DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Moe and nfm-1

DIOPT Version :9

Sequence 1:	NP_727290.1	Gene:	Moe / 31816	FlyBaseID:	FBgn0011661	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_498336.1	Gene:	nfm-1 / 175870	WormBaseID:	WBGene00003593	Length:	709	Species:	Caenorhabditis elegans

Alignment Length:	718	Identity:	234/718 - (32%)
Similarity:	334/718 - (46%)	Gaps:	182/718 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GGVSV---KRKTLNVRVTTMDAELE-FAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDS 75
            ||.|:   ..|.:..:|:||||:|| ..|:.|.||:.||:.|.:.|||||.|:||||:|:.|...
Worm     2 GGFSIFSRNTKPIYAKVSTMDADLEKIVIEKTWTGRHLFEAVCRIIGLRETWYFGLQFTNKKNIP 66

  Fly    76 TWIKLYKKPESPAIKTIKYLKRVKKYVDKKTADSNGVNHLETSEEDDDADDMTGSMPFSTWVMNQ 140
            .|::                                             :|.|        :..|
Worm    67 CWLQ---------------------------------------------NDKT--------ICGQ 78

  Fly   141 DVKK---ENPLQFRFRAKFYPEDVAEELIQDITLRLFYLQVKNAILTDEIYCPPETSVLLASYAV 202
            |::|   :....|.|..|||||||..|:|.|.|..||:||::.|||:..:||.||.||||||:||
Worm    79 DIQKDTSDGTFNFLFLVKFYPEDVEPEIILDATRHLFFLQIREAILSMNLYCSPEASVLLASFAV 143

  Fly   203 QARHGDHNKTTHTAGFLANDRLLPQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIA 267
            ||.|||   .|...|.:..|:.||:.||||:.||.|.|...|..||..:....||:|.:|||::|
Worm   144 QAMHGD---CTEEVGPIDLDKHLPKSVIDQYDMSADMWRDRIKRWWSRNAGQSREEAELEYLRVA 205

  Fly   268 QDLEMYGVNYFEIRNKKGTDLWLGVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPI 332
            |||||||:.|:.|.|.|.|||.||:.|.||.||:..:|:||:..|.||||:||.|..:||.:|.:
Worm   206 QDLEMYGILYYPICNNKETDLHLGISAQGLGIYKGVNRITPRPFFSWSEIKNIQFKNRKFHMKTV 270

  Fly   333 DKKAPDFMFFAPRVRINKRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQEREKLQL 397
            ||..  ..|.:....|:..||.||:|.|.||:|||:|||::||||::||:|:|..:..|:.|:.|
Worm   271 DKST--ISFRSRETSIDSSILDLCIGTHNLYLRRRQPDTLEVQQMRSQAKEDKQRRAAEQAKVAL 333

  Fly   398 ALAARERAEKKQQEYEDRLKQMQEDMERSQRDLLEAQDMIRRLEEQLKQL--QAAKDELE----L 456
                 ||.|::|.|.|  .|:|::.:|....:|::||:.||:.||...||  :|...|.|    .
Worm   334 -----ERKERQQMEKE--YKEMKQKVEVMTLELMKAQENIRKAEEANDQLAEKARHSEHETLMLY 391

  Fly   457 RQK-ELQAMLQRL--EEAKNMEA---VEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVE 515
            :|| |::|...||  ...|:.||   :|:...|.||:||||.:.               |.|...
Worm   392 KQKSEVEAECNRLSMNNMKSEEALLRMERKAREAEILAKQMSMS---------------LADVSL 441

  Fly   516 DARRKQVIAAEAAAAL------------------------------LAASTTPQ----------- 539
            ||.||....:..:|.:                              |...|.||
Worm   442 DANRKMTQYSSQSALIIDPNWHQQVSGHQSGHPGMPSTGSFHQLQSLDTHTHPQQMMSRSLNMPS 506

  Fly   540 ---------------------------HHHVAEDENENEEELTNGDA------GGDVSRDLDTD- 570
                                       |....:.:|:|:.....|..      ...:|:..:..
Worm   507 SAFSSPIPSNQPLSHQQPQQMSQNTQAHQQQTQVQNQNQPPYYGGSGMIIPPPDPSISQIFEQQT 571

  Fly   571 -----EHIKDPIEDR-RTLAERNERLHDQLKALKQDLAQSRDETKETANDKIHRENVRQGRDKYK 629
                 |..:...|.| |...|..|.|...:..||:|......:.:|  :|.:|.:||..|.||:.
Worm   572 TLMELEKSRSEYETRARIFKEHLEELRGDIDGLKRDGNVQNGQHRE--HDAVHAQNVAHGFDKFT 634

  Fly   630 TLR 632
            |:|
Worm   635 TMR 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604	99/255 (39%)
		FERM_N	28..83	CDD:286467	27/55 (49%)
		FERM_M	163..278	CDD:278785	58/114 (51%)
		FERM_C_ERM	272..368	CDD:270015	45/95 (47%)
		GBP_C	<375..497	CDD:303769	48/133 (36%)
		ERM	403..649	CDD:279153	74/323 (23%)
		coiled coil	464..477	CDD:293879	5/17 (29%)
		coiled coil	486..497	CDD:293879	5/10 (50%)
nfm-1	NP_498336.1	B41	16..216	CDD:214604	99/255 (39%)
		FERM_C_ERM	210..304	CDD:270015	45/95 (47%)
		G_path_suppress	320..>526	CDD:374274	53/227 (23%)
		ERM	339..>432	CDD:366293	33/94 (35%)
		Med15	<464..>608	CDD:312941	18/143 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281811at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920