Protein Alignment Lim1 and LMX1A

DIOPT Version :10

• Sequence 1: NP_572505.1
• Gene: Lim1 / 31813
• FlyBaseID: FBgn0026411
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_796372.1
• Gene: LMX1A / 4009
• HGNCID: 6653
• Length: 382
• Species: Homo sapiens
• Alignment Length: 451
• Identity: 130/451 - (28%)
• Similarity: 185/451 - (41%)
• Gaps: 150/451 - (33%)

  Fly    14 IGRSEPPVGVGDPCAGCNKPILDKFLLNVLERAWHASCVRCCECLQPLTDKCFSRESKLYCRNDF 78
            :||:..|..|   |.||.:.|||:|||.:.:..||..||:|..|.:||...||.|:.||||:.|:
Human    25 LGRAVSPKSV---CEGCQRVILDRFLLRLNDSFWHEQCVQCASCKEPLETTCFYRDKKLYCKYDY 86

  Fly    79 FRRYGTKCSGCGQGIAPSDLVRKPRDKVFHLNCFTCCICRKQLSTGEQLYVLDDNKFICKDDYLL 143
            .:.:..||.||.:.|||::.|.:.:..|:||:||.||:|.:||..|:: :||.:.:.:||.||
Human    87 EKLFAVKCGGCFEAIAPNEFVMRAQKSVYHLSCFCCCVCERQLQKGDE-FVLKEGQLLCKGDY-- 148

  Fly   144 GKAPSCGHNSLSDSLMGSASEDDDDDDPPHLRATALGLGVLGPNGPDSAGGPLGTSDISVQSMST 208
                                |.:.:           .|.::.|...||     |.||
Human   149 --------------------EKERE-----------LLSLVSPAASDS-----GKSD-------- 169

  Fly   209 DSKNTHDDSDQGSLDGDPDGRGDSQAENKSPDDANGSKR-RGPRTTIKAKQLEVLKTAFNQTPKP 272
                     |:.||.....|.|...||     :....|| :.|||.:..:|....|.:|..:.||
Human   170 ---------DEESLCKSAHGAGKGTAE-----EGKDHKRPKRPRTILTTQQRRAFKASFEVSSKP 220

  Fly   273 TRHIREQLAKETGLPMRVIQVWFQNKRSK-----------------ERRMKQITSMGRPPFFGGA 320
            .|.:||.||.||||.:||:||||||:|:|                 .:|:....:.|     ||:
Human   221 CRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRQQQQQQDQQNTQRLSSAQTNG-----GGS 280

  Fly   321 RKMRGFPMNLSPGGLDDGPGFPY----------------FAADAKFEFGYGGPFHPHDGPYFPGH 369
            ..|.|. ||            ||                :::|         ||..
Human   281 AGMEGI-MN------------PYTALPTPQQLLAIEQSVYSSD---------PFRQ--------- 314

  Fly   370 PGGPMPFNAPGGPMDHSGPIPMVNEFGLTPEATFLGQAG---------GPPMQLQSAVGPP 421
              |..|...||..|...|..|:.::  |..:.|.|...|         ||   |||.||.|
Human   315 --GLTPPQMPGDHMHPYGAEPLFHD--LDSDDTSLSNLGDCFLATSEAGP---LQSRVGNP 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lim1	NP_572505.1	LIM1_Lhx1_Lhx5	27..78	CDD:188753	24/50 (48%)
		LIM2_Lhx1_Lhx5	86..141	CDD:188761	22/54 (41%)
		COG5576	185..324	CDD:227863	46/156 (29%)
		Homeodomain	248..304	CDD:459649	27/72 (38%)
LMX1A	NP_796372.1	LIM1_Lmx1a	35..86	CDD:188756	24/50 (48%)
		LIM2_Lmx1a_Lmx1b	94..148	CDD:188764	22/54 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..208		18/73 (25%)
		Homeodomain	196..252	CDD:459649	27/55 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	252..285		5/37 (14%)