DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mur11Da and MMP14

DIOPT Version :9

Sequence 1:	NP_727652.3	Gene:	Mur11Da / 318139	FlyBaseID:	FBgn0052644	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_004986.1	Gene:	MMP14 / 4323	HGNCID:	7160	Length:	582	Species:	Homo sapiens

Alignment Length:	180	Identity:	45/180 - (25%)
Similarity:	62/180 - (34%)	Gaps:	42/180 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 HGDDYLRFPDPGNIPRYNQRPCGPRVCGKSGHCYRSFESICDFNDYNLKMIFSGQELFELTEPIY 84
            |||. ..|...|....:...| ||.:.|.:     .|:|...:...|..:  :|.::|
Human   186 HGDS-TPFDGEGGFLAHAYFP-GPNIGGDT-----HFDSAEPWTVRNEDL--NGNDIF------- 234

  Fly    85 CQPSPPRTKLVDVGYYFNHRSLLVAQSQPSAYSSPIPRPSFTQNPKNIEHYDAYPSSDSYGPVQD 149
                     ||.| :...|...|...|.|||..:|..:...|:|       ...|..|..|..|.
Human   235 ---------LVAV-HELGHALGLEHSSDPSAIMAPFYQWMDTEN-------FVLPDDDRRGIQQL 282

  Fly   150 Y--ELPYPVWAFKRPQAPPRSPPVSYRPPYWYYPTRRPEITKPCYGRTTT 197
            |  |..:|.....:|:...| |.|..:|.   .||..|.|   |.|...|
Human   283 YGGESGFPTKMPPQPRTTSR-PSVPDKPK---NPTYGPNI---CDGNFDT 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mur11Da	NP_727652.3	None
MMP14	NP_004986.1	PG_binding_1	36..88	CDD:279773
		Peptidase_M10	118..284	CDD:278824	30/130 (23%)
		ZnMc_MMP	118..284	CDD:239805	30/130 (23%)
		HX	316..508	CDD:238046	5/13 (38%)
		DUF3377	<560..582	CDD:288690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900