DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lim1 and HOXC10

DIOPT Version :9

Sequence 1:	NP_572505.1	Gene:	Lim1 / 31813	FlyBaseID:	FBgn0026411	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_059105.2	Gene:	HOXC10 / 3226	HGNCID:	5122	Length:	342	Species:	Homo sapiens

Alignment Length:	187	Identity:	52/187 - (27%)
Similarity:	83/187 - (44%)	Gaps:	26/187 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 LGKAPSC-GHNSLSDSLMGSASEDDDDDDPPHLRATALGLGVLGPNGPDSAGGPLGTSDISVQSM 206
            |.|.|.| |.|.........||.:...:   ||.:..||..|..|..|.|.......::|..:..
Human   158 LDKTPHCSGANDFEAPFEQRASLNPRAE---HLESPQLGGKVSFPETPKSDSQTPSPNEIKTEQS 219

  Fly   207 STDSKNTHDDSDQ---GSLDGDPD-----GRGDSQAENKSPD---DANGSKRRGPRTTIKAKQLE 260
            ....|.:..:|::   .:.|..||     .:.:.:|||.:.:   ..:|.|:|.|.|  |.:.||
Human   220 LAGPKGSPSESEKERAKAADSSPDTSDNEAKEEIKAENTTGNWLTAKSGRKKRCPYT--KHQTLE 282

  Fly   261 VLKT-AFNQTPKPTRHIREQLAKETGLPMRVIQVWFQNKRSK------ERRMKQITS 310
            :.|. .||.  ..||..|.:::|...|..|.:::||||:|.|      |.|::::||
Human   283 LEKEFLFNM--YLTRERRLEISKTINLTDRQVKIWFQNRRMKLKKMNRENRIRELTS 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lim1	NP_572505.1	LIM1_Lhx1_Lhx5	27..78	CDD:188753
		LIM2_Lhx1_Lhx5	86..141	CDD:188761
		COG5576	185..324	CDD:227863	39/144 (27%)
		Homeobox	250..303	CDD:278475	20/59 (34%)
HOXC10	NP_059105.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..271		17/83 (20%)
		Homeobox	271..324	CDD:306543	21/56 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910