DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG32668 and PKP2

DIOPT Version :10

Sequence 1:NP_727502.1 Gene:CG32668 / 318147 FlyBaseID:FBgn0052668 Length:863 Species:Drosophila melanogaster
Sequence 2:NP_004563.2 Gene:PKP2 / 5318 HGNCID:9024 Length:881 Species:Homo sapiens


Alignment Length:530 Identity:108/530 - (20%)
Similarity:176/530 - (33%) Gaps:159/530 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   303 YGCIRFLTASSAQERDDALNRNWIGLETSGESQSLPIPALMPPALSAISTSLCPRKLTGQQTLVS 367
            ||.||           ..|.:..:| :....|.:||..|.:..|.|:.......:.|..|:.:..
Human    10 YGYIR-----------TVLGQQILG-QLDSSSLALPSEAKLKLAGSSGRGGQTVKSLRIQEQVQQ 62

  Fly   368 RLARHG-------------AVELMILHLQMLNEAGATKRLQGPPLHTLYQLSAAM-------RAL 412
            .|||.|             :|...:.:|.::.......|...|..:.:.:.....       |..
Human    63 TLARKGRSSVGNGNLHRTSSVPEYVYNLHLVENDFVGGRSPVPKTYDMLKAGTTATYEGRWGRGT 127

  Fly   413 ADVSQQQQRLQLQLQLACPHLIRAAEVSMGELEVQANVVRTLSVLSEDSDCCETLHNYAARIGLL 477
            |..|.|:...:..|:    |.:|..|:|......:|:...:....|:.|....|||:..:|...|
Human   128 AQYSSQKSVEERSLR----HPLRRLEISPDSSPERAHYTHSDYQYSQRSQAGHTLHHQESRRAAL 188

  Fly   478 LGPSCAGGGQWSERLLAVLSRLGYMLGNILAKH-ESARIQYFHNDVA-------------MEY-- 526
            |.|.     :::...:..:||.|   .....:| ::...||.|..|:             :.|  
Human   189 LVPP-----RYARSEIVGVSRAG---TTSRQRHFDTYHRQYQHGSVSDTVFDSIPANPALLTYPR 245

  Fly   527 ------LLNVLEQLNERSPSSVAHLDAQIKLIRVVANMSVNPEVGAGLGNVRSLGAVLLQLLSKT 585
                  :.|:||:.|        :|.|                 |..:|.||.|  |.||.:::.
Human   246 PGTSRSMGNLLEKEN--------YLTA-----------------GLTVGQVRPL--VPLQPVTQN 283

  Fly   586 SEELTKKKSPEQQELLHAT--------------LGALHNLCFYQDKQAAVQPLAEGSLQSLIDDL 636
                ...:|...|...|:|              .|...:|        .|...|.|...:|:.:.
Human   284 ----RASRSSWHQSSFHSTRTLREAGPSVAVDSSGRRAHL--------TVGQAAAGGSGNLLTER 336

  Fly   637 SASLAKVLGNCQTSVTKVELARVLGNLTRNEQARRCFCAAGGLPLMVQQLTKQAAGQDYELRTCA 701
            |......|||....:|   |.|.:..|..:..          ||      ::.:|...:....| 
Human   337 STFTDSQLGNADMEMT---LERAVSMLEADHM----------LP------SRISAAATFIQHEC- 381

  Fly   702 IGVLVNLLGDGEQRGPFLQLRGAELLSLLLRGSLEQEDWFLANIVCQALWNLLIDGHCAANLCQS 766
                   ....|.|....||||  :|.||....::.||  :...||.||.||:.:        .:
Human   382 -------FQKSEARKRVNQLRG--ILKLLQLLKVQNED--VQRAVCGALRNLVFE--------DN 427

  Fly   767 SNILDEVSDL 776
            .|.| ||::|
Human   428 DNKL-EVAEL 436

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32668NP_727502.1 armadillo repeat 571..611 CDD:293788 11/53 (21%)
armadillo repeat 619..665 CDD:293788 12/45 (27%)
armadillo repeat 670..708 CDD:293788 4/37 (11%)
PKP2NP_004563.2 Required for binding to single-stranded DNA. /evidence=ECO:0000269|PubMed:20613778 1..360 81/415 (20%)
Required for interaction with influenza A virus RNA polymerase subunit PB1. /evidence=ECO:0000269|PubMed:28169297 1..348 78/400 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..314 4/35 (11%)
ARM 1 341..383 11/68 (16%)
ARM 2 385..424 17/42 (40%)
armadillo repeat 388..424 CDD:293788 16/39 (41%)
ARM 3 427..467 5/11 (45%)
armadillo repeat 430..460 CDD:293788 4/8 (50%)
ARM 4 571..616
ARM 5 671..711
ARM 6 719..758
armadillo repeat 724..756 CDD:293788
ARM 7 763..804
armadillo repeat 764..804 CDD:293788
ARM 8 807..849
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.