DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32668 and armc2

DIOPT Version :9

Sequence 1:	NP_727502.1	Gene:	CG32668 / 318147	FlyBaseID:	FBgn0052668	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_683582.4	Gene:	armc2 / 555846	ZFINID:	ZDB-GENE-041014-7	Length:	812	Species:	Danio rerio

Alignment Length:	908	Identity:	238/908 - (26%)
Similarity:	369/908 - (40%)	Gaps:	269/908 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 RRKTSAELISEAKMFLGESVNAVPLLATGGARLVSTRRPITPRESGRVLYGKV---ALAGRPPSA 132
            ||:||||::|||:..|               |.::|:||.||:|..|.|:|:.   |..||||||
Zfish    21 RRQTSAEIVSEARRSL---------------RSLATQRPFTPQEKNRQLFGESSSRARDGRPPSA 70

  Fly   133 FSM--RYLQ--NEKPSTPRQL------PALSGSV--------SATPMP------TRNGA------ 167
            ||:  |:.:  :.:|.:..:|      |.:|.|:        :|.|.|      ||.|:
Zfish    71 FSLHARHFEAPDSRPGSGTRLSPLEHKPRVSVSLDEDGGDDEAAHPKPPVERGGTRTGSGGSRAR 135

  Fly   168 LL--------------------------------------------CQSSTETLIELLKQH---- 184
            ||                                            .:||:||  :|.||.
Zfish   136 LLRATSVSKIPPMTPNAKNMSPEARIGGDQPDDGDNLHSADITEHKTKSSSET--DLHKQRRPQI 198

  Fly   185 -----SGLK----DCSDETV---QHINAILQE----------------------------LYTRV 209
                 ||.|    |..||:|   ..:..:|||                            |..|.
Zfish   199 DVSSPSGSKPDADDSEDESVFWNTKVLPVLQEFESFAGGDAVSDEIVGQLCNSCNGLHDALAERG 263

  Fly   210 RKQERNYKRGFILGGLYGLVECTSPRVLLAVARVVLALRVTGSNLTGACKLIFKVARHEQHDALF 274
            ....:..||..||..|:.|::..|.|:.|.:|:::|||.|:|:||...|||:||::|:..:||||
Zfish   264 MLGRQCKKRSGILRILFRLIDVGSDRLNLTLAKLILALNVSGNNLLNICKLVFKISRNANNDALF 328

  Fly   275 HEHDVLELLIDGLGHASPLDEPEACIYAYGCIRFLTASSAQERDDALNRNWIGLETSGESQSLPI 339
            ....:|:.|:..|.......:.||.:|..|.::.|:.:||..| ..|::.:||:......:.:..
Zfish   329 LNGSILDSLVSLLQCEDVWSKGEAVLYCVGSLKLLSGNSALSR-LLLDKGFIGVLMQLSKRLMHS 392

  Fly   340 PALMPPALSAISTSLCPRKLTGQ-QTLVSRLARHGAVELMILHLQMLNEAGATKRLQGPPLHTLY 403
            |       ||.|.::...:..|: |.:::.                               |.|.
Zfish   393 P-------SATSANVNTHRSDGEGQQIITG-------------------------------HILV 419

  Fly   404 QLSAAMRALADVSQQQQRLQLQLQLACPHLIRAAEVSMGELEVQANVVRTLSVLSEDSDCCETLH 468
            |::||:|.:||  |.:.|.......|...|....|....:|:|..||.|..|.||..::||..|.
Zfish   420 QVTAALRNIAD--QSESRPSFLSNKAFSTLCLILENHRNDLDVCINVARIFSKLSTYTECCHALA 482

  Fly   469 NYAARIGL---LLGPSCAGGGQWSERLLAVLSRLGYMLGNILAKHESARIQYFHNDVAMEYLLNV 530
            .......|   |||.        ..|...::.||.:.|||:.||...||.|.:..:..|:.||::
Zfish   483 ETPRCCSLFLELLGK--------HSRKQDLVVRLLFTLGNLTAKSTEAREQVYEEERGMDVLLDL 539

  Fly   531 LEQL-NERSPS----SVAHLDAQIKLIRVVANMSVNPEVGAGLGNVRSLGAVLLQLLSKTSEELT 590
            .:.. |..||.    |....|..:||||::||::::|.||..|    :...:.:|||   .|.|.
Zfish   540 FQAYQNTSSPPEQRLSPEREDVLVKLIRLLANLAIHPTVGTAL----AANTLCVQLL---LEVLE 597

  Fly   591 KKKSPEQQELLHATLGALHNLCFYQDKQAAVQPLAEGSLQSLIDDLSASLAKVLGNCQTSVTKVE 655
            .:...|.:||:...:..::||.||..:.:.::     |..:.|..|...|  :||:...:|  :|
Zfish   598 CRSVQESEELVINAVATINNLSFYPSQSSVIR-----SQHTHISQLLLKL--LLGSSMDAV--LE 653

  Fly   656 LARVLGNLTRNEQARRCFCAAGGLPLMVQQLTKQ-------AAGQDYELRTCAIGVLVNLLGDGE 713
            ..||.|||::.:..||         .::|...:|       :...|.....|  |||:||..|.:
Zfish   654 ATRVFGNLSQIKDVRR---------FVMQHKVEQFVITLLDSKSPDVCFSAC--GVLINLSADPD 707

  Fly   714 QRGPFLQLRGA--ELLSLLLRGSLEQEDWFLANIVCQALWNLLIDG---HCAANLCQSSNILDEV 773
            .|. .|...||  :|:..|  .....:||.||.:|||.|||..:||   |.           .|:
Zfish   708 NRA-MLSAEGAVQKLVDCL--RDFGPQDWHLAAVVCQTLWNCSLDGELQHA-----------QEL 758

  Fly   774 SDLLADYLDEDRLSPGDDDNDNDEDDPEREAEDLDASDTDPEAHDALWE-DFALVATDLLERI 835
            .::|..|.|                   |||....:.|...:..:|.|| .|..||..|.:|:
Zfish   759 LEILRLYTD-------------------REALQWPSEDGVRQVQEARWELLFLPVAERLRQRL 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32668	NP_727502.1	armadillo repeat	571..611	CDD:293788	8/39 (21%)
		armadillo repeat	619..665	CDD:293788	13/45 (29%)
		armadillo repeat	670..708	CDD:293788	9/44 (20%)
armc2	XP_683582.4	ARM	491..619	CDD:237987	41/142 (29%)
		ARM	651..745	CDD:237987	33/109 (30%)
		armadillo repeat	668..704	CDD:293788	11/46 (24%)
		armadillo repeat	709..745	CDD:293788	14/38 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574378
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3619
OMA	1	1.010	-	-		QHG52272
OrthoDB	1	1.010	-	-		D193557at33208
OrthoFinder	1	1.000	-	-		FOG0007922
OrthoInspector	1	1.000	-	-		oto40155
orthoMCL	1	0.900	-	-		OOG6_105703
Panther	1	1.100	-	-	LDO	PTHR21356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5874
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.810