DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32668 and PKP4

DIOPT Version :9

Sequence 1:	NP_727502.1	Gene:	CG32668 / 318147	FlyBaseID:	FBgn0052668	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_001364147.1	Gene:	PKP4 / 8502	HGNCID:	9026	Length:	1192	Species:	Homo sapiens

Alignment Length:	747	Identity:	149/747 - (19%)
Similarity:	232/747 - (31%)	Gaps:	294/747 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SRSETRPQANP-AEMAKQPADS-------DKSDRQQQ-----LAKHHQMRHH--------QPHAS 52
            |||.|  |.|. ::...|.|.|       .|:|.:||     ...:|.:|:.        ||..:
Human   143 SRSST--QMNSYSDSGYQEAGSFHNSQNVSKADNRQQHSFIGSTNNHVVRNSRAEGQTLVQPSVA 205

  Fly    53 EQSLNKLGLVSSGTSGMGRRKTSAELISEAKMFLGESVNAVPL---LATG-GARLVSTRRPITPR 113
            .:::.::..|.|      |.::.:.:||     .|.|.:...|   |.:| |:..|:..||:.|.
Human   206 NRAMRRVSSVPS------RAQSPSYVIS-----TGVSPSRGSLRTSLGSGFGSPSVTDPRPLNPS 259

  Fly   114 ESGRVLYGKVAL-AGRPPSAFSMRYLQNEKPSTPRQLPALSGSVSATPMPTRNGALLCQSSTETL 177
                 .|....| |.|..|.:|.|      |::|..:..: |||::......||.
Human   260 -----AYSSTTLPAARAASPYSQR------PASPTAIRRI-GSVTSRQTSNPNGP---------- 302

  Fly   178 IELLKQHSGLKDCSDETVQHINA--ILQELYTRVRKQERNYKRGFILGGLYGLVECTSPRVLLAV 240
               ..|:        :|...:.:  .|.:..|||....:            |.|..:||:
Human   303 ---TPQY--------QTTARVGSPLTLTDAQTRVASPSQ------------GQVGSSSPK----- 339

  Fly   241 ARVVLALRVTGSNLTGACKLIFKVARHEQHD-ALF--HEHDVLELLIDGLGHASPLDEPEACIYA 302
                      .|.:|...:.:....:...|| ..|  .::|:.|.::
Human   340 ----------RSGMTAVPQHLGPSLQRTVHDMEQFGQQQYDIYERMV------------------ 376

  Fly   303 YGCIRFLTASSAQERDDALNRNWIGLETSGESQSLPIPALMPPALSAISTSLCPRKLTGQQTLVS 367
                        ..|.|:|.    ||.:|..||.   ..|.....||:|..|....:...:|..|
Human   377 ------------PPRPDSLT----GLRSSYASQH---SQLGQDLRSAVSPDLHITPIYEGRTYYS 422

  Fly   368 ---RLARHGAVELMILHLQMLNEAGATKRLQGPPLHTLYQLSAAMRALADVSQQQQRLQLQLQLA 429
               |...||.||                 |||.                             |.|
Human   423 PVYRSPNHGTVE-----------------LQGS-----------------------------QTA 441

  Fly   430 CPHLIRAAEVSMGELEVQANVVRTLSVLSEDSDCCETLHNYAARIGLLLGPSCAGGGQWSERLLA 494
               |.|...|.:|.|:      ||.                                  |:|...
Human   442 ---LYRTGSVGIGNLQ------RTS----------------------------------SQRSTL 463

  Fly   495 VLSRLGYMLGNILAKHESAR-IQYFHNDVAMEYLLNVLEQLNERSPSSVAHLDAQIKLIRVVANM 558
            ...|..|.|.......|..| |||               ::.|.:.:.:.|
Human   464 TYQRNNYALNTTATYAEPYRPIQY---------------RVQECNYNRLQH-------------- 499

  Fly   559 SVNPEVGAGLGNVRSLGAVLLQLLSKTSEELTKKKSPEQQELLH----------ATLGA-LHNLC 612
                .|.|..|..||..   :..:.|...|.. .:.||..|::|          |...| |.:||
Human   500 ----AVPADDGTTRSPS---IDSIQKDPREFA-WRDPELPEVIHMLQHQFPSVQANAAAYLQHLC 556

  Fly   613 FYQDKQAAVQPLAEGSLQSLIDDLSASLAKVLGNCQTSVTKVELARVLGNLT-RNEQARRCFCAA 676
            | .|.:..::....|.::.|:|.|...:.:|..|...::..:    |.|..| .|:.|.:   ..
Human   557 F-GDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNL----VFGKSTDENKIAMK---NV 613

  Fly   677 GGLPLMVQQLTKQAAGQDYELRTCAIGVLVNL 708
            ||:|.:::.|.|..   |.|:|....|||.||
Human   614 GGIPALLRLLRKSI---DAEVRELVTGVLWNL 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32668	NP_727502.1	armadillo repeat	571..611	CDD:293788	11/50 (22%)
		armadillo repeat	619..665	CDD:293788	9/46 (20%)
		armadillo repeat	670..708	CDD:293788	11/37 (30%)
PKP4	NP_001364147.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..262		32/136 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..310		6/40 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..348		9/51 (18%)
		ARM 1	415..455		17/94 (18%)
		ARM 2	518..557		10/39 (26%)
		ARM 3	560..599		6/42 (14%)
		ARM 4	604..644		15/45 (33%)
		ARM 5	660..702
		ARM 6	706..751
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	773..810
		ARM 7	815..855
		ARM 8	862..901
		ARM 9	950..993
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1058..1086
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900