DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32668 and ARMC2

DIOPT Version :9

Sequence 1:	NP_727502.1	Gene:	CG32668 / 318147	FlyBaseID:	FBgn0052668	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_115507.4	Gene:	ARMC2 / 84071	HGNCID:	23045	Length:	867	Species:	Homo sapiens

Alignment Length:	987	Identity:	234/987 - (23%)
Similarity:	360/987 - (36%)	Gaps:	342/987 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 HQPHASEQSLNKLGLVSSGTSGMGRRKTSAELISEAKMFLGESVNAVPLLATGGARLVSTRRPIT 111
            :||..|:|                  |||||:||||:       ||:        |.|.|:||.|
Human    16 YQPSVSKQ------------------KTSAEIISEAR-------NAL--------RTVRTQRPFT 47

  Fly   112 PRESGRVLYGKVA---LAGRPPSAFSMRYLQNE----KPSTPRQLPALSGSVSATPMPTR----- 164
            |:|:.|.|:|..:   ...||||:||:.....|    :|.:..:|..|.........|||
Human    48 PQEAQRKLFGPASSRTSENRPPSSFSLHASSFESSDSRPISGTRLSPLELKPKVPASPTREEDSC 112

  Fly   165 --------------------------------------------------------------NGA 167
                                                                          ||.
Human   113 FSFPKPPVDPAKIRRVSNARARLFRAASQRALLPDRSLPPSDSKKTVESKETVMMGDSMVKINGI 177

  Fly   168 LLCQSSTETLIELLKQH--------------------------SGLKDCSDETVQHINA------ 200
            .|.:|:.   |..||.|                          |.||:..|:..:|..|
Human   178 YLTKSNA---ICHLKSHPLQLTDDGGFSEIKEQEMFKGTTSLPSHLKNGGDQGKRHARASSCPSS 239

  Fly   201 ------------------------------------ILQELYTRVRKQERNYK------------ 217
                                                ||:||     ::|.|.:
Human   240 SDLSRLQTKAVPKADLQEEDAEIEVDEVFWNTRIVPILREL-----EKEENIETVCAACTQLHHA 299

  Fly   218 -------------RGFILGGLYGLVECTSPRVLLAVARVVLALRVTGSNLTGACKLIFKVARHEQ 269
                         |..:|..|..||:..|..:.|.:|:::|||:|:..||...||||||::|:|:
Human   300 LEEGNMLGNKFKGRSILLKTLCKLVDVGSDSLSLKLAKIILALKVSRKNLLNVCKLIFKISRNEK 364

  Fly   270 HDALFHEHDVLELLIDGLGHASPLDEPEACIYAYGCIRFLTASSAQERDDALNRNWIGLETSGES 334
            :|:|.....:||.|::.|.........||.:|..|.|:|
Human   365 NDSLIQNDSILESLLEVLRSEDLQTNMEAFLYCMGSIKF-------------------------- 403

  Fly   335 QSLPIPALMPPALSAISTSLCPRKLTGQQTLVSRLARHGAVELMILHLQMLNE----AGATKRLQ 395
                                    ::|....::.:...||||::|..::.:||    .|......
Human   404 ------------------------ISGNLGFLNEMISKGAVEILINLIKQINENIKKCGTFLPNS 444

  Fly   396 GPPLHTLYQLSAAMRALADVSQQQQRLQLQLQLACPHLIRAAEVSMGELEVQANVVRTLSVLSED 460
            |   |.|.|::|.:|.|.|.|..:.:. |.:. |.|.|..|.|...|:.:|..|:.|..|.|:..
Human   445 G---HLLVQVTATLRNLVDSSLVRSKF-LNIS-ALPQLCTAMEQYKGDKDVCTNIARIFSKLTSY 504

  Fly   461 SDCCETLHNYAARIGLLLGPSCAGGGQWSERLLAVLSRLGYMLGNILAKHESARIQYFHNDVAME 525
            .|||..|.:|:....|.|  :.....|..:.|:.   |:.::|||:.||:..||.|:.....:::
Human   505 RDCCTALASYSRCYALFL--NLINKYQKKQDLVV---RVVFILGNLTAKNNQAREQFSKEKGSIQ 564

  Fly   526 YLLNVL------------------EQLNERSPSSVAHLDAQIKLIRVVANMSVNPEVGAGLGNVR 572
            .||::.                  ||...:.|.|.|. |..|||.||:||::::|    |:|.|.
Human   565 TLLSLFQTFHQLDLHSQKPVGQRGEQHRAQRPPSEAE-DVLIKLTRVLANIAIHP----GVGPVL 624

  Fly   573 SLGAVLLQLLSKTSEELTKKKSPEQQELLHATLGALHNLCFYQDKQAAVQP----LAEGSLQSLI 633
            :....::.||..|   |..|...:.:||:......::||.:||.|.:.:|.    :||..|:.|:
Human   625 AANPGIVGLLLTT---LEYKSLDDCEELVINATATINNLSYYQVKNSIIQDKKLYIAELLLKLLV 686

  Fly   634 DDLSASLAKVLGNCQTSVTKVELARVLGNLTRNEQARRC-FCAAGGLPLMVQQLTKQAAGQDYEL 697
               |.::..:|          |..||.|||:::...  | |.....:...:..|. .|..||...
Human   687 ---SNNMDGIL----------EAVRVFGNLSQDHDV--CDFIVQNNVHRFMMALL-DAQHQDICF 735

  Fly   698 RTCAIGVLVNLLGDGEQRGPFLQLRGAELLSLLLRGSLEQEDWFLANIVCQALWNLLIDGHCAAN 762
            ..|  |||:||..|.::|....:..|.:.|...|| .|...||.||.:||:.||| ..:....|:
Human   736 SAC--GVLLNLTVDKDKRVILKEGGGIKKLVDCLR-DLGPTDWQLACLVCKTLWN-FSENITNAS 796

  Fly   763 LCQSSNILDEVSDLLADYLDEDRLSPGDDDNDNDEDDPEREAEDLDASDTDPEAHDALWE-DFAL 826
            .|..:...:.:..||:.:|||:....|..|.|.                  ...|...|| :|..
Human   797 SCFGNEDTNTLLLLLSSFLDEELALDGSFDPDL------------------KNYHKLHWETEFKP 843

  Fly   827 VATDLLERIQNN 838
            ||..||.|||.:
Human   844 VAQQLLNRIQRH 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32668	NP_727502.1	armadillo repeat	571..611	CDD:293788	8/39 (21%)
		armadillo repeat	619..665	CDD:293788	13/49 (27%)
		armadillo repeat	670..708	CDD:293788	10/38 (26%)
ARMC2	NP_115507.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..115		39/131 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..252		6/37 (16%)
		ARM 1	262..301		6/43 (14%)
		ARM 2	304..344		11/39 (28%)
		ARM 3	363..403		12/39 (31%)
		ARM 4	408..449		10/43 (23%)
		ARM 5	462..503		13/42 (31%)
		ARM 6	506..547		13/45 (29%)
		ARM 7	551..589		5/37 (14%)
		ARM 8	591..616		11/25 (44%)
		ARM 9	619..662		12/45 (27%)
		ARM 10	664..705		15/53 (28%)
		armadillo repeat	669..705	CDD:293788	13/48 (27%)
		ARM	673..790	CDD:237987	40/136 (29%)
		ARM 11	707..746		12/43 (28%)
		armadillo repeat	711..744	CDD:293788	9/35 (26%)
		ARM 12	748..790		15/43 (35%)
		armadillo repeat	751..787	CDD:293788	13/36 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141425
Domainoid	1	1.000	194	1.000	Domainoid score	I3170
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	195	1.000	Inparanoid score	I3833
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52272
OrthoDB	1	1.010	-	-		D193557at33208
OrthoFinder	1	1.000	-	-		FOG0007922
OrthoInspector	1	1.000	-	-		oto89465
orthoMCL	1	0.900	-	-		OOG6_105703
Panther	1	1.100	-	-	LDO	PTHR21356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5211
SonicParanoid	1	1.000	-	-		X5874
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840