DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mur11Da and MMP15

DIOPT Version :9

Sequence 1:	NP_727652.3	Gene:	Mur11Da / 318139	FlyBaseID:	FBgn0052644	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_002419.1	Gene:	MMP15 / 4324	HGNCID:	7161	Length:	669	Species:	Homo sapiens

Alignment Length:	185	Identity:	47/185 - (25%)
Similarity:	63/185 - (34%)	Gaps:	45/185 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LTALTLSQGHGDDYLRFPDPGNIPRYNQRPCGPRVCGKSGHCYRSFESICDFNDYNLKMIFSGQE 75
            :..|..|..|||. ..|...|....:...| ||   |..|..:...:....|:..:|    .|..
Human   197 IMVLFASGFHGDS-SPFDGTGGFLAHAYFP-GP---GLGGDTHFDADEPWTFSSTDL----HGNN 252

  Fly    76 LFELTEPIYCQPSPPRTKLVDVGYYFNHRSLLVAQSQPSAYSSPIPRPSFTQNPKNIEHYDAYPS 140
            ||                ||.| :...|...|...|.|:|..:|     |.| .|::::: ..|.
Human   253 LF----------------LVAV-HELGHALGLEHSSNPNAIMAP-----FYQ-WKDVDNF-KLPE 293

  Fly   141 SDSYGPVQDY---------ELPYPVWAFKRPQAPPRSPPVSYRPPYWYYPTRRPE 186
            .|..|..|.|         ..|.|....:||..|...||   |||....|..:||
Human   294 DDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPP---RPPQPPPPGGKPE 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mur11Da	NP_727652.3	None
MMP15	NP_002419.1	PG_binding_1	53..106	CDD:279773
		Cysteine switch. /evidence=ECO:0000250	109..116
		Peptidase_M10	138..304	CDD:278824	33/139 (24%)
		ZnMc_MMP	138..304	CDD:239805	33/139 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..370		15/49 (31%)
		HX	367..559	CDD:238046
		Hemopexin 1	367..415
		Hemopexin 2	416..461
		Hemopexin 3	463..511
		Hemopexin 4	512..559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..593
		DUF3377	<644..669	CDD:288690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900