DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lim1 and lin-11

DIOPT Version :9

Sequence 1:	NP_572505.1	Gene:	Lim1 / 31813	FlyBaseID:	FBgn0026411	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_492696.1	Gene:	lin-11 / 172893	WormBaseID:	WBGene00003000	Length:	405	Species:	Caenorhabditis elegans

Alignment Length:	401	Identity:	154/401 - (38%)
Similarity:	204/401 - (50%)	Gaps:	96/401 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GDPCAGCNKPILDKFLLNVLERAWHASCVRCCECLQPLTDKCFSRESKLYCRNDFFRRYGTKCSG 88
            |:.||.|.:||||:::..||.:.||.||:|||:|..|::..||||:..:.|:.||.|||..:|:|
Worm    65 GNECAACAQPILDRYVFTVLGKCWHQSCLRCCDCRAPMSMTCFSRDGLILCKTDFSRRYSQRCAG 129

  Fly    89 CGQGIAPSDLVRKPRDKVFHLNCFTCCICRKQLSTGEQLYVLDDNKFICKDDYLLG---KAPSCG 150
            |...:...||||:.||||||:.||.|.:|::.|.||:|||:::.|:|:|:.|:...   ..|:..
Worm   130 CDGKLEKEDLVRRARDKVFHIRCFQCSVCQRLLDTGDQLYIMEGNRFVCQSDFQTATKTSTPTSI 194

  Fly   151 HNSLSDSLMGSASEDDDDDDPPHLRATALGLGVLGPNGPDSAGGPLGTSDISVQSMSTDSKNTHD 215
            |..:|:   ||....|.::|                                          ..|
Worm   195 HRPVSN---GSECNSDVEED------------------------------------------NVD 214

  Fly   216 DSDQGSLDGDPDGRGDSQAENKSPDDANGSKRRGPRTTIKAKQLEVLKTAFNQTPKPTRHIREQL 280
            ..|:..||   ||.||...:|.  ||:|.:|||||||||||||||.||.||..||||||||||||
Worm   215 ACDEVGLD---DGEGDCGKDNS--DDSNSAKRRGPRTTIKAKQLETLKNAFAATPKPTRHIREQL 274

  Fly   281 AKETGLPMRVIQVWFQNKRSKERRMKQITSMGRPPFFGGARKMRGFPMNLSPGGLDDGPGFPYFA 345
            |.||||.||||||||||:|||||||||:.       |||.|:.|. |..      ||       .
Worm   275 AAETGLNMRVIQVWFQNRRSKERRMKQLR-------FGGYRQSRR-PRR------DD-------I 318

  Fly   346 ADAKFEFGYGGPFHPHDGPYFPGHPGGPMPF------NAPGGP----MDHSGPIPMVNEFGLTPE 400
            .|          ..|:|..::|..|...:.|      .:|..|    |.....:|..| ..:.||
Worm   319 VD----------MFPNDQQFYPPPPPSNVQFFCDPYTTSPNNPETIQMAPQFAVPTEN-MNMVPE 372

  Fly   401 ATFLGQAGGPP 411
             .:..|:..||
Worm   373 -PYTEQSATPP 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lim1	NP_572505.1	LIM1_Lhx1_Lhx5	27..78	CDD:188753	23/50 (46%)
		LIM2_Lhx1_Lhx5	86..141	CDD:188761	26/54 (48%)
		COG5576	185..324	CDD:227863	71/138 (51%)
		Homeobox	250..303	CDD:278475	45/52 (87%)
lin-11	NP_492696.1	LIM	68..123	CDD:278823	26/54 (48%)
		LIM2_Lhx1_Lhx5	127..182	CDD:188761	26/54 (48%)
		Homeobox	244..297	CDD:278475	45/52 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165289
Domainoid	1	1.000	102	1.000	Domainoid score	I4325
eggNOG	1	0.900	-	-		E33208_3B9QY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	258	1.000	Inparanoid score	I1936
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002932
OrthoInspector	1	1.000	-	-		oto20817
orthoMCL	1	0.900	-	-		OOG6_105769
Panther	1	1.100	-	-	LDO	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2608
SonicParanoid	1	1.000	-	-		X1931
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780