DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Moe and msn

DIOPT Version :9

Sequence 1:	NP_727290.1	Gene:	Moe / 31816	FlyBaseID:	FBgn0011661	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_002936828.1	Gene:	msn / 100145669	XenbaseID:	XB-GENE-1004600	Length:	580	Species:	Xenopus tropicalis

Alignment Length:	657	Identity:	355/657 - (54%)
Similarity:	446/657 - (67%)	Gaps:	108/657 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KTLNVRVTTMDAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIKLYKKPES 86
            ||::|||||||||||||||..||||||||||||||||||||||||||.|:||.|||:||.||
Frog     3 KTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKK--- 64

  Fly    87 PAIKTIKYLKRVKKYVDKKTADSNGVNHLETSEEDDDADDMTGSMPFSTWVMNQDVKKENPLQFR 151
                                                              |..|||:|::||.|:
Frog    65 --------------------------------------------------VTAQDVRKDSPLLFK 79

  Fly   152 FRAKFYPEDVAEELIQDITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDHNKTTHTA 216
            ||||||||||:||||||||.|||:||||..||.|:|||||||:||||||||||::||:||.....
Frog    80 FRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQAKYGDYNKECQKP 144

  Fly   217 GFLANDRLLPQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYGVNYFEIR 281
            |:|:.|:||||||::|||:|||:||:.|..|.:|||.||||||::|||||||||||||||||.|:
Frog   145 GYLSGDKLLPQRVLEQHKLSKDQWEERIHVWHEEHRGMLREDAILEYLKIAQDLEMYGVNYFSIK 209

  Fly   282 NKKGTDLWLGVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDFMFFAPRV 346
            ||||::|||||||||||||||:|||||||||||||||||||::|||:|||||||||||:|:|||:
Frog   210 NKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRL 274

  Fly   347 RINKRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQER-------EKLQLALAARER 404
            ||||||||||||||||||||||||||:||||||||||||:.||.||       :|.:||...:|:
Frog   275 RINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQMERALLENEKKKRELAEKEKEK 339

  Fly   405 AEKKQQEYEDRLKQM-------QEDMERSQRDLLEAQDMIRRLEEQLKQLQAAKDELELRQKELQ 462
            .|::::|..:||:|:       ||.:|...|..||.:|..||.:|:.::|  |::.|...:.:..
Frog   340 IEREKEELMERLRQIEDQTRKAQEALEEQTRKALELEDERRRAQEEAEKL--ARERLAAEEAKEA 402

  Fly   463 AMLQRLEEAKNME--AVEKLKLEEEI-------MAKQMEVQRIQDEVNAKDEETKRLQDEVEDAR 518
            .:.|..::.||.|  |.|...|...|       ..|::|.|..||:.:....:.::.|:|
Frog   403 LLKQSQDQMKNQEHLAAELSALTATISQLEFARQKKELEAQEWQDKAHNVQADLEKTQEE----- 462

  Fly   519 RKQVIAAEAAAALLAASTTPQHHHV-----AEDENENEEELTNGDAGGDVSRDLDTDEHIKD-PI 577
                        |....|||   ||     ||:|:::|:...|.:|    |.:|.::..||| ..
Frog   463 ------------LKLVMTTP---HVPEPVHAENEHDDEDNENNAEA----SAELKSEAMIKDRSE 508

  Fly   578 EDRRTLAERNERLHDQLKALKQDLAQSRDETKETANDKIHRENVRQGRDKYKTLREIRKGNTKRR 642
            |||.|.||:|||:...|..|..:||.:|||||:||||.:|.||||.|||||||||:||:||||:|
Frog   509 EDRTTEAEKNERVQKHLLLLSSELANARDETKKTANDLLHAENVRAGRDKYKTLRQIRQGNTKQR 573

  Fly   643 VDQFENM 649
            :|:||:|
Frog   574 IDEFESM 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604	151/251 (60%)
		FERM_N	28..83	CDD:286467	47/54 (87%)
		FERM_M	163..278	CDD:278785	82/114 (72%)
		FERM_C_ERM	272..368	CDD:270015	84/95 (88%)
		GBP_C	<375..497	CDD:303769	48/144 (33%)
		ERM	403..649	CDD:279153	97/267 (36%)
		coiled coil	464..477	CDD:293879	4/14 (29%)
		coiled coil	486..497	CDD:293879	4/17 (24%)
msn	XP_002936828.1	B41	7..206	CDD:214604	151/251 (60%)
		FERM_C_ERM	200..296	CDD:270015	84/95 (88%)
		ERM	347..580	CDD:366293	94/258 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3201
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1833
Inparanoid	1	1.050	687	1.000	Inparanoid score	I688
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281811at33208
OrthoFinder	1	1.000	-	-		FOG0001629
OrthoInspector	1	1.000	-	-		otm48861
Panther	1	1.100	-	-	O	PTHR23281
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1031
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.160