DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0020 and nat10

DIOPT Version :9

Sequence 1:	NP_572503.1	Gene:	l(1)G0020 / 31811	FlyBaseID:	FBgn0027330	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	NP_001184159.1	Gene:	nat10 / 779537	XenbaseID:	XB-GENE-5858432	Length:	1022	Species:	Xenopus tropicalis

Alignment Length:	1041	Identity:	529/1041 - (50%)
Similarity:	722/1041 - (69%)	Gaps:	58/1041 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVKKKIDNRIRVMIENGVKLGHRTMFIVIGDKARDQVPILYDILTKSTVKARPTVLWCYKNKDEA 65
            |.:|||||||||:|||||...||:.|:|:||:.:|||.||:.:|:|:||:|||:|||||| |:..
Frog     1 MQRKKIDNRIRVLIENGVAQKHRSFFVVVGDQGKDQVVILHHMLSKATVRARPSVLWCYK-KELG 64

  Fly    66 ISNHGKKR----AKKIAVGKVDVNEADLFDSFRVATTIHGRYYSETHAVLGRTYGVCVLQDFEAL 126
            .|::.||:    .|:|..|.:::.|.|.|:.|..||.|...||:|||.:||.|||:|||||||||
Frog    65 FSSNRKKKMRKLQKRIKSGSLNIKEDDPFELFVAATNIRYCYYNETHKILGNTYGMCVLQDFEAL 129

  Fly   127 TPNLLARTVETVEGGGLIILLLKTLQSLKQLYTMSMDVHKRFRTEAHQTVTCRFNERLILSLADC 191
            ||||||||||||||||:::|||:|:.||||||||:||||.|:||||||.|..|||||.|||||.|
Frog   130 TPNLLARTVETVEGGGIVVLLLRTMSSLKQLYTMTMDVHSRYRTEAHQDVVVRFNERFILSLASC 194

  Fly   192 KRCLVVNDDLTVLPLSSKTINVEPVNPAG--AGRSPNEASLKELKESLLTVQPAGALVNLCKTYD 254
            |.|:|::|.|.:||:||...|::|:.|..  |..||.|..|:::|.||...||.|.||..|||.|
Frog   195 KTCMVIDDQLNILPISSHIANIKPIPPKAQDASLSPEEQELQDVKLSLQDTQPVGVLVENCKTLD 259

  Fly   255 QANAVAQFIEALVDKQLKPPMSLTAARGRGKSAALGLSIAAAVAFGYVNIYVTSPHPENLITLFE 319
            ||.||.:||||:.:|.|:..::|||||||||||||||:||.||||||.||:||||.|:||.||||
Frog   260 QAKAVLKFIEAVSEKTLRSTVTLTAARGRGKSAALGLAIAGAVAFGYSNIFVTSPSPDNLHTLFE 324

  Fly   320 FVLKGFDALEYQEHADYTIIRSTNADYKKAIIRINITRSSRQTIQYIAPSDTHLLNAADLLLIDE 384
            |:.||||:|:||||.||.||:|.|.:::||::|:|:.:..|||||||.|:|...|..|:|::|||
Frog   325 FIFKGFDSLQYQEHMDYEIIQSLNPEFEKAVVRVNVFKEHRQTIQYIHPADAVKLGQAELVVIDE 389

  Fly   385 AAAIPLPLVKKMIGPYLVFMASTINGYEGTGRSLSLKLISQLQKDN------------------- 430
            ||||||||||.::||||||||||||||||||||||||||.||::.:
Frog   390 AAAIPLPLVKNLMGPYLVFMASTINGYEGTGRSLSLKLIQQLRQQSADSQVTVTAENKSTASNRL 454

  Fly   431 -NARP--PLKLEESIRYQENDDIEKWLINLLCLDASTVPSISSGCPTPDACELYYVDRDALFSYH 492
             :||.  .:.|:|||||...|.:||||.::||||...:..|.||||.|:.|:|||::||.||.||
Frog   455 ASARTLHEVTLQESIRYAPGDPVEKWLNDMLCLDCMNISRIISGCPLPETCDLYYINRDTLFCYH 519

  Fly   493 KAAEAFLHRLVSIYVSSHYKNTPNDLQMMSDAPAHHLFCLLGPV-QRMDALPEILVVIQVALEGQ 556
            ||:|:||.||:::||:|||||:|||||||||||||||||||.|| ...:::||:|.|:||.|||:
Frog   520 KASESFLQRLMALYVASHYKNSPNDLQMMSDAPAHHLFCLLPPVPPTQNSVPEVLAVVQVCLEGE 584

  Fly   557 ISAQSISDSLGRGKKAAGDLIPWNVAEQYGDRDFPKLCGVRIVRVATHPNYQRMGYGKRAIQLLK 621
            ||.|||..||.|||||:||||||.|:||:.|.||..|.|.|:||:|.||:||.||||.||::|::
Frog   585 ISRQSILSSLSRGKKASGDLIPWTVSEQFQDPDFGSLSGGRVVRIAVHPDYQGMGYGSRALRLVQ 649

  Fly   622 DYYARKHTNLEDGPVASKDAGKGIEEVEEEELSLLKEQIRPRSRIPTLLQRLHERVPEHVDYIGT 686
            .||..:...||:.   :.:..:.|..|..|.:|||:|.:.||..:|.||.||.||..|.:||:|.
Frog   650 MYYEGQFPCLEEN---ATNKPQEITSVSSEAVSLLEESLTPRKNLPPLLLRLSERPAEKLDYLGV 711

  Fly   687 SYGLTTELLKFWKNAGFVPVYLSQKSNELTAEHSCIMLHT------PNATPWLGLYYQDFRRRVL 745
            |||||.:||||||.||||||||.|..|:||.||||:||.|      .:..|||..:::|||:|.|
Frog   712 SYGLTPKLLKFWKRAGFVPVYLRQTPNDLTGEHSCVMLKTLHEDEESDQEPWLTAFWKDFRKRFL 776

  Fly   746 KLMGKTFREFETKLCLALLKNKSVDTEGSALKVLDKPMLDVYFLPHDLQRLESYARQQSEFRLII 810
            .|:...|..|...|.|.:|:|:::..|...|  :.:..|:....|:||:|||.|:|...::.||:
Frog   777 SLLSYQFSTFAPSLALNILQNRNIKKESENL--ISRSELEAGLTPYDLKRLEMYSRNMVDYHLIM 839

  Fly   811 DLLTDIAQLYFQGRIDGLQLDLVQQGILLALGVQGKTVDALGLELNMPGNQLLAKFFDAMKRCNQ 875
            ||:..:|::||..::.||.|...|..:||.:|:|.|:||.|..|:.:|.:||:..|...:::..|
Frog   840 DLIPSLARMYFLQQLGGLSLSAAQSALLLGIGLQHKSVDQLEKEIELPSSQLMGLFNRIIRKIVQ 904

  Fly   876 CFRSVLEEHIEGGMLREADLSKGEELQPLTLSLDKELDQTAQKLSKQQRKELKRLKAEQLDEFQI 940
            .|..:.|..:|    .|...:|...::|...||.::|::..::..::.::|:::||...|.|:.|
Frog   905 LFNRIQERAVE----EEMATTKEVVMEPTLKSLQEDLEEAGKEFQEKHKQEVEKLKGINLSEYVI 965

  Fly   941 KGTEEDWSKALETNGTGGGSGLLSVKSGVKR-LDGPIETREDGDLAAPLSKKKKKNNPKQRRSQG 1004
            :|.:|:|::.|:.  ||..:.::|:||..|| |:.|   .::|       .|:|||..|.:..:.
Frog   966 RGDDEEWNEVLKK--TGQNASVISMKSDKKRKLEQP---EKEG-------FKQKKNLKKNKEKKQ 1018

  Fly  1005 K 1005
            |
Frog  1019 K 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0020	NP_572503.1	TmcA	21..882	CDD:224361	480/895 (54%)
		DUF1726	104..198	CDD:285542	72/93 (77%)
		Helicase_RecD	276..461	CDD:282921	124/206 (60%)
		GNAT_acetyltr_2	501..726	CDD:290437	133/225 (59%)
		tRNA_bind_2	744..863	CDD:290444	41/118 (35%)
nat10	NP_001184159.1	TmcA	21..909	CDD:224361	480/893 (54%)
nat10	NP_001184159.1	Lipocalin	<877..956	CDD:389791	19/82 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	1.000	Domainoid score	I1819
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6785
Inparanoid	1	1.050	1010	1.000	Inparanoid score	I293
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D186208at33208
OrthoFinder	1	1.000	-	-		FOG0003402
OrthoInspector	1	1.000	-	-		oto102474
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1773
SonicParanoid	1	1.000	-	-		X2298
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090