Protein Alignment CG32668 and PKP4

DIOPT Version :10

• Sequence 1: NP_727502.1
• Gene: CG32668 / 318147
• FlyBaseID: FBgn0052668
• Length: 863
• Species: Drosophila melanogaster
• Sequence 2: NP_003619.2
• Gene: PKP4 / 8502
• HGNCID: 9026
• Length: 1192
• Species: Homo sapiens
• Alignment Length: 754
• Identity: 147/754 - (19%)
• Similarity: 227/754 - (30%)
• Gaps: 308/754 - (40%)

  Fly     9 SRSETRPQANP-AEMAKQPADS-------DKSDRQQQ-----LAKHHQMRHH--------QPHAS 52
            |||.|  |.|. ::...|.|.|       .|:|.:||     ...:|.:|:.        ||..:
Human   143 SRSST--QMNSYSDSGYQEAGSFHNSQNVSKADNRQQHSFIGSTNNHVVRNSRAEGQTLVQPSVA 205

  Fly    53 EQSLNKLG-----------LVSSGTS-GMGRRKTSAELISEAKMFLGESVNAVPLLATG-GARLV 104
            .:::.::.           ::|:|.| ..|..:||                    |.:| |:..|
Human   206 NRAMRRVSSVPSRAQSPSYVISTGVSPSRGSLRTS--------------------LGSGFGSPSV 250

  Fly   105 STRRPITPRESGRVLYGKVAL-AGRPPSAFSMRYLQNEKPSTPRQLPALSGSVSATPMPTRNGAL 168
            :..||:.|.     .|....| |.|..|.:|.|      |::|..:..: |||::......||..
Human   251 TDPRPLNPS-----AYSSTTLPAARAASPYSQR------PASPTAIRRI-GSVTSRQTSNPNGPT 303

  Fly   169 LCQSSTETLIELLKQHSGLKDCSDETVQHINAILQELYTRVRKQERNYKRGFILGGLYGLVECTS 233
            ....:|..:...|                   .|.:..|||....:            |.|..:|
Human   304 PQYQTTARVGSPL-------------------TLTDAQTRVASPSQ------------GQVGSSS 337

  Fly   234 PRVLLAVARVVLALRVTGSNLTGACKLIFKVARHEQHD-ALF--HEHDVLELLIDGLGHASPLDE 295
            |:               .|.:|...:.:....:...|| ..|  .::|:.|.::
Human   338 PK---------------RSGMTAVPQHLGPSLQRTVHDMEQFGQQQYDIYERMV----------- 376

  Fly   296 PEACIYAYGCIRFLTASSAQERDDALNRNWIGLETSGESQSLPIPALMPPALSAISTSLCPRKLT 360
                               ..|.|:|.    ||.:|..||.   ..|.....||:|..|....:.
Human   377 -------------------PPRPDSLT----GLRSSYASQH---SQLGQDLRSAVSPDLHITPIY 415

  Fly   361 GQQTLVS---RLARHGAVELMILHLQMLNEAGATKRLQGPPLHTLYQLSAAMRALADVSQQQQRL 422
            ..:|..|   |...||.||                 |||.
Human   416 EGRTYYSPVYRSPNHGTVE-----------------LQGS------------------------- 438

  Fly   423 QLQLQLACPHLIRAAEVSMGELEVQANVVRTLSVLSEDSDCCETLHNYAARIGLLLGPSCAGGGQ 487
                |.|   |.|...|.:|.|:      ||.
Human   439 ----QTA---LYRTGSVGIGNLQ------RTS--------------------------------- 457

  Fly   488 WSERLLAVLSRLGYMLGNILAKHESAR-IQYFHNDVAMEYLLNVLEQLNERSPSSVAHLDAQIKL 551
             |:|......|..|.|.......|..| |||               ::.|.:.:.:.|
Human   458 -SQRSTLTYQRNNYALNTTATYAEPYRPIQY---------------RVQECNYNRLQH------- 499

  Fly   552 IRVVANMSVNPEVGAGLGNVRSLGAVLLQLLSKTSEELTKKKSPEQQELLH----------ATLG 606
                       .|.|..|..||..   :..:.|...|.. .:.||..|::|          |...
Human   500 -----------AVPADDGTTRSPS---IDSIQKDPREFA-WRDPELPEVIHMLQHQFPSVQANAA 549

  Fly   607 A-LHNLCFYQDKQAAVQPLAEGSLQSLIDDLSASLAKVLGNCQTSVTKVELARVLGNLT-RNEQA 669
            | |.:||| .|.:..::....|.::.|:|.|...:.:|..|...::..:    |.|..| .|:.|
Human   550 AYLQHLCF-GDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNL----VFGKSTDENKIA 609

  Fly   670 RRCFCAAGGLPLMVQQLTKQAAGQDYELRTCAIGVLVNL 708
            .:   ..||:|.:::.|.|..   |.|:|....|||.||
Human   610 MK---NVGGIPALLRLLRKSI---DAEVRELVTGVLWNL 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32668	NP_727502.1	armadillo repeat	571..611	CDD:293788	11/50 (22%)
		armadillo repeat	619..665	CDD:293788	9/46 (20%)
		armadillo repeat	670..708	CDD:293788	11/37 (30%)
PKP4	NP_003619.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..262		30/145 (21%)
		PHA03247	<194..347	CDD:223021	41/230 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..310		4/19 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..348		9/51 (18%)
		ARM 1	415..455		17/94 (18%)
		ARM 2	518..557		10/39 (26%)
		armadillo repeat	530..555	CDD:293788	5/24 (21%)
		Arm	559..598	CDD:425727	7/42 (17%)
		ARM 3	560..599		6/42 (14%)
		armadillo repeat	563..599	CDD:293788	6/39 (15%)
		ARM	603..644	CDD:214547	16/46 (35%)
		ARM 4	604..644		15/45 (33%)
		armadillo repeat	607..642	CDD:293788	12/40 (30%)
		armadillo repeat	649..700	CDD:293788
		ARM 5	660..702
		ARM 6	706..751
		armadillo repeat	708..749	CDD:293788
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	773..810
		ARM 7	815..855
		armadillo repeat	825..855	CDD:293788
		PLN03200	848..>969	CDD:215629
		ARM 8	862..901
		ARM	865..900	CDD:214547
		armadillo repeat	867..899	CDD:293788
		armadillo repeat	906..947	CDD:293788
		ARM	949..993	CDD:214547
		ARM 9	950..993
		armadillo repeat	953..988	CDD:293788
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1058..1086