.:  :|:..||.|::|.:|     .:|...:.:|..:|:.::::||..:   ..|
Mouse   414 ATAIRTEEEKRL--MEQKVLEAEVLALKM-----AEESERRAKEADQLKQDLQEAREAE---RRA 468

  Fly   528 AAALLAASTTPQHHHVAEDENENEEELTNGDAGGD-VSRDL-DTD------EHIKDPIEDRRTLA 584
            ...||..:|.|.:..:.........::.:.|...| :|.|. |||      |..|:.:|    ..
Mouse   469 KQKLLEIATKPTYPPMNPIPPPLPPDIPSFDIIADSLSFDFKDTDMKRLSMEIEKEKVE----YM 529

  Fly   585 ERNERLHDQLKALKQDLAQSRDETKETANDKIHRENVRQG--RDKYKTLREIRKGNTKRRVDQFE 647
            |:::.|.:||..||.::...:.:.:|||.|.:|.|:..:|  ..|:.|::::...:.|.||..||
Mouse   530 EKSKHLQEQLNELKTEIEALKLKERETALDVLHSESSDRGGPSSKHNTIKKLTLQSAKSRVAFFE 594

  Fly   648 NM 649
            .:
Mouse   595 EL 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604	116/251 (46%)
		FERM_N	28..83	CDD:286467	29/54 (54%)
		FERM_M	163..278	CDD:278785	69/114 (61%)
		FERM_C_ERM	272..368	CDD:270015	65/95 (68%)
		GBP_C	<375..497	CDD:303769	46/128 (36%)
		ERM	403..649	CDD:279153	69/262 (26%)
		coiled coil	464..477	CDD:293879	4/12 (33%)
		coiled coil	486..497	CDD:293879	2/10 (20%)
Nf2	NP_035028.2	B41	23..222	CDD:214604	116/252 (46%)
		FERM_N	26..87	CDD:286467	33/114 (29%)
		FERM_M	107..222	CDD:278785	69/114 (61%)
		FERM_C_ERM	216..312	CDD:270015	65/95 (68%)
		ERM	347..596	CDD:279153	69/262 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..580		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281811at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820