DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32668 and Ctnnd2

DIOPT Version :9

Sequence 1:	NP_727502.1	Gene:	CG32668 / 318147	FlyBaseID:	FBgn0052668	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_032755.2	Gene:	Ctnnd2 / 18163	MGIID:	1195966	Length:	1246	Species:	Mus musculus

Alignment Length:	758	Identity:	146/758 - (19%)
Similarity:	227/758 - (29%)	Gaps:	286/758 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PADSDKSDRQQQLAKHHQMRHHQPH------ASEQSLNKLGLVSSGTSGMGRRKTSAELISEAKM 84
            |.|...|:|...|::.....:.:|.      ||..|...|.|..:..|.:..|.|.|..
Mouse   138 PQDYSTSERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLALGDTAPSQLPARSTQARA------ 196

  Fly    85 FLGESVNAVPLLATGGARLVSTRRPI----TPRESGRVLYGKV-ALAGRPPSAFSMRYLQNEKPS 144
             .|:|.:..   .||.|..::...|.    .|||......|.. .|...||:|.::.|..:..|:
Mouse   197 -AGQSFSQG---TTGRAGHLAGSEPAPPPPPPREPFAPSLGSAFHLPDAPPAAAALYYSSSTLPA 257

  Fly   145 TPRQLPALS------------------GSVSATP---MPTRNGALLCQS-STETLIELLKQHSGL 187
            .||....|:                  |:..|.|   .|.::.:.|.:| ||.:.|.::...:||
Mouse   258 PPRGGSPLTTTQGGSPTKLQRGGSAPEGAAYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGL 322

  Fly   188 ---KDCSDETVQHI--NAILQELYTRVRKQERNYKRGFILGGLYGLVECTSPRV----------- 236
               :..|..|||..  ::.:.:|.:.:              |.|..:..|...|
Mouse   323 SPIRVTSPPTVQSTISSSPIHQLSSTI--------------GTYATLSPTKRLVHASEQYSKHSQ 373

  Fly   237 -LLAVARVVLALRVTGSNLTGACKLIFKVARHEQHDALFHEHDVLELLIDGLGHASPLDEPEACI 300
             |.|.|    .|:..||...|:     :.:...||..|..|   |..|.....|..|:.|..  :
Mouse   374 ELYATA----TLQRPGSLAAGS-----RASYSSQHGHLAPE---LRALQSPEHHIDPIYEDR--V 424

  Fly   301 YAYGCIRFLTASSAQERDDALNRNWIGLETSGESQSLPIPALMPPALSAISTSLCPR-------- 357
            |....:|.|:                      :||..|:|   |.......||..|.
Mouse   425 YQKPPMRSLS----------------------QSQGDPLP---PAHTGTFRTSTAPSSPGVDSVP 464

  Fly   358 -KLTGQQTLVSRLARHGAVELMILHLQMLNEAGATKRLQGPPLHTLYQLSAAMRALADVSQQQQR 421
             :.||.|        ||.          .|.|.|          |..:.|.|....::.:...::
Mouse   465 LQRTGSQ--------HGP----------QNAAAA----------TFQRASYAAGPASNYADPYRQ 501

  Fly   422 LQLQLQLACPHLIRAAEVSMGELEVQANVVRTLSVLSEDSDCCETLHNYAARIGLLLGPSCAGGG 486
            ||....:..|:     ..|...|..:..:.|:.|:.|...|                 |...|
Mouse   502 LQYCASVDSPY-----SKSGPALPPEGTLARSPSIDSIQKD-----------------PREFG-- 542

  Fly   487 QWSERLLAVLSRLGYMLGNILAKHESARIQYFHNDVAMEYLLNVLEQLNERSPSSVAHLDAQIKL 551
             |.:                                  ..|..|::.|..:.||
Mouse   543 -WRD----------------------------------PELPEVIQMLQHQFPS----------- 561

  Fly   552 IRVVANMSVNPEVGAGLGNVRSLGAVLLQLLSKTSEELTKKKSPEQQELLHATLGALHNLCFYQD 616
                               |:|..|..||                             :|||..:
Mouse   562 -------------------VQSNAAAYLQ-----------------------------HLCFGDN 578

  Fly   617 K-QAAVQPLAEGSLQSLIDDLSASLAKVLGNCQTSVTKVELARVLGNLT---RNEQARRCFCAAG 677
            | :|.::  .:|.:|.|:|        :|.:..|.|.: .....|.||.   .|:..:......|
Mouse   579 KIKAEIR--RQGGIQLLVD--------LLDHRMTEVHR-SACGALRNLVYGKANDDNKIALKNCG 632

  Fly   678 GLPLMVQQLTKQAAGQDYELRTCAIGVLVNLLGDGEQRGPFLQ 720
            |:|.:|:.|.|..   |.|:|....|||.||......:.|.:|
Mouse   633 GIPALVRLLRKTT---DLEIRELVTGVLWNLSSCDALKMPIIQ 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32668	NP_727502.1	armadillo repeat	571..611	CDD:293788	5/39 (13%)
		armadillo repeat	619..665	CDD:293788	11/48 (23%)
		armadillo repeat	670..708	CDD:293788	12/37 (32%)
Ctnnd2	NP_032755.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..237		25/108 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..308		10/52 (19%)
		ARM 1	390..432		11/51 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..479		16/93 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..532		4/18 (22%)
		ARM 2	536..575		15/151 (10%)
		ARM	540..662	CDD:237987	42/231 (18%)
		armadillo repeat	548..573	CDD:293788	10/83 (12%)
		ARM 3	578..617		12/49 (24%)
		armadillo repeat	581..617	CDD:293788	11/46 (24%)
		ARM 4	622..662		14/42 (33%)
		armadillo repeat	625..660	CDD:293788	12/37 (32%)
		armadillo repeat	667..718	CDD:293788	2/6 (33%)
		ARM 5	678..720
		ARM 6	724..769
		ARM 7	831..871
		armadillo repeat	834..871	CDD:293788
		ARM	835..962	CDD:237987
		ARM 8	903..942
		armadillo repeat	906..940	CDD:293788
		ARM	907..1039	CDD:237987
		armadillo repeat	947..993	CDD:293788
		ARM 9	996..1039
		armadillo repeat	999..1034	CDD:293788
		CAF20	<1050..1109	CDD:293657
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1063..1130
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1151..1175
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900