DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32668 and CTNND1

DIOPT Version :9

Sequence 1:	NP_727502.1	Gene:	CG32668 / 318147	FlyBaseID:	FBgn0052668	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_001078927.1	Gene:	CTNND1 / 1500	HGNCID:	2515	Length:	968	Species:	Homo sapiens

Alignment Length:	1025	Identity:	187/1025 - (18%)
Similarity:	314/1025 - (30%)	Gaps:	393/1025 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AEMAKQPADSDKSDRQ-QQLAKHHQMRHHQPHASEQSLNKLGLVSSGTSGMGRRKTSAELISEAK 83
            |.:.:|.|..:|..|. ::..:|...:..:...|.|..|.  |:::||  :.||..:...:.:|.
Human    14 ASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANP--LMANGT--LTRRHQNGRFVGDAD 74

  Fly    84 MFLGESVNAVPLLATGGARLVSTRRPITPRESGRVLYGKVALAGRPPSAFSMRYLQNEKPSTPRQ 148
            :   |......|...|            |::...:||..:... :.|......|.: |.|
Human    75 L---ERQKFSDLKLNG------------PQDHSHLLYSTIPRM-QEPGQIVETYTE-EDP----- 117

  Fly   149 LPALSGSVSATPMPTRNGALLCQSSTETLIELLKQHSGLKDCSDETVQHI--------------- 198
                .|::|...:.|.:..  ....|||.::.:     :|..:..|||.:
Human   118 ----EGAMSVVSVETSDDG--TTRRTETTVKKV-----VKTVTTRTVQPVAMGPDGLPVDASSVS 171

  Fly   199 NAILQELYTRVRKQ----------------------------ERNYKRGFILGG----------- 224
            |..:|.|....||.                            .|:|:.|:..|.
Human   172 NNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYEDGYPGGSDNYGSLSRVTR 236

  Fly   225 -------------------LYGLVECTSPRVLLAVARVVLALRVTGSNLTGACKLIFKVARHEQH 270
                               :||    ..|:|           ||.||:          |..|..|
Human   237 IEERYRPSMEGYRAPSRQDVYG----PQPQV-----------RVGGSS----------VDLHRFH 276

  Fly   271 DALFH-EHDVLELLIDGLGHASPLDEPEACIYAYGCIRFL-TASSAQER----DDALNRN----- 324
            ...:. |.|...:..|.|.:....|        ||..|.. |.|..:.|    :|.:...
Human   277 PEPYGLEDDQRSMGYDDLDYGMMSD--------YGTARRTGTPSDPRRRLRSYEDMIGEEVPSDQ 333

  Fly   325 --WIGL--ETSGESQSL--------PIPALMPPALSAISTSLCPRKLTGQQTLVSRLARHGAVEL 377
              |..|  ...|...||        |.|....|.|..:...|..|        :..:..:.|..|
Human   334 YYWAPLAQHERGSLASLDSLRKGGPPPPNWRQPELPEVIAMLGFR--------LDAVKSNAAAYL 390

  Fly   378 MILHLQMLNEAGAT--KRLQGPPL------HTLYQLS-AAMRALADVS---QQQQRLQLQLQLAC 430
            .  ||...|:...|  ::|:|.|:      |...::. .|..||.::|   .|..::.::.....
Human   391 Q--HLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGV 453

  Fly   431 PHLIR---------AAEVSMGEL-------EVQANVV-RTLSVLS------------EDSDCCET 466
            |.|:|         ..||..|.|       .::..:| ..|..|:            |.::.|:.
Human   454 PALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKP 518

  Fly   467 LHNYAARIGLLLGPSCAGGGQWSERLLAVLSRLGYMLGNILAKHESARIQYFHNDVAMEYLLNVL 531
            .|.                 :|.    :||:.....|.|:.::...||.:....|..::.|:.::
Human   519 RHI-----------------EWE----SVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIV 562

  Fly   532 EQLNERSPSSVAHLDAQIKLIR----VVANMS--VNPEV-------------------------G 565
            :       :.:...|:..||:.    ::.|:|  |:.|:                         |
Human   563 Q-------AEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFG 620

  Fly   566 AGLGNVR--SLGAVLLQLLSKTSEELTKKKSPE-------QQE----------------LLHATL 605
            |..|...  |.|...::..:..:.:..|:.||.       |.|                :|.|:.
Human   621 AKKGKDEWFSRGKKPIEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASA 685

  Fly   606 GALHNLC-------------FYQDKQ-AAVQPL-----------AEGSLQSLIDDLS-------- 637
            ||:.|||             ..|:|. :|:..|           |.|:|::|..|..
Human   686 GAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKH 750

  Fly   638 --ASLAKVL-GNCQTSV------TKVELARVLGN-LTRNEQARRCFCAAGGLPLMVQQLTKQAAG 692
              .:|.|.| |..|.|.      |.:.:...:.. :..|.:|.:......|:..:| .:.|....
Human   751 AIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLV-LINKSGNR 814

  Fly   693 QDYELRTCAIGVLVNLLGDGEQRGPFLQLRGAELLSLLLRGSLEQEDW----FLANIVCQALWNL 753
            .:.|:|..|: ||..:.|..|.|.|                 ||:|.|    |..|:
Human   815 SEKEVRAAAL-VLQTIWGYKELRKP-----------------LEKEGWKKSDFQVNL-------- 853

  Fly   754 LIDGHCAANLCQSSNILDEVSDLLADYLDEDRLSPGDDDNDNDEDDPERE 803
                 ..|:..|||:..|            |...|..|.|...:..|:||
Human   854 -----NNASRSQSSHSYD------------DSTLPLIDRNQKSDKKPDRE 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32668	NP_727502.1	armadillo repeat	571..611	CDD:293788	11/64 (17%)
		armadillo repeat	619..665	CDD:293788	14/74 (19%)
		armadillo repeat	670..708	CDD:293788	8/37 (22%)
CTNND1	NP_001078927.1	Necessary and sufficient for interaction with CCDC85B. /evidence=ECO:0000269\|PubMed:25009281	1..357		72/412 (17%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:P30999	299..306		3/14 (21%)
		ARM 1	358..395		10/46 (22%)
		ARM	363..481	CDD:237987	26/127 (20%)
		armadillo repeat	368..393	CDD:293788	5/34 (15%)
		ARM 2	398..437		8/38 (21%)
		armadillo repeat	401..437	CDD:293788	8/35 (23%)
		ARM 3	441..475		6/33 (18%)
		armadillo repeat	444..479	CDD:293788	7/34 (21%)
		ARM 4	476..516		5/39 (13%)
		armadillo repeat	486..537	CDD:293788	10/71 (14%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:P30999	521..528		2/27 (7%)
		ARM	524..>588	CDD:237987	12/74 (16%)
		ARM 5	534..573		7/45 (16%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:P30999	568..575		1/6 (17%)
		ARM 6	583..624		6/40 (15%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:P30999	622..629		1/6 (17%)
		ARM 7	653..693		8/39 (21%)
		armadillo repeat	656..693	CDD:293788	8/36 (22%)
		ARM	657..759	CDD:237987	20/101 (20%)
		ARM 8	700..739		8/38 (21%)
		armadillo repeat	703..737	CDD:293788	7/33 (21%)
		ARM 9	740..780		8/39 (21%)
		armadillo repeat	744..787	CDD:293788	7/42 (17%)
		ARM 10	781..826		8/46 (17%)
		armadillo repeat	793..829	CDD:293788	8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..944		12/44 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900