DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lim1 and Nanog

DIOPT Version :9

Sequence 1:	NP_572505.1	Gene:	Lim1 / 31813	FlyBaseID:	FBgn0026411	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_082292.1	Gene:	Nanog / 71950	MGIID:	1919200	Length:	305	Species:	Mus musculus

Alignment Length:	156	Identity:	30/156 - (19%)
Similarity:	62/156 - (39%)	Gaps:	27/156 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 LGLGVLGPNGPDSAGGPLGTSDIS------------------VQSMSTDSKNTHDDSDQGSLDGD 225
            :.:|:.||:...|:.....:.:.|                  .:.:.|::.:....|:...|.|.
Mouse     1 MSVGLPGPHSLPSSEEASNSGNASSMPAVFHPENYSCLQGSATEMLCTEAASPRPSSEDLPLQGS 65

  Fly   226 PDGRGDSQAENKSPDDANG---------SKRRGPRTTIKAKQLEVLKTAFNQTPKPTRHIREQLA 281
            ||.....:.:..||:...|         ::::..||.....||..||..|.:....:....::|:
Mouse    66 PDSSTSPKQKLSSPEADKGPEEEENKVLARKQKMRTVFSQAQLCALKDRFQKQKYLSLQQMQELS 130

  Fly   282 KETGLPMRVIQVWFQNKRSKERRMKQ 307
            ....|..:.::.||||:|.|.:|.::
Mouse   131 SILNLSYKQVKTWFQNQRMKCKRWQK 156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lim1	NP_572505.1	LIM1_Lhx1_Lhx5	27..78	CDD:188753
		LIM2_Lhx1_Lhx5	86..141	CDD:188761
		COG5576	185..324	CDD:227863	29/150 (19%)
		Homeobox	250..303	CDD:278475	15/52 (29%)
Nanog	NP_082292.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..95		9/48 (19%)
		Sufficient for interaction with SALL4. /evidence=ECO:0000269\|PubMed:16840789	96..155		16/58 (28%)
		HOX	96..152	CDD:197696	15/55 (27%)
		Required for DNA-binding. /evidence=ECO:0000250\|UniProtKB:Q9H9S0	123..152		8/28 (29%)
		10 X repeats starting with a Trp in each unit	198..247
		Sufficient for transactivation activity	198..247
		Sufficient for strong transactivation activity	248..305
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910