DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0020 and KRE33

DIOPT Version :9

Sequence 1:	NP_572503.1	Gene:	l(1)G0020 / 31811	FlyBaseID:	FBgn0027330	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	NP_014267.1	Gene:	KRE33 / 855591	SGDID:	S000005076	Length:	1056	Species:	Saccharomyces cerevisiae

Alignment Length:	1070	Identity:	499/1070 - (46%)
Similarity:	691/1070 - (64%)	Gaps:	85/1070 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVKKKIDNRIRVMIENGVKLGHRTMFIVIGDKARDQVPILYDILTKSTVKARPTVLWCYKNKDEA 65
            |.||.||:||..:|.|||:...|::|:::||:||:|:|.|:.::..:.:|...:|||.||.|...
Yeast     1 MAKKAIDSRIPSLIRNGVQTKQRSIFVIVGDRARNQLPNLHYLMMSADLKMNKSVLWAYKKKLLG 65

  Fly    66 ISNHGKKR----AKKIAVGKVDVNEADLFDSFRVATTIHGRYYSETHAVLGRTYGVCVLQDFEAL 126
            .::|.|||    .|:|..|..:|||.|.|:||.....|...||.|:..:||.|||:|:|||||||
Yeast    66 FTSHRKKRENKIKKEIKRGTREVNEMDPFESFISNQNIRYVYYKESEKILGNTYGMCILQDFEAL 130

  Fly   127 TPNLLARTVETVEGGGLIILLLKTLQSLKQLYTMSMDVHKRFRTEAHQTVTCRFNERLILSLADC 191
            ||||||||:|||||||::::|||::.||||||||:||||.|:|||||..|..|||||.||||...
Yeast   131 TPNLLARTIETVEGGGIVVILLKSMSSLKQLYTMTMDVHARYRTEAHGDVVARFNERFILSLGSN 195

  Fly   192 KRCLVVNDDLTVLPLSSKTINVEPVNPAGAGR-SPNEASLKELKESLLTVQPAGALVNLCKTYDQ 255
            ..||||:|:|.|||||... ||:|:.|..... .|.:..|:||||||..|||||:||:|.||.:|
Yeast   196 PNCLVVDDELNVLPLSGAK-NVKPLPPKEDDELPPKQLELQELKESLEDVQPAGSLVSLSKTVNQ 259

  Fly   256 ANAVAQFIEALVDKQLKPPMSLTAARGRGKSAALGLSIAAAVAFGYVNIYVTSPHPENLITLFEF 320
            |:|:..||:|:.:|.|...::|||.||||||||||:||||||:.||.||:||||.||||.|||||
Yeast   260 AHAILSFIDAISEKTLNFTVALTAGRGRGKSAALGISIAAAVSHGYSNIFVTSPSPENLKTLFEF 324

  Fly   321 VLKGFDALEYQEHADYTIIRSTNADYKKAIIRINITRSSRQTIQYIAPSDTHLLNAADLLLIDEA 385
            :.||||||.||||.||.||:|||.|:.|||:|::|.|..|||||||.|.|..:|..|:|::||||
Yeast   325 IFKGFDALGYQEHIDYDIIQSTNPDFNKAIVRVDIKRDHRQTIQYIVPQDHQVLGQAELVVIDEA 389

  Fly   386 AAIPLPLVKKMIGPYLVFMASTINGYEGTGRSLSLKLISQLQKDNNAR----------------- 433
            ||||||:||.::||||||||||||||||||||||||||.||:..||..
Yeast   390 AAIPLPIVKNLLGPYLVFMASTINGYEGTGRSLSLKLIQQLRNQNNTSGRESTQTAVVSRDNKEK 454

  Fly   434 -----------PPLKLEESIRYQENDDIEKWLINLLCLDASTVPS---ISSGCPTPDACELYYVD 484
                       ..:.|:|.|||...|.|||||..|||||.:.:.:   .:.|.|.|..|.|:.|:
Yeast   455 DSHLHSQSRQLREISLDEPIRYAPGDPIEKWLNKLLCLDVTLIKNPRFATRGTPHPSQCNLFVVN 519

  Fly   485 RDALFSYHKAAEAFLHRLVSIYVSSHYKNTPNDLQMMSDAPAHHLFCLLGPVQRMDA--LPEILV 547
            ||.|||||..:|.||.:::::||||||||:|||||:|||||||.||.||.|:...|.  :|:.|.
Yeast   520 RDTLFSYHPVSENFLEKMMALYVSSHYKNSPNDLQLMSDAPAHKLFVLLPPIDPKDGGRIPDPLC 584

  Fly   548 VIQVALEGQISAQSISDSLGRGKKAAGDLIPWNVAEQYGDRDFPKLCGVRIVRVATHPNYQRMGY 612
            |||:||||:||.:|:.:||.||::|.||||||.:::|:.|.:|..|.|.||||:||:|.|..|||
Yeast   585 VIQIALEGEISKESVRNSLSRGQRAGGDLIPWLISQQFQDEEFASLSGARIVRIATNPEYASMGY 649

  Fly   613 GKRAIQLLKDYYARKHTNLEDGPVASKDAGKGIEEVEEEEL---SLLKEQIRPR--SRIPTLLQR 672
            |.|||:||:||:..|.|::.: .|..||  ..|:.|.::||   :|||:.::.|  ..:|.||.:
Yeast   650 GSRAIELLRDYFEGKFTDMSE-DVRPKD--YSIKRVSDKELAKTNLLKDDVKLRDAKTLPPLLLK 711

  Fly   673 LHERVPEHVDYIGTSYGLTTELLKFWKNAGFVPVYLSQKSNELTAEHSCIMLHT--PNATPWLGL 735
            |.|:.|.::.|:|.|||||..|.|||||..||||||.|.:|:||.||:|:||:.  ...:.||..
Yeast   712 LSEQPPHYLHYLGVSYGLTQSLHKFWKNNSFVPVYLRQTANDLTGEHTCVMLNVLEGRESNWLVE 776

  Fly   736 YYQDFRRRVLKLMGKTFREFETKLCLALLKNKS-----VDTEGSALKVLDKPMLDVYFLPHDLQR 795
            :.:|||:|.|.|:...|.:|.....|:::::..     .|.|....|.|.:..||..|.|.||:|
Yeast   777 FAKDFRKRFLSLLSYDFHKFTAVQALSVIESSKKAQDLSDDEKHDNKELTRTHLDDIFSPFDLKR 841

  Fly   796 LESYARQQSEFRLIIDLLTDIAQLYFQGRI-DGLQLDLVQQGILLALGVQGKTVDALGLELNMPG 859
            |:||:....::.:|.|::..:|.|||..:: |.::|..||..||||:|:|.|.:|.:..|||:|.
Yeast   842 LDSYSNNLLDYHVIGDMIPMLALLYFGDKMGDSVKLSSVQSAILLAIGLQRKNIDTIAKELNLPS 906

  Fly   860 NQLLAKFFDAMKRCNQCFRSVLEEHIEGGM-------LREADLSKGEELQPLTLS-----LDKEL 912
            ||.:|.|...|::.:|.||.:|.:.||..:       :.|.|   |||::....:     ::::|
Yeast   907 NQTIAMFAKIMRKMSQYFRQLLSQSIEETLPNIKDDAIAEMD---GEEIKNYNAAEALDQMEEDL 968

  Fly   913 DQTAQKLSKQQRKELKRL-KAEQLDEFQIKGTEEDWS---KALETNGTGGGSGLLSVKSGVKRLD 973
            ::...:..:..|::.|.| .:..||::.|....|:|:   |:||.  .....|::|:|:|.||
Yeast   969 EEAGSEAVQAMREKQKELINSLNLDKYAINDNSEEWAESQKSLEI--AAKAKGVVSLKTGKKR-- 1029

  Fly   974 GPIETREDGDLAAPLSKKKKKNNPKQRRSQ 1003
             ..|..||      :.:::.|...|.|:|:
Yeast  1030 -TTEKAED------IYRQEMKAMKKPRKSK 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0020	NP_572503.1	TmcA	21..882	CDD:224361	455/911 (50%)
		DUF1726	104..198	CDD:285542	64/93 (69%)
		Helicase_RecD	276..461	CDD:282921	128/212 (60%)
		GNAT_acetyltr_2	501..726	CDD:290437	120/231 (52%)
		tRNA_bind_2	744..863	CDD:290444	43/124 (35%)
KRE33	NP_014267.1	TmcA	20..930	CDD:224361	456/913 (50%)
		DUF1726	108..202	CDD:285542	64/93 (69%)
		SGNH_hydrolase	<165..>244	CDD:294667	43/79 (54%)
		Helicase_RecD	280..493	CDD:282921	128/212 (60%)
		GNAT_acetyltr_2	536..766	CDD:290437	120/232 (52%)
		tRNA_bind_2	785..910	CDD:290444	43/124 (35%)
		DLD	957..>996	CDD:291540	6/38 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343188
Domainoid	1	1.000	247	1.000	Domainoid score	I356
eggNOG	1	0.900	-	-		E1_COG1444
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6785
Inparanoid	1	1.050	876	1.000	Inparanoid score	I45
Isobase	1	0.950	-	0.919607	Normalized mean entropy	S369
OMA	1	1.010	-	-		QHG54077
OrthoFinder	1	1.000	-	-		FOG0003402
OrthoInspector	1	1.000	-	-		oto99060
orthoMCL	1	0.900	-	-		OOG6_101162
Panther	1	1.100	-	-	LDO	PTHR10925
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1773
SonicParanoid	1	1.000	-	-		X2298
TreeFam	1	0.960	-	-
	16	15.740