DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32668 and pkp3b

DIOPT Version :9

Sequence 1:	NP_727502.1	Gene:	CG32668 / 318147	FlyBaseID:	FBgn0052668	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_002662884.1	Gene:	pkp3b / 100330353	ZFINID:	ZDB-GENE-130530-870	Length:	791	Species:	Danio rerio

Alignment Length:	924	Identity:	186/924 - (20%)
Similarity:	292/924 - (31%)	Gaps:	343/924 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AKQPADS--------DKSDRQQQLAKHHQMRHH-QPHASEQSLNKLGLVSSGTSGMGRRKT---- 74
            |.||..|        |...|:.||:|..:::.. |...:|:|.:...| ::.|...|...|
Zfish    14 ALQPNTSVTTYAIPTDDHRRRDQLSKVRRVQQQVQQRMAEKSTSSSRL-NASTEFNGHSPTVAYQ 77

  Fly    75 --SAELISEAKMFLGESVNAVPLLA-------------TGGARLVS--------TRRPIT----- 111
              |....|::.::.|....|||.|:             ||....:|        ..||.|
Zfish    78 TRSPGFSSKSMIYNGNRTMAVPRLSQYAGDFSSRSAVETGTRHRISLGVPMPAVVGRPYTYHDDA 142

  Fly   112 -------------PRESGRVLYGKVALAG----RPPSA---FSMRYLQNEKPSTPRQLPALSGSV 156
                         .|...|......|:||    |.||.   :...|.|:..|:|..:...|||::
Zfish   143 HLSSSYNQMQTSESRTLSRTEQEVAAMAGLTLQRQPSPVGNWMPNYGQSPSPNTAHRQRTLSGTL 207

  Fly   157 SATPMPT--RNGALLCQSSTETLIELLKQHSGLKDCSDETVQHIN--AILQELYTRVRKQERNYK 217
            :.....|  |..            ||..|:: .|..|..|:..||  .:.|:.:.|:......::
Zfish   208 AREGFNTGWREA------------ELANQYA-FKGPSHRTISRINNRQVQQQQHQRLSGSSMQWQ 259

  Fly   218 ---------------RGFI-----------------------------LGGLYGLVECTSPRVLL 238
                           :|.|                             |||::.|...|:...|
Zfish   260 QMSTGGNSLMGAGHYQGTIKRAGSVHSMKSVGRGVDVYDGLADGTADGLGGIHNLDMTTAVSYL- 323

  Fly   239 AVARVVLALRVTGSNLTGACKLIFKVARHEQHDALFHEHDVLELL-----IDGLGHASPLDEPEA 298
              :...:::::.|             |.:.||.. :|.::...::     |..|......:..|.
Zfish   324 --SSTDVSMQMLG-------------AAYVQHQC-YHSNEAKTMVRSLKGISALVQLFSSENQEV 372

  Fly   299 CIYAYGCIRFL--------TA-----------SSAQERDDALNRNWIGLETSGESQSLPIPALMP 344
            ..||.|..|.|        ||           .:.:|.||.|.:|..|:..:
Zfish   373 QRYATGATRNLIYENMDNKTALIEAGGISKLIGALREPDDELRKNITGILWN------------- 424

  Fly   345 PALSAISTSLCPRKLTGQQTLVSRLARHGAVELMILHLQMLNEAGATKRLQGPPLHTLYQLSAAM 409
                          |:.:.:|..||||....||             |:|:       |..||..
Zfish   425 --------------LSSKDSLKERLARESLAEL-------------TERV-------LVPLSGG- 454

  Fly   410 RALADVSQQQQRLQLQLQLACPHLIRAAEVSMGELEVQANV---VRTLSVLSEDSDCCETLHNYA 471
               .|....||                   |..|.::..|.   :|.||.::|     .|.....
Zfish   455 ---GDAGVIQQ-------------------SASEADIFFNTTGCLRNLSSVNE-----RTRQQMR 492

  Fly   472 ARIGLLLGPSCAGGGQWSERLLAVLSRLGYMLGNIL-AKHESARIQYFHNDVAMEYLLNVLEQLN 535
            ...||                  |.|.:||:..::. .|.|:..::   |.|.:  |.|:..||.
Zfish   493 ETRGL------------------VDSLVGYIQNSLQEGKGENKGVE---NCVCV--LRNLSYQLY 534

  Fly   536 ERSPSSVAHLDAQIKLIRVVANMSVNPEVGAGLGNVRSLGAVLLQLLSKTSEELTK----KKSPE 596
            ...||||     |::|...............|....:|..|      ...:::||.    .:.|:
Zfish   535 SEIPSSV-----QMRLEGPTRAQDTRHSDAIGCFTPQSKKA------KDRNQDLTTFTEVARVPK 588

  Fly   597 QQE-LLHATLGALHNLCFYQ-DKQAAVQPLAEGSLQSLI--DDLSAS-----------LAKVLGN 646
            ..| |.|..:.:|:|..... :...|.:..|.|:||::.  |...||           :..|:.:
Zfish   589 GAEWLWHPQIVSLYNQILQSCEANTATREAAAGALQNITAGDSRWASVLSRVALEQERMLPVILD 653

  Fly   647 CQTSVTKVELARVLGNLTRNEQARRCFCAAGGLPLMVQQLTKQAAGQDYELRTCAIGVLVNLL-G 710
            ...|.|..|| |.|..|.|| .:|.|               |..|    ::.|..:.||||.| .
Zfish   654 LLRSPTDAEL-RSLTGLLRN-LSRHC---------------KNKA----DMATKVVNVLVNKLPS 697

  Fly   711 DGEQRGPFLQLRGAELLSLLLRGSLEQEDWFLANIVCQALWNLLIDGHCAANLCQSSNILDEVSD 775
            ||.|:.|..::                    :.|| |..|.||:.....||   :.....|.:..
Zfish   698 DGHQKEPSSEV--------------------VVNI-CGVLNNLVTGSSLAA---RDITYFDGLPK 738

  Fly   776 LLADYLDEDRLSPG 789
            |::.....|. |||
Zfish   739 LVSIKSSHDN-SPG 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32668	NP_727502.1	armadillo repeat	571..611	CDD:293788	9/44 (20%)
		armadillo repeat	619..665	CDD:293788	16/58 (28%)
		armadillo repeat	670..708	CDD:293788	8/37 (22%)
pkp3b	XP_002662884.1	ARM	320..427	CDD:237987	23/150 (15%)
		armadillo repeat	349..385	CDD:293788	8/35 (23%)
		armadillo repeat	391..425	CDD:293788	8/60 (13%)
		armadillo repeat	446..480	CDD:293788	11/63 (17%)
		ARM	641..768	CDD:237987	38/157 (24%)
		armadillo repeat	641..673	CDD:293788	10/33 (30%)
		armadillo repeat	680..721	CDD:293788	17/65 (26%)
		armadillo repeat	727..766	CDD:293788	7/29 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900