DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mur11Da and MMP1

DIOPT Version :9

Sequence 1:	NP_727652.3	Gene:	Mur11Da / 318139	FlyBaseID:	FBgn0052644	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_002412.1	Gene:	MMP1 / 4312	HGNCID:	7155	Length:	469	Species:	Homo sapiens

Alignment Length:	204	Identity:	37/204 - (18%)
Similarity:	68/204 - (33%)	Gaps:	52/204 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RPCGPRVCGKSGHCYRSFESICDFNDYNLKMIFSGQELFELTEPIYCQPSPPRTKL--------- 94
            :|.||:. .|:.....:|::|.....   :::|.....:..|.|.|     |..:|
Human   268 QPIGPQT-PKACDSKLTFDAITTIRG---EVMFFKDRFYMRTNPFY-----PEVELNFISVFWPQ 323

  Fly    95 ----VDVGY---------YFNHRSLLVAQSQPSAYSSPIPRPSFTQNPKNIEHYDAYPSSDSYGP 146
                ::..|         :|........|.|...:..|....|....|:.::|.||..|.::.|.
Human   324 LPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGK 388

  Fly   147 VQDYELPYPVW---AFKRPQAPPRSPPVSYRPP----------------YWYYPTRRPEITKPCY 192
            .. :.:....|   .:||...|.....:::..|                |:::.||:.:. .|..
Human   389 TY-FFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKF-DPKT 451

  Fly   193 GRTTTATKA 201
            .|..|..||
Human   452 KRILTLQKA 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mur11Da	NP_727652.3	None
MMP1	NP_002412.1	PG_binding_1	27..87	CDD:396175
		Cysteine switch. /evidence=ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:2153297	90..97
		Metalloprotease	98..276		3/8 (38%)
		Peptidase_M10	108..261	CDD:395334
		HX	275..466	CDD:238046	34/196 (17%)
		Hemopexin 1	275..324		9/56 (16%)
		Hemopexin 2	325..371		6/45 (13%)
		Hemopexin 3	374..422		10/48 (21%)
		Hemopexin 4	423..466		8/39 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900