DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32668 and Pkp3

DIOPT Version :9

Sequence 1:	NP_727502.1	Gene:	CG32668 / 318147	FlyBaseID:	FBgn0052668	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_008758204.1	Gene:	Pkp3 / 293619	RGDID:	1309133	Length:	836	Species:	Rattus norvegicus

Alignment Length:	986	Identity:	198/986 - (20%)
Similarity:	301/986 - (30%)	Gaps:	376/986 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SETRPQANPAEMA--------KQPADSDKSDR------QQQ-----LAKHHQMRHH--------- 47
            |..:|:|....:|        ::.|:..::||      |:|     |....|.||:
  Rat     9 SALQPEAGVCSLALPSDLQLDRRGAEGPEADRLRAARVQEQVRARLLQLGQQSRHNGSTELDGSA 73

  Fly    48 ---------QPHASEQSLNKLGLVSSGTSGMGRRKTS------------AELISEAKMFL----- 86
                     |.|..:...      ||.:.||...|||            |...|.:.:.|
  Rat    74 ESTRGLPRGQYHTMQSGF------SSRSQGMSGDKTSTFRPIAKPAYNPASWSSRSAVDLTCSRR 132

  Fly    87 -------GESVNAVPLLATGGARLV--STRRPITPRESG----RVLYGKVALAG--RPPSAFSMR 136
                   |.:..||   ..|||:..  ...||::..|.|    |..|..::|..  ..|.....|
  Rat   133 LSSAHNGGSAFGAV---GYGGAQPTPPMPTRPVSFHERGGAASRADYDTLSLRSLRLGPGGLDDR 194

  Fly   137 Y---LQNEKPSTPRQLPALSGSVSATPMPTRNGALLCQSSTE-------------TLIELLKQH- 184
            |   .:..:|:......|.:....|:...:|.|.|....:||             ||......|
  Rat   195 YSVVSEQLEPAAASTYRAYAYERQASSSSSRAGGLDWPEATEGPPSRTIRAPAMRTLQRFQSSHR 259

  Fly   185 ----------SGLKDCS-DETVQHINAIL-----------QELYTRVRKQERNYKRGF------- 220
                      :||:..: ..:|:.::..|           .:.||..|..:| ...||
  Rat   260 SRGGTGSVSGAGLEPVARAPSVRSLSLSLGDSGHLPDVRGLDSYTGHRTLQR-LSSGFDDIDLPS 323

  Fly   221 -------------ILGGLYGLVECTS-------PRVLLAVARVVL----ALRVTGSNLTGACK-L 260
                         :||..|....|.|       .|.|.||.|:|.    |.:....:.|||.: |
  Rat   324 AVKYLMASDPNLQVLGAAYIQHRCYSDAAAKKQARSLQAVPRLVKLFNHANQEVQRHATGAMRNL 388

  Fly   261 IFKVARHEQHDALFHEHDVLELLIDGLGHASPLDEPEACIYAYGCIRFLTASSAQERDDALNRNW 325
            |:....::.  ||..|:.:.|||                            .:.:|:||.|.:|.
  Rat   389 IYDNVDNKL--ALVEENGIFELL----------------------------RTLREQDDELRKNV 423

  Fly   326 IGLETSGESQSLPIPALMPPALSAISTSLCPRKLTGQQTLVSRLARHGAVELMILHLQMLNEAGA 390
            .|:..:                           |:....|..||||....:|..|.|..|:.||
  Rat   424 TGILWN---------------------------LSSSDHLKDRLARDTLEQLTDLVLSPLSGAG- 460

  Fly   391 TKRLQGPPL--------HTLYQLSAAMRALADVSQQQQRLQLQLQLACPHLIRAAEVSMGELEVQ 447
                 ||||        ...|..:..:|.|:..||..:    |....|..|:
  Rat   461 -----GPPLIQQNASEAEIFYNATGFLRNLSSASQATR----QKMRECHGLV------------- 503

  Fly   448 ANVVRTLSVLSEDSDCCETLHNYAARIGLLLGPSCAGGGQWSERLLAVLSRLGYMLGNILAKHES 512
                          |...|..|:|..:|.....|.       |..:.||..|.|.|
  Rat   504 --------------DALVTYINHALDVGKCEDKSV-------ENAVCVLRNLSYRL--------- 538

  Fly   513 ARIQYFHNDVAMEYLLNVLEQLNERSPSSVAHLDAQIKLIRVVANMSVNPEVGAGLGNVRSLGAV 577
                                 .:|..||::..|:.:.:  |.:|.......||......|.|..:
  Rat   539 ---------------------YDEMPPSALQRLEGRGR--RDMAGAPPGEVVGCFTPQSRRLREL 580

  Fly   578 LLQLLSKTSEELTKKKSPEQQELLHA--TLGALHNLCFYQDKQAAVQPLAEGSLQSLI--DDLSA 638
            .|...:.|..|::  |.|:..|.|.:  .:|..:.|....:........|.|:||::.  |...|
  Rat   581 PLTADALTFAEVS--KDPKGLEWLWSPQIVGLYNRLLQRCELNRHTTEAAAGALQNITAGDRRWA 643

  Fly   639 SLAKVLGNCQTSVTKVELARVLGNLTRNEQARRCFCAAGGLPLMVQQLTKQAAGQDYELRTCAIG 703
            .:...|...|..:....|.||  ....:.|.|       .|..:::.|::.|..:| |:.|..:.
  Rat   644 GVLSRLALEQERILNPLLDRV--RTADHNQLR-------SLTGLIRNLSRNARNKD-EMSTKVVS 698

  Fly   704 VLVNLL--GDGEQRGPFLQLRGAELLSLLLRGSLEQEDWFLANIVCQALWNLLIDGHCAANLCQS 766
            .|:..|  ..||:..|      ||:               |.||:. .|.||::....||.
  Rat   699 HLIEKLPGSVGEKCPP------AEV---------------LVNIIA-VLNNLVVASPIAAR---- 737

  Fly   767 SNILDEVSDLLADYLD---------EDRLSPGDDDNDNDEDDPEREAEDLDASDTDPEAHDALWE 822
                    |||  |.|         :.|.||       |.:...|.|..|.|:         ||:
  Rat   738 --------DLL--YFDGLRKLVFIKKKRDSP-------DSEKSSRAASSLLAN---------LWQ 776

  Fly   823 ------DFALV 827
                  ||..|
  Rat   777 YSKLHRDFRAV 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32668	NP_727502.1	armadillo repeat	571..611	CDD:293788	10/41 (24%)
		armadillo repeat	619..665	CDD:293788	11/47 (23%)
		armadillo repeat	670..708	CDD:293788	8/37 (22%)
Pkp3	XP_008758204.1	ARM	321..432	CDD:237987	30/167 (18%)
		armadillo repeat	321..346	CDD:293788	3/24 (13%)
		armadillo repeat	354..390	CDD:293788	11/35 (31%)
		armadillo repeat	396..430	CDD:293788	12/90 (13%)
		ARM	397..535	CDD:237987	45/238 (19%)
		armadillo repeat	449..485	CDD:293788	11/41 (27%)
		armadillo repeat	493..534	CDD:293788	12/78 (15%)
		armadillo repeat	648..682	CDD:293788	8/42 (19%)
		ARM	649..776	CDD:237987	42/188 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900