DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lim1 and Isl1

DIOPT Version :10

Sequence 1:NP_572505.1 Gene:Lim1 / 31813 FlyBaseID:FBgn0026411 Length:505 Species:Drosophila melanogaster
Sequence 2:NP_059035.3 Gene:Isl1 / 64444 RGDID:61957 Length:349 Species:Rattus norvegicus


Alignment Length:341 Identity:106/341 - (31%)
Similarity:154/341 - (45%) Gaps:87/341 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 VGDP---------CAGCNKPILDKFLLNV---LERAWHASCVRCCECLQPLTDK--CFSRESKLY 73
            :|||         |.||...|.|:::|.|   ||  |||:|::|.||.|.|.:.  ||.|:.|.|
  Rat     4 MGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLE--WHAACLKCAECNQYLDESCTCFVRDGKTY 66

  Fly    74 CRNDFFRRYGTKCSGCGQGIAPSDLVRKPRDKVFHLNCFTCCICRKQLSTGEQLYVLDDNKFICK 138
            |:.|:.|.||.||:.|..|.:.:|.|.:.|.||:|:.||.|..|.:||..|::..:.:|..| |:
  Rat    67 CKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLF-CR 130

  Fly   139 DDYLLGKAPSCGHNSLSDSLMGSASEDDDDDDPPHLRATALGLGVLGPNGP-DSAGGPLGTSDIS 202
            .|          |:.:..:.:|:.       ||         |..|.|..| ..|..|:.....:
  Rat   131 AD----------HDVVERASLGAG-------DP---------LSPLHPARPLQMAAEPISARQPA 169

  Fly   203 VQSMSTDSKNTHDDSDQGSLDGDPDGRGDSQAENKSPDDANGSKRRGPRTTIKAKQLEVLKTAFN 267
            ::      .:.|                      |.|:     |....||.:..|||..|:|.:.
  Rat   170 LR------PHVH----------------------KQPE-----KTTRVRTVLNEKQLHTLRTCYA 201

  Fly   268 QTPKPTRHIREQLAKETGLPMRVIQVWFQNKRSKERR----MKQITSMGRPPFFGGARKMRGFPM 328
            ..|:|...::|||.:.|||..|||:|||||||.|:::    |||:... :|......:.|.|.||
  Rat   202 ANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQQQ-QPNDKTNIQGMTGTPM 265

  Fly   329 -NLSP----GGLDDGP 339
             ..||    |||...|
  Rat   266 VAASPERHDGGLQANP 281

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lim1NP_572505.1 LIM1_Lhx1_Lhx5 27..78 CDD:188753 24/55 (44%)
LIM2_Lhx1_Lhx5 86..141 CDD:188761 19/54 (35%)
COG5576 185..324 CDD:227863 38/143 (27%)
Homeodomain 248..304 CDD:459649 26/55 (47%)
Isl1NP_059035.3 LIM1_Isl 17..71 CDD:188752 24/55 (44%)
LIM2_Isl 79..133 CDD:188760 20/64 (31%)
HOX 181..237 CDD:197696 26/55 (47%)
LIM-binding domain (LID). /evidence=ECO:0000250 262..291 9/20 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 312..349
Blue background indicates that the domain is not in the aligned region.

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