DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0020 and AT3G57940

DIOPT Version :9

Sequence 1:	NP_572503.1	Gene:	l(1)G0020 / 31811	FlyBaseID:	FBgn0027330	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	NP_191353.2	Gene:	AT3G57940 / 824963	AraportID:	AT3G57940	Length:	1028	Species:	Arabidopsis thaliana

Alignment Length:	1055	Identity:	461/1055 - (43%)
Similarity:	664/1055 - (62%)	Gaps:	88/1055 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VKKKIDNRIRVMIENGVKLGHRTMFIVIGDKARDQVPILYDILTKSTVKARPTVLWCYKNKDEAI 66
            ::||:|.|||.:|||||||.||:||::||||:|||:..|:.:|:|:.:|..|:||||||:|.: |
plant     1 MRKKVDERIRTLIENGVKLRHRSMFVIIGDKSRDQIVNLHHMLSKAVIKCNPSVLWCYKDKLD-I 64

  Fly    67 SNHGKKRAKKI----AVGKVDVNEADLFDSFRVATTIHGRYYSETHAVLGRTYGVCVLQDFEALT 127
            |:|.:||:|::    ..|::|..:.|.|........:....|.::..:||.|:|:|:||||||||
plant    65 SSHKQKRSKQLKRLRERGQLDPEKLDAFSRLLDVGRVTHCLYKDSERILGNTFGMCILQDFEALT 129

  Fly   128 PNLLARTVETVEGGGLIILLLKTLQSLKQLYTMSMDVHKRFRTEAHQTVTCRFNERLILSLADCK 192
            |||||||:||||||||::|:|::|.||..|.||.||||.|||||:|.....|||||.:||||.||
plant   130 PNLLARTIETVEGGGLVVLILRSLTSLTSLCTMVMDVHDRFRTESHSEAAGRFNERFLLSLASCK 194

  Fly   193 RCLVVNDDLTVLPLSS--KTINVEPVNPAGAGRSPNEASLKELKESLLTVQPAGALVNLCKTYDQ 255
            .|:|::|:|.:|||||  ::|...|......|.|..|..||.|||.|....|.|.|:..|.|.||
plant   195 ACVVMDDELNILPLSSHIRSITQVPTEKDSEGLSEAERDLKSLKEDLSDDFPVGPLIKKCCTLDQ 259

  Fly   256 ANAVAQFIEALVDKQLKPPMSLTAARGRGKSAALGLSIAAAVAFGYVNIYVTSPHPENLITLFEF 320
            ..||..|.:|::||.|:..::|.|:|||||||||||::|.|||.||.|||:|:|.|:||.|.|||
plant   260 GKAVVTFFDAILDKALRSIVALIASRGRGKSAALGLAVAGAVAAGYSNIYITAPSPDNLKTFFEF 324

  Fly   321 VLKGFDALEYQEHADYTIIRSTNADYKKAIIRINITRSSRQTIQYIAPSDTHLLNAADLLLIDEA 385
            |.||||||||:||.||.:::|.|.|:|||::||||.:..|||||||.|.:...|:..:||:||||
plant   325 VCKGFDALEYKEHLDYDVVKSANPDFKKAVVRINIFKQHRQTIQYIQPHEHEKLSQVELLVIDEA 389

  Fly   386 AAIPLPLVKKMIGPYLVFMASTINGYEGTGRSLSLKLISQLQKDNNARPP-------------LK 437
            ||||||:||.::||||||::||::|||||||||||||:.||  |..:|.|             ::
plant   390 AAIPLPVVKSLLGPYLVFLSSTVSGYEGTGRSLSLKLLQQL--DEQSRAPATGLEGSGCLFKKIE 452

  Fly   438 LEESIRYQENDDIEKWLINLLCLDAST-VPSISSGC-PTPDACELYYVDRDALFSYHKAAEAFLH 500
            |.|||||...|.||.||..|||||.:| :|  :..| |:|..|:||||:||.||||||.:|.||.
plant   453 LTESIRYGSGDPIESWLNGLLCLDVATCLP--NPACHPSPSQCDLYYVNRDTLFSYHKDSELFLQ 515

  Fly   501 RLVSIYVSSHYKNTPNDLQMMSDAPAHHLFCLLGPV-QRMDALPEILVVIQVALEGQISAQSISD 564
            |::::.|||||||:|||||:::||||||||.||||| :..:.:|:||.||||.|||:||..|...
plant   516 RMMALCVSSHYKNSPNDLQLLADAPAHHLFVLLGPVDESQNKIPDILCVIQVCLEGKISENSALQ 580

  Fly   565 SLGRGKKAAGDLIPWNVAEQYGDRDFPKLCGVRIVRVATHPNYQRMGYGKRAIQLLKDYY----- 624
            ||..|....||.|||...||:.|.:||...|.||||:|.|||..:||||..|::||..|:
plant   581 SLRDGHSPYGDQIPWKFCEQFRDTEFPGFSGARIVRIAVHPNAMKMGYGSAAVELLTRYFEGQIA 645

  Fly   625 ----ARKHTNLEDGPVASKDAGKGIEEVEEEELSLLKEQIRPRSRIPTLLQRLHERVPEHVDYIG 685
                |....::|..|:...:|.        |::|:|:||::||:.:|.||..||:|.||.:.|||
plant   646 PISEAEDKVDVEHAPIKVTEAA--------EKVSMLEEQVKPRTNLPPLLVPLHDRRPEKLHYIG 702

  Fly   686 TSYGLTTELLKFWKNAGFVPVYLSQKSNELTAEHSCIMLH-------TPNATPWLGL---YYQDF 740
            .|:|||.:|.:||:...|.|.|:||..:.:|.||:|::|.       ..|.:..||.   :|:||
plant   703 VSFGLTLDLFRFWRKHNFAPFYVSQIPSAVTGEHTCMLLKPLKNDELEVNESDELGFFTPFYKDF 767

  Fly   741 RRRVLKLMGKTFREFETKLCLALLKNK----SVDTEGSA----LKVLDKPMLDVYFLPHDLQRLE 797
            :.|..||:...|::.:.||.:::|..|    .||:.||:    ||.|:.     ...|:|::||.
plant   768 KIRFSKLLSDKFKKMDYKLAMSVLNPKINFAEVDSSGSSSGGFLKTLNG-----ILSPYDMERLR 827

  Fly   798 SYARQQSEFRLIIDLLTDIAQLYFQGRIDGLQLDLVQQGILLALGVQGKTVDALGLELNMPGNQL 862
            :|....::|.|:.|:...:|..||:.::. :.|..||..|||.||:|.....::..::.:...|:
plant   828 AYTENLTDFNLVYDICKTLAHQYFEEKLP-VSLSYVQASILLCLGLQETDFSSIERQMQLERGQI 891

  Fly   863 LAKFFDAMKRCNQCFRSVLEEHIEGGMLREADLSKGEELQPLTLSLDKELDQTAQKLSKQQRKE- 926
            .:......:...:....|..:.|:..:.|    .|..||....:|:|.::.:.|:::.:|.:||
plant   892 HSLLLKVARELYKYLNGVAGKEIKSALPR----LKERELTAHNVSVDDDIREGAKQVEEQMKKEK 952

  Fly   927 LKRLKAEQLDEFQIKGTEEDWSKALETNGTGGGSGLLSVKSGVKRLDGPIETREDGDLAAPLSKK 991
            ::.|...:|.::.| |.:|  ::||: :.....||::||||          |:.:.:.....|.|
plant   953 IEGLMDSELQQYVI-GDKE--AEALQ-HSKISSSGIISVKS----------TKSENENGFDKSTK 1003

  Fly   992 KKKNNPKQRRSQGKS 1006
            |:.:: |:..|..||
plant  1004 KRSSD-KRSSSSSKS 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0020	NP_572503.1	TmcA	21..882	CDD:224361	416/909 (46%)
		DUF1726	104..198	CDD:285542	60/93 (65%)
		Helicase_RecD	276..461	CDD:282921	117/197 (59%)
		GNAT_acetyltr_2	501..726	CDD:290437	108/241 (45%)
		tRNA_bind_2	744..863	CDD:290444	35/126 (28%)
AT3G57940	NP_191353.2	TmcA	20..912	CDD:224361	416/910 (46%)
		DUF1726	106..200	CDD:285542	60/93 (65%)
		Helicase_RecD	280..476	CDD:282921	117/197 (59%)
		GNAT_acetyltr_2	516..744	CDD:290437	108/235 (46%)
		tRNA_bind_2	771..886	CDD:290444	34/120 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	236	1.000	Domainoid score	I618
eggNOG	1	0.900	-	-		E1_COG1444
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6785
Inparanoid	1	1.050	837	1.000	Inparanoid score	I71
OMA	1	1.010	-	-		QHG54077
OrthoDB	1	1.010	-	-		D296129at2759
OrthoFinder	1	1.000	-	-		FOG0003402
OrthoInspector	1	1.000	-	-		otm2668
orthoMCL	1	0.900	-	-		OOG6_101162
Panther	1	1.100	-	-	O	PTHR10925
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2298
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840