DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mur11Da and MMP16

DIOPT Version :9

Sequence 1:	NP_727652.3	Gene:	Mur11Da / 318139	FlyBaseID:	FBgn0052644	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_005932.2	Gene:	MMP16 / 4325	HGNCID:	7162	Length:	607	Species:	Homo sapiens

Alignment Length:	210	Identity:	48/210 - (22%)
Similarity:	63/210 - (30%)	Gaps:	67/210 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LTALTLSQGHGDD-----------YLRFPDPGNIPRYNQRPCGPRVCGKSGHCYRSFESICDFND 64
            :|.:..|..|||.           :..||.||.....:.....|...|...|
Human   184 ITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNH------------- 235

  Fly    65 YNLKMIFSGQELFELTEPIYCQPSPPRTKLVDVGYYFNHRSLLVAQSQPSAYSSPIPRPSFTQNP 129
                   .|.:||                ||.| :...|...|...:.|:|..:|..:...|.|.
Human   236 -------DGNDLF----------------LVAV-HELGHALGLEHSNDPTAIMAPFYQYMETDNF 276

  Fly   130 KNIEHYDAYPSSDSYGPVQDYELPYPVWAFKRP--------QAPPRSPPVSYRPPYWYYPTRRPE 186
            | :.:.|.......|||..  ::|.|.    ||        ..||..|..:.||.....||.||.
Human   277 K-LPNDDLQGIQKIYGPPD--KIPPPT----RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPS 334

  Fly   187 I--TKP--CYGRTTT 197
            .  .||  |.|...|
Human   335 YPGAKPNICDGNFNT 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mur11Da	NP_727652.3	None
MMP16	NP_005932.2	PG_binding_1	42..96	CDD:366659
		Cysteine switch. /evidence=ECO:0000250	99..106
		Peptidase_M10	126..291	CDD:334067	27/144 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..340		17/64 (27%)
		PHA03247	<292..338	CDD:223021	14/51 (27%)
		HX	340..532	CDD:238046	4/10 (40%)
		Hemopexin 1	340..388		4/10 (40%)
		Hemopexin 2	389..434
		Hemopexin 3	436..484
		Hemopexin 4	485..532
		DUF3377	538..607	CDD:371766
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900