DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32668 and Pkp3

DIOPT Version :9

Sequence 1:	NP_727502.1	Gene:	CG32668 / 318147	FlyBaseID:	FBgn0052668	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_001156396.1	Gene:	Pkp3 / 56460	MGIID:	1891830	Length:	822	Species:	Mus musculus

Alignment Length:	951	Identity:	193/951 - (20%)
Similarity:	290/951 - (30%)	Gaps:	351/951 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RRSRSETRPQANPAEMAKQPADSDKSDRQQQLAKHHQMRHHQPHASEQSLNKLGLVSSGTSGMGR 71
            |.:|.:.:.:|...::.:|...:..::..........|...|.|..:...      ||.:.||..
Mouse    67 RAARVQEQVRARLLQLGQQSRHNGSAELDGSAESARGMPRGQYHTMQTGF------SSRSQGMSG 125

  Fly    72 RKTSA------ELISEAKMFLGESVNAVPLLATGGARLVSTR----------------------R 108
            .|||.      ...|.|..   .|.:||.|  |...||.|..                      |
Mouse   126 DKTSTFRPIAKPAYSPASW---SSRSAVDL--TCSRRLSSAHNGGSAFGAVGYGGTQPTPPMPTR 185

  Fly   109 PITPRESG----RVLYGKVALAG--RPPSAFSMRY------LQNEKPSTPR----QLPALSGSVS 157
            |::..|.|    |..|..::|..  ..|.....||      |:....||.|    :..|.|||
Mouse   186 PVSFHERGGAASRADYDTLSLRSLRLGPGGLDDRYSVVSEQLEPAAASTYRAYAYERQASSGS-- 248

  Fly   158 ATPMPTRNGALLCQSSTE-------------TLIELLKQH-----------SGLKDCS-DETVQH 197
                 :|.|.|....:||             ||......|           :||:..: ..:|:.
Mouse   249 -----SRAGGLDWPEATEGPPSRTIRAPAMRTLQRFQSSHRSRGGTGSVSGAGLEPVARAPSVRS 308

  Fly   198 INAILQ-----------ELYTRVRKQERNYKRGF--------------------ILGGLYGLVEC 231
            ::..|.           :.||..|..:| ...||                    :||..|....|
Mouse   309 LSLSLADSGHLPDVRGLDSYTGHRTLQR-LSSGFDDIDLPSAVKYLMASDPNLQVLGAAYIQHRC 372

  Fly   232 TS-------PRVLLAVARVVL----ALRVTGSNLTGACK-LIFKVARHEQHDALFHEHDVLELLI 284
            .|       .|.|.||.|:|.    |.:....:.|||.: ||:....::.  ||..|:.:.|||
Mouse   373 YSDAAAKKQARSLQAVPRLVKLFNHANQEVQRHATGAMRNLIYDNVDNKL--ALVEENGIFELL- 434

  Fly   285 DGLGHASPLDEPEACIYAYGCIRFLTASSAQERDDALNRNWIGLETSGESQSLPIPALMPPALSA 349
                                       .:.:|:||.|.:|..|:..:
Mouse   435 ---------------------------RTLREQDDELRKNVTGILWN------------------ 454

  Fly   350 ISTSLCPRKLTGQQTLVSRLARHGAVELMILHLQMLNEAGATKRLQGPPL--------HTLYQLS 406
                     |:....|..||||....:|..|.|..|:.||      ||||        ...|..:
Mouse   455 ---------LSSSDHLKDRLARDTLEQLTDLVLSPLSGAG------GPPLIQQNASEAEIFYNAT 504

  Fly   407 AAMRALADVSQQQQRLQLQLQLACPHLIRAAEVSMGELEVQANVVRTLSVLSEDSDCCETLHNYA 471
            ..:|.|:..||..:    |....|..|:                           |...|..|:|
Mouse   505 GFLRNLSSASQATR----QKMRECHGLV---------------------------DALVTYINHA 538

  Fly   472 ARIGLLLGPSCAGGGQWSERLLAVLSRLGYMLGNILAKHESARIQYFHNDVAMEYLLNVLEQLNE 536
            ..:|.....|.       |..:.||..|.|.|                              .:|
Mouse   539 LDVGKCEDKSV-------ENAVCVLRNLSYRL------------------------------YDE 566

  Fly   537 RSPSSVAHLDAQIKLIRVVANMSVNPEVGAGLGNVRSLGAVLLQLLSKTSEELTKKKSPEQQELL 601
            ..||::..|:.:.:  |.:|.......||......|.|..:.|...:.|..|::  |.|:..|.|
Mouse   567 MPPSALQRLEGRGR--RDMAGAPPGEMVGCFTPQSRRLRELPLTADALTFAEVS--KDPKGLEWL 627

  Fly   602 HA--TLGALHNLCFYQDKQAAVQPLAEGSLQSLI--DDLSASLAKVLGNCQTSVTKVELARVLGN 662
            .:  .:|..:.|....:........|.|:||::.  |...|.:...|...|..:....|.||  .
Mouse   628 WSPQIVGLYNRLLQRCELNRHTTEAAAGALQNITAGDRRWAGVLSRLALEQERILNPLLDRV--R 690

  Fly   663 LTRNEQARRCFCAAGGLPLMVQQLTKQAAGQDYELRTCAIGVLVNLL--GDGEQRGPFLQLRGAE 725
            ...:.|.|       .|..:::.|::.|..:| |:.|..:..|:..|  ..||:..|      ||
Mouse   691 TADHNQLR-------SLTGLIRNLSRNARNKD-EMSTKVVSHLIEKLPGSVGEKCPP------AE 741

  Fly   726 LLSLLLRGSLEQEDWFLANIVCQALWNLLIDGHCAANLCQSSNILDEVSDLLADYLD-------- 782
            :               |.||:. .|.||::....||.            |||  |.|
Mouse   742 V---------------LVNIIA-VLNNLVVASPIAAR------------DLL--YFDGLRKLVFI 776

  Fly   783 -EDRLSPGDDDNDNDEDDPEREAEDLDASDTDPEAHDALWE 822
             :.|.||       |.:...|.|..|.|:         ||:
Mouse   777 KKKRDSP-------DSEKSSRAASSLLAN---------LWQ 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32668	NP_727502.1	armadillo repeat	571..611	CDD:293788	10/41 (24%)
		armadillo repeat	619..665	CDD:293788	11/47 (23%)
		armadillo repeat	670..708	CDD:293788	8/37 (22%)
Pkp3	NP_001156396.1	ARM	346..457	CDD:237987	30/167 (18%)
		armadillo repeat	346..371	CDD:293788	3/24 (13%)
		armadillo repeat	379..415	CDD:293788	11/35 (31%)
		armadillo repeat	421..455	CDD:293788	12/90 (13%)
		ARM	422..560	CDD:237987	45/238 (19%)
		armadillo repeat	474..510	CDD:293788	11/41 (27%)
		armadillo repeat	518..559	CDD:293788	12/78 (15%)
		armadillo repeat	673..707	CDD:293788	8/42 (19%)
		ARM	674..801	CDD:237987	42/188 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900