DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mur11Da and Mmp1b

DIOPT Version :9

Sequence 1:	NP_727652.3	Gene:	Mur11Da / 318139	FlyBaseID:	FBgn0052644	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_114396.3	Gene:	Mmp1b / 83996	MGIID:	1933847	Length:	463	Species:	Mus musculus

Alignment Length:	166	Identity:	34/166 - (20%)
Similarity:	61/166 - (36%)	Gaps:	24/166 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PDPGNIPRYNQRPCGPRVCGKSGHCYRSFESICDFND-YNLKMI-FSGQELFELTEPIYCQPSPP 90
            |:|..:......||...:...:...||.  .:..|.| :.:::| |..:.|.::.:.|:  |:.|
Mouse   262 PNPIQLTDATLDPCNSGLTFDAIITYRG--EVIFFKDRFYIRVISFLPEPLIDVIDLIW--PNLP 322

  Fly    91 -------RTKLVDVGYYFNHRSLLVAQSQPSAYSSPIPRPSFTQNPKNIEHYDAYPSSDSYGPVQ 148
                   ....||...:|....:...|.|......|:...||...|.|:.:.||....:..|...
Mouse   323 GKFDAAYEVSGVDELRFFKGSKVWAVQEQNVLEGFPMDIQSFFGFPSNVTNIDAAVCEEETGKTY 387

  Fly   149 DYELPYPVWAF---KRPQAP--PR-----SPPVSYR 174
             :.:.:..|.:   .|...|  ||     .|.:.|:
Mouse   388 -FFVDHMYWRYDENTRSMDPGYPRLIAEDFPGIDYK 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mur11Da	NP_727652.3	None
Mmp1b	NP_114396.3	PG_binding_1	28..84	CDD:279773
		Cysteine switch. /evidence=ECO:0000250	87..94
		Metalloprotease. /evidence=ECO:0000250	95..273		2/10 (20%)
		Peptidase_M10	105..259	CDD:278824
		ZnMc_MMP	105..259	CDD:239805
		HX	273..463	CDD:238046	32/155 (21%)
		Hemopexin 1	278..321		9/46 (20%)
		Hemopexin 2	322..368		9/45 (20%)
		Hemopexin 3	371..419		9/48 (19%)
		Hemopexin 4	420..463		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900