DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32679 and CRISPLD2

DIOPT Version :9

Sequence 1:	NP_727412.2	Gene:	CG32679 / 318150	FlyBaseID:	FBgn0052679	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_113664.1	Gene:	CRISPLD2 / 83716	HGNCID:	25248	Length:	497	Species:	Homo sapiens

Alignment Length:	205	Identity:	60/205 - (29%)
Similarity:	82/205 - (40%)	Gaps:	44/205 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 ILQLHNERRNLIAGGGVSGFPSAVQMATMSWDTTLAQLAAYNALQCRMAHDECRNTNTYRYAGQN 128
            ||.|||:.|..:.       |.|..|..|:||..|.:.||..|.||...|..   |:.....|||
Human    59 ILMLHNKLRGQVQ-------PQASNMEYMTWDDELEKSAAAWASQCIWEHGP---TSLLVSIGQN 113

  Fly   129 LSILFTRSVDVAVFLRQR-----IAAWFDENRDAT---SGDMEDY--QMRGGPAIGHFTTMVNER 183
            |.         |.:.|.|     :.:|:||.:|.|   ..:...:  :...||...|:|.:|...
Human   114 LG---------AHWGRYRSPGFHVQSWYDEVKDYTYPYPSECNPWCPERCSGPMCTHYTQIVWAT 169

  Fly   184 NNRVGCAI---ARFTDANNV--QATLLACNYAVT-NVVNNPVYRAGTAASECTTG-----RNSNY 237
            .|::|||:   .:.|....|  .|....|||:.. |.:....|:.|...|||...     ||
Human   170 TNKIGCAVNTCRKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCRN--- 231

  Fly   238 PNLCSPNEVY 247
             |||...|.|
Human   232 -NLCYREETY 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32679	NP_727412.2	SCP_euk	63..210	CDD:240180	46/160 (29%)
CRISPLD2	NP_113664.1	SCP_euk	56..201	CDD:240180	46/160 (29%)
		LCCL	286..370	CDD:128866
		LCCL	387..479	CDD:128866
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151210
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1528782at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10334
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2242
SonicParanoid	1	1.000	-	-		X35
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.880