DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mur11Da and MMP13

DIOPT Version :9

Sequence 1:	NP_727652.3	Gene:	Mur11Da / 318139	FlyBaseID:	FBgn0052644	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_002418.1	Gene:	MMP13 / 4322	HGNCID:	7159	Length:	471	Species:	Homo sapiens

Alignment Length:	166	Identity:	37/166 - (22%)
Similarity:	48/166 - (28%)	Gaps:	66/166 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 HGDDYLRFPDPGNIPRYNQRPCGPRVCGKSGHCYRSFESICDFND----------YNLKMIFSGQ 74
            |||.| .|..|..:..: ..|.||.. |...|          |:|          |||.::
Human   172 HGDFY-PFDGPSGLLAH-AFPPGPNY-GGDAH----------FDDDETWTSSSKGYNLFLV---- 219

  Fly    75 ELFELTEPIYCQPSPPRTKLVDVGYYFNHRSLLVAQSQPSAYSSPIPRPSFTQNPKNIEHY---- 135
                                  ..:.|.|...|.....|.|...||    :|...|:  |:
Human   220 ----------------------AAHEFGHSLGLDHSKDPGALMFPI----YTYTGKS--HFMLPD 256

  Fly   136 -DAYPSSDSYGPVQDYELPYPVWAFKRPQAPPRSPP 170
             |.......|||..  |.|.|    |.|:.|.:..|
Human   257 DDVQGIQSLYGPGD--EDPNP----KHPKTPDKCDP 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mur11Da	NP_727652.3	None
MMP13	NP_002418.1	PG_binding_1	32..91	CDD:307564
		Cysteine switch. /evidence=ECO:0000250	94..101
		Peptidase_M10	112..267	CDD:306839	27/139 (19%)
		Interaction with TIMP2	176..246		20/112 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..284		9/26 (35%)
		Interaction with collagen	268..471		8/25 (32%)
		HX	281..471	CDD:238046	2/6 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900