DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32668 and Armc2

DIOPT Version :9

Sequence 1:	NP_727502.1	Gene:	CG32668 / 318147	FlyBaseID:	FBgn0052668	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_574794.3	Gene:	Armc2 / 499470	RGDID:	1562413	Length:	895	Species:	Rattus norvegicus

Alignment Length:	981	Identity:	240/981 - (24%)
Similarity:	385/981 - (39%)	Gaps:	314/981 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 HHQMRHHQPHASEQSLNKLGLVSSGTSGMGRRKTSAELISEAKMFLGESVNAVPLLATGGARLVS 105
            |..::.....:|||.|:||.  :.....:.::|||||:||||:       ||:        |.|.
  Rat    34 HSNLKGKMLSSSEQKLDKLD--AFYRLPLAKQKTSAEIISEAR-------NAL--------RTVR 81

  Fly   106 TRRPITPRESGRVLYGKVAL---AGRPPSAFSMR----YLQNEKPST------------------ 145
            |:||.||||..|.|:|..:.   ..||||:||:.    .|.:.||.:
  Rat    82 TQRPFTPREDQRKLFGPASSRTPENRPPSSFSLHASSFELADPKPISGTRLRPLELKPKAPASPN 146

  Fly   146 ---------------PRQLPALSG----------------------SVSATPMPT---------- 163
                           |.::..:||                      :.|.||:.:
  Rat   147 TEEDANLSFPKAPVDPAKIRRISGARARFYRAASQGTLLPDRSPPAAHSKTPVESRDTVSVGSAT 211

  Fly   164 --RNGALLCQSSTETLIE---LLKQHSGLKDCSD------------------------------- 192
              ||||.|..||....::   ||....|.::.::
  Rat   212 AKRNGAHLTASSATRHLKNPPLLPCDQGFRETTEQEASLQPQLGSRGDPGKRRARASSCPSSSDL 276

  Fly   193 ---ETVQHINAILQE------------------LYTRVRKQE----------------------- 213
               ||.....|.|||                  :...:.|:|
  Rat   277 SRQETRTASRASLQEQEPELEVDETFWKTRIIPILHELEKEEDIEAMCAACTQLHRALEEARMLG 341

  Fly   214 -RNYKRGFILGGLYGLVECTSPRVLLAVARVVLALRVTGSNLTGACKLIFKVARHEQHDALFHEH 277
             |..:|..:|..||.||:..|..:.|.:|:::|||:|:|.||...|||:||::|.|::|.|..:.
  Rat   342 KRFKRRSVLLKALYKLVDAGSDALSLKLAKLILALKVSGKNLLNICKLVFKISRSEKNDTLMQKD 406

  Fly   278 DVLELLIDGLGHASPLDEPEACIYAYGCIRFLTASSAQERDDALNRNWIGLETSGESQSLPIPAL 342
            ::|:.|::.|.........||.:|..|.::|::.|
  Rat   407 NILQSLLEVLRDEDLQSNTEAFLYCMGALKFISGS------------------------------ 441

  Fly   343 MPPALSAISTSLCPRKLTGQQTLVSRLARHGAVELMILHLQMLNEAGATKRLQGPPL----HTLY 403
                         |..||       .:...|.||:::   |::.|........|..|    |.|.
  Rat   442 -------------PGFLT-------EMVNKGTVEILV---QLIKETTEDTEKHGACLPNSGHLLV 483

  Fly   404 QLSAAMRALADVSQQQQRLQLQLQL-ACPHLIRAAEVSMGELEVQANVVRTLSVLSEDSDCCETL 467
            |.:|.:|.|.|....:.:|   |.: |.|.|.......|.:.::..|:.|..|.|:...|||..|
  Rat   484 QTTATLRNLVDSPLTRSKL---LNIGAFPCLCTVMGQHMNDKDICTNIARVFSKLTSYRDCCAAL 545

  Fly   468 HNYAARIGLLLGPSCAGGGQWSERLLAVLSRLGYMLGNILAKHESARIQYFHNDVAMEYLLNVLE 532
            .:|:....|.|  |.....|.::.|:.   |:.::|||:.||...||..:.....::|.||.:.:
  Rat   546 VSYSRCYALFL--SLLNKYQKNQDLVI---RIVFILGNLTAKSNQARELFSGESGSVETLLTLFQ 605

  Fly   533 ---QLNERSPS--------SVAHLDAQIKLIRVVANMSVNPEVGAGL-GNVRSLGAVLLQLLSKT 585
               :|.|.||.        .....|..:||.||:||::::|.:|..| .:.|.:|.:|..|.||:
  Rat   606 NFYRLEESSPKLQRSGARPRAEAEDVLVKLTRVLANIAIHPCIGPVLAADPRVVGLLLTTLESKS 670

  Fly   586 SEELTKKKSPEQQELLHATLGALHNLCFYQDKQAAVQP----LAEGSLQSLIDDLSASLAKVLGN 646
            ..:.        :||:..|..|::||.|||.|.:.:|.    :||..|:.|:   |.::..:|
  Rat   671 LGDC--------EELVINTTAAINNLSFYQVKSSVLQHRKLYVAELLLKLLV---SNNMDGIL-- 722

  Fly   647 CQTSVTKVELARVLGNLTRNEQARRCFCAAGGLPLMVQQLTK------QAAGQDYELRTCAIGVL 705
                    |..||.|||:::...    |..    ||.:.:.|      :|..||.....|  |||
  Rat   723 --------EAVRVFGNLSQDHDV----CNF----LMQKNVHKFLITLLEAKHQDICFSAC--GVL 769

  Fly   706 VNLLGDGEQRGPFLQLRGAELLSLLLRGSLEQEDWFLANIVCQALWNLLIDGHCAANLCQSSNIL 770
            :||..|.::|....:..|.:.|...|| .....||.||.:||:.||| ..:....|:.|...::.
  Rat   770 LNLTVDKDKRAVLKEGGGIKKLVDCLR-DFGPGDWQLACLVCKTLWN-FSENITNASECFGDDVT 832

  Fly   771 DEVSDLLADYLDEDRLSPGDDDNDNDEDDPEREAEDLDAS-DTDPEAHDAL-WE-DFALVATDLL 832
            :.:..||:.:|||:..                    ||:| |.|.:::..| || :|..||.:||
  Rat   833 NTLLILLSTFLDEELA--------------------LDSSFDQDLKSYHRLHWETEFKPVAQELL 877

  Fly   833 ERIQNN 838
            :|||::
  Rat   878 KRIQSH 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32668	NP_727502.1	armadillo repeat	571..611	CDD:293788	10/39 (26%)
		armadillo repeat	619..665	CDD:293788	13/49 (27%)
		armadillo repeat	670..708	CDD:293788	11/43 (26%)
Armc2	XP_574794.3	ARM	402..537	CDD:237987	37/190 (19%)
		armadillo repeat	656..688	CDD:293788	10/39 (26%)
		ARM	698..818	CDD:237987	41/144 (28%)
		armadillo repeat	734..774	CDD:293788	13/49 (27%)
		armadillo repeat	779..815	CDD:293788	12/36 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335104
Domainoid	1	1.000	204	1.000	Domainoid score	I2845
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3664
OMA	1	1.010	-	-		QHG52272
OrthoDB	1	1.010	-	-		D193557at33208
OrthoFinder	1	1.000	-	-		FOG0007922
OrthoInspector	1	1.000	-	-		oto96591
orthoMCL	1	0.900	-	-		OOG6_105703
Panther	1	1.100	-	-	LDO	PTHR21356
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5874
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810