Protein Alignment CG32668 and PKP3

DIOPT Version :9

• Sequence 1: NP_727502.1
• Gene: CG32668 / 318147
• FlyBaseID: FBgn0052668
• Length: 863
• Species: Drosophila melanogaster
• Sequence 2: NP_001289958.1
• Gene: PKP3 / 11187
• HGNCID: 9025
• Length: 812
• Species: Homo sapiens
• Alignment Length: 931
• Identity: 182/931 - (19%)
• Similarity: 296/931 - (31%)
• Gaps: 311/931 - (33%)

  Fly     7 RRSRSETRPQANPAEMAKQPADSDKSDRQQQLAKHHQMRHHQPHASEQSLNKLGLVSSGTSGMGR 71
            |.:|.:.:.:|...::.:||..:..::.:.:..........|.|..:...:......||....|.
Human    57 RAARVQEQVRARLLQLGQQPRHNGAAEPEPEAETARGTSRGQYHTLQAGFSSRSQGLSGDKTSGF 121

  Fly    72 RKTSAELISEAKMFLGESVNAVPLLAT------------------GGARLV--STRRPITPRESG 116
            |..:....|.|..   .|.:||.|..:                  |||:..  ...||::..|.|
Human   122 RPIAKPAYSPASW---SSRSAVDLSCSRRLSSAHNGGSAFGAAGYGGAQPTPPMPTRPVSFHERG 183

  Fly   117 ----RVLYGKVALAG--RPPSAFSMRY-LQNE--KPSTPRQLPALSGSVSATPMPTRNGALLCQS 172
                |..|..::|..  ..|.....|| |.:|  :|:......|.:....|:...:|.|.|....
Human   184 GVGSRADYDTLSLRSLRLGPGGLDDRYSLVSEQLEPAATSTYRAFAYERQASSSSSRAGGLDWPE 248

  Fly   173 STE-------------TLIELLKQH--------------------------------SG-LKDC- 190
            :||             ||......|                                || |.|.
Human   249 ATEVSPSRTIRAPAVRTLQRFQSSHRSRGVGGAVPGAVLEPVARAPSVRSLSLSLADSGHLPDVH 313

  Fly   191 ------SDETVQHINAILQEL-----YTRVRKQERNYKRGFILGGLYGLVECTS-------PRVL 237
                  |..|:|.:::...::     ...:...:.|.:   :||..|...:|.|       .|.|
Human   314 GFNSYGSHRTLQRLSSGFDDIDLPSAVKYLMASDPNLQ---VLGAAYIQHKCYSDAAAKKQARSL 375

  Fly   238 LAVARVVL----ALRVTGSNLTGACK-LIFKVARHEQHDALFHEHDVLELLIDGLGHASPLDEPE 297
            .||.|:|.    |.:....:.|||.: ||:..|.::.  ||..|:.:.|||
Human   376 QAVPRLVKLFNHANQEVQRHATGAMRNLIYDNADNKL--ALVEENGIFELL-------------- 424

  Fly   298 ACIYAYGCIRFLTASSAQERDDALNRNWIGLETSGESQSLPIPALMPPALSAISTSLCPRKLTGQ 362
                          .:.:|:||.|.:|..|:..:                           |:..
Human   425 --------------RTLREQDDELRKNVTGILWN---------------------------LSSS 448

  Fly   363 QTLVSRLARHGAVELMILHLQMLNEAGATKRLQGPPL--------HTLYQLSAAMRALADVSQQQ 419
            ..|..||||....:|..|.|..|:.||      ||||        ...|..:..:|.|:..||..
Human   449 DHLKDRLARDTLEQLTDLVLSPLSGAG------GPPLIQQNASEAEIFYNATGFLRNLSSASQAT 507

  Fly   420 QRLQLQLQLACPHLIRAAEVSMGELEVQANVVRTLSVLSEDSDCCETLHNYAARIGLLLGPSCAG 484
            :    |....|..|:.|...|:..              :.|:..||
Human   508 R----QKMRECHGLVDALVTSINH--------------ALDAGKCE------------------- 535

  Fly   485 GGQWSERLLAVLSRLGYMLGNILAKHESARIQYFHNDVAMEYLLNVLEQLNERSPSSVAHLDAQI 549
             .:..|..:.||..|.|.|                              .:|..||::..|:.:.
Human   536 -DKSVENAVCVLRNLSYRL------------------------------YDEMPPSALQRLEGRG 569

  Fly   550 KLIRVVANMSVNPEVGAGLGNVRSLGAVLLQLLSKTSEELTKKKSPEQQELLHA--TLGALHNLC 612
            :  |.:|.......||......|.|..:.|...:.|..|::  |.|:..|.|.:  .:|..:.|.
Human   570 R--RDLAGAPPGEVVGCFTPQSRRLRELPLAADALTFAEVS--KDPKGLEWLWSPQIVGLYNRLL 630

  Fly   613 FYQDKQAAVQPLAEGSLQSLI--DDLSASLAKVLGNCQTSVTKVELARVLGNLTRNEQARRCFCA 675
            ...:........|.|:||::.  |...|.:...|...|..:....|.||  ....:.|.|
Human   631 QRCELNRHTTEAAAGALQNITAGDRRWAGVLSRLALEQERILNPLLDRV--RTADHHQLR----- 688

  Fly   676 AGGLPLMVQQLTKQAAGQDYELRTCAIGVLVNLL--GDGEQRGPFLQLRGAELLSLLLRGSLEQE 738
              .|..:::.|::.|..:| |:.|..:..|:..|  ..||:..|      ||:
Human   689 --SLTGLIRNLSRNARNKD-EMSTKVVSHLIEKLPGSVGEKSPP------AEV------------ 732

  Fly   739 DWFLANIVCQALWNLLIDGHCAANLCQSSNIL--DEVSDLLADYLDEDRLSPGDDDNDNDEDDPE 801
               |.||:. .|.||::....||.     ::|  |.:..|:  ::.:.|.||       |.:...
Human   733 ---LVNIIA-VLNNLVVASPIAAR-----DLLYFDGLRKLI--FIKKKRDSP-------DSEKSS 779

  Fly   802 REAEDLDASDTDPEAHDALWE 822
            |.|..|.|:         ||:
Human   780 RAASSLLAN---------LWQ 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32668	NP_727502.1	armadillo repeat	571..611	CDD:293788	10/41 (24%)
		armadillo repeat	619..665	CDD:293788	11/47 (23%)
		armadillo repeat	670..708	CDD:293788	8/37 (22%)
PKP3	NP_001289958.1	ARM	336..447	CDD:237987	32/170 (19%)
		armadillo repeat	336..361	CDD:293788	4/27 (15%)
		armadillo repeat	369..405	CDD:293788	11/35 (31%)
		armadillo repeat	411..445	CDD:293788	12/90 (13%)
		ARM	412..550	CDD:237987	44/238 (18%)
		armadillo repeat	464..500	CDD:293788	11/41 (27%)
		armadillo repeat	508..549	CDD:293788	11/78 (14%)
		ARM	639..744	CDD:237987	31/136 (23%)
		armadillo repeat	663..697	CDD:293788	8/42 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900