DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab9E and RABL6

DIOPT Version :9

Sequence 1:	NP_727438.1	Gene:	Rab9E / 318148	FlyBaseID:	FBgn0052673	Length:	197	Species:	Drosophila melanogaster
Sequence 2:	NP_001167459.1	Gene:	RABL6 / 55684	HGNCID:	24703	Length:	730	Species:	Homo sapiens

Alignment Length:	157	Identity:	39/157 - (24%)
Similarity:	64/157 - (40%)	Gaps:	38/157 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QYDNPFKIIILGDSGVGKTCLLMRFSDNQFTTRHRSTLGMDRRECSVEFADWRMGR-----MLQV 62
            ||:  .||:|.||...|||.|..|.....|...:..|     :|..|....|....     .::|
Human    41 QYN--MKIVIRGDRNTGKTALWHRLQGRPFVEEYIPT-----QEIQVTSIHWSYKTTDDIVKVEV 98

  Fly    63 WDTSDDERFKL----LKATH------------------CRSAHGILLVYDITSSKSFQNIDGWMK 105
            ||..|..:.|.    ||..:                  .::.:|:::::|||...:|..|   ::
Human    99 WDVVDKGKCKKRGDGLKMENDPQEAESEMALDAEFLDVYKNCNGVVMMFDITKQWTFNYI---LR 160

  Fly   106 EIRRLCPDKVIVLLVGNKSDDPNHRQV 132
            |:.:: |..|.|.::||..|...||.:
Human   161 ELPKV-PTHVPVCVLGNYRDMGEHRVI 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab9E	NP_727438.1	RAB	8..171	CDD:197555	37/152 (24%)
Rab9E	NP_727438.1	Rab	8..167	CDD:206640	37/152 (24%)
RABL6	NP_001167459.1	P-loop_NTPase	44..222	CDD:304359	37/152 (24%)
		Ras	45..222	CDD:278499	37/151 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..730
		Interaction with CDKN2A. /evidence=ECO:0000269\|PubMed:16582619	656..694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900