DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)G0020 and nath-10

DIOPT Version :9

Sequence 1:	NP_572503.1	Gene:	l(1)G0020 / 31811	FlyBaseID:	FBgn0027330	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	NP_491574.1	Gene:	nath-10 / 172182	WormBaseID:	WBGene00018866	Length:	1043	Species:	Caenorhabditis elegans

Alignment Length:	1053	Identity:	500/1053 - (47%)
Similarity:	702/1053 - (66%)	Gaps:	63/1053 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VKKKIDNRIRVMIENGVKLGHRTMFIVIGDKARDQVPILYDILTKSTVKARPTVLWCYKNKDEAI 66
            ::.|:|.|||..|||||..|||:||.|:||||||||||||.||:||||.|||.|||||| |:.:.
Worm     1 MRTKLDGRIRTQIENGVASGHRSMFAVVGDKARDQVPILYHILSKSTVSARPNVLWCYK-KELSF 64

  Fly    67 SNHGKKRAKKIAVGKVDVN----EADLFDSFRVATTIHGRYYSETHAVLGRTYGVCVLQDFEALT 127
            |.|..|:|||:......::    :||.||.|..:|.|...||:||..:||.|:||.|||||||:|
Worm    65 STHRAKKAKKMKKATTTISGSLPDADPFDVFISSTQIRYCYYNETEKILGNTFGVLVLQDFEAMT 129

  Fly   128 PNLLARTVETVEGGGLIILLLKTLQSLKQLYTMSMDVHKRFRTEAHQTVTCRFNERLILSLADCK 192
            |||||||:||:||||::|||:::::||:||||:|||||.|:|||||..:|.|||||.|||||.|.
Worm   130 PNLLARTIETIEGGGMVILLMQSVRSLRQLYTISMDVHNRYRTEAHNEITARFNERFILSLASCS 194

  Fly   193 RCLVVNDDLTVLPLSSKTINVEPVNPAGAGR--SPNEASLKELKESLLTVQPAGALVNLCKTYDQ 255
            ..||::|.|.|||:||...|||.: ||...:  |.::|.|..|||::...:|.|.|::..:|..|
Worm   195 SVLVLDDQLRVLPISSHIENVEAI-PASQKKIQSESDAELASLKEAMKETKPIGPLLSRARTACQ 258

  Fly   256 ANAVAQFIEALVDKQLKPPMSLTAARGRGKSAALGLSIAAAVAFGYVNIYVTSPHPENLITLFEF 320
            |.|:.:|::.:.:||.....||||.||||||||:|||:|.|:||||.||:||||.||||.|||||
Worm   259 AKALLRFLDVITEKQSNVTCSLTAGRGRGKSAAVGLSLAGAIAFGYTNIFVTSPSPENLKTLFEF 323

  Fly   321 VLKGFDALEYQEHADYTIIRSTNADYKKAIIRINITRSSRQTIQYIAPSDTHLLNAADLLLIDEA 385
            |:||||||:||||.||.:|:|.|.::|..::|||:.|..:||||||:|:|...|...:|::||||
Worm   324 VVKGFDALDYQEHTDYELIQSANPEFKNCLVRINVFREHKQTIQYISPTDVQKLGQCELIVIDEA 388

  Fly   386 AAIPLPLVKKMI-GPYLVFMASTINGYEGTGRSLSLKLISQLQK-------------DNNARP-- 434
            |||||||||::| |||:.|::|||||||||||||||||:.||::             .|..:.
Worm   389 AAIPLPLVKELISGPYISFLSSTINGYEGTGRSLSLKLLQQLRQQSAGGEAKEGKSASNKGKTLH 453

  Fly   435 PLKLEESIRYQENDDIEKWLINLLCLDASTVP-SISSGCPTPDACELYYVDRDALFSYHKAAEAF 498
            .:.:||||||:..|.|||||..||||||:... .:..|.|.|.|||||.|:||.|||:|.|:|||
Worm   454 EMHMEESIRYKPGDKIEKWLNRLLCLDATNCQLKLECGTPPPAACELYIVNRDTLFSFHDASEAF 518

  Fly   499 LHRLVSIYVSSHYKNTPNDLQMMSDAPAHHLFCLLGPVQR-MDALPEILVVIQVALEGQISAQSI 562
            |.::::|:||:||||:||||||:||||||:||.|:.|:.: ...:||:|.|:||.|||::.:.:|
Worm   519 LQQVMAIFVSAHYKNSPNDLQMLSDAPAHNLFVLMAPIDKSRKTIPEVLAVVQVCLEGRLDSDNI 583

  Fly   563 SDSLGRGKKAAGDLIPWNVAEQYGDRDFPKLCGVRIVRVATHPNYQRMGYGKRAIQLLKDYYARK 627
            .:.|..||:|||||:||.|::|:.|:.|..|||.||||||.||:||.||||.||:||::.||...
Worm   584 QNGLESGKRAAGDLLPWTVSQQFMDKQFGTLCGGRIVRVAVHPDYQSMGYGGRAVQLIEQYYLGL 648

  Fly   628 HTNLEDGPVASKDAGKG-IEEVEE-EELSLLKEQIRPRSRIPTLLQRLHERVPEHVDYIGTSYGL 690
            .|:|::...|.....|. |::|:: ..:.||:|:|.||:.:|.|||||.||.||.:||:|.|:||
Worm   649 ATSLDEEEKAPAPPSKTVIKQVKDGHTVELLEERIEPRADLPPLLQRLDERKPERLDYLGVSFGL 713

  Fly   691 TTELLKFWKNAGFVPVYLSQKSNELTAEHSCIML-----------HTPNATPWLGLYYQDFRRRV 744
            |..||||||...|||||:.|.||::|.||:||:|           ..|:|| ||.:|:::||||:
Worm   714 TVPLLKFWKRNEFVPVYIRQNSNDITGEHTCIILKGLEHGGSDSDEEPSAT-WLPVYWREFRRRI 777

  Fly   745 LKLMGKTFREFETKLCLAL--LKNKSVDTEGSALKVLDKPMLDVYFLPHDLQRLESYARQQSEFR 807
            :.|:...|..|..::.|:|  ||||.|:.:...| |:::..|.::....||:|:..|.|...:..
Worm   778 VNLLSFDFSSFPAQMALSLLQLKNKHVEKQMKRL-VIERSELAIHLSNTDLRRMSQYGRNMVDSH 841

  Fly   808 LIIDLLTDIAQLYFQGRI-DGLQLDLVQQGILLALGVQGKTVDALGLELNMPGNQLLAKFFDAMK 871
            :|.|:|..:|:|.|:.|: ..|:|.:.|..||||.|:|.|..:.:..||::|.||:.|....|::
Worm   842 IITDILPIVAKLNFEQRLPQELKLAVTQSAILLARGLQHKHFEDISKELDLPMNQIFALLTKAIR 906

  Fly   872 RCNQCFRSVLEEHIEGGMLREADLSKGE-------ELQPLTLSLDKELDQTAQKLSKQQRKELKR 929
            |....|..|.|..:...:.:||:.|...       :..||. :|:.||:..|:::..:..::.|.
Worm   907 RIGDWFDEVCETAVRENLDKEAEASAANKPTSSLPKAVPLA-NLEDELESAAKEIRARHDRDRKA 970

  Fly   930 LKAE---QLDEFQIKGTEEDWSKALETNGTGGGSGLLSVKSGVKRLDGPIETREDGDLAAPLSKK 991
            |.||   :|.:::|...|::.::|.|:......:.|:||||....:...|...:|     |.:|.
Worm   971 LLAELGNELQKYEIIQDEKELAEAYESVNMKYANKLVSVKSKRTAIQAAIPDAKD-----PANKN 1030

  Fly   992 KKKNNPKQRRSQG 1004
            .||   |:|.|.|
Worm  1031 AKK---KKRFSSG 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0020	NP_572503.1	TmcA	21..882	CDD:224361	456/900 (51%)
		DUF1726	104..198	CDD:285542	63/93 (68%)
		Helicase_RecD	276..461	CDD:282921	120/200 (60%)
		GNAT_acetyltr_2	501..726	CDD:290437	119/238 (50%)
		tRNA_bind_2	744..863	CDD:290444	40/121 (33%)
nath-10	NP_491574.1	TmcA	20..914	CDD:224361	455/897 (51%)
		DUF1726	106..200	CDD:285542	63/93 (68%)
		Helicase_RecD	279..480	CDD:282921	120/200 (60%)
		GNAT_acetyltr_2	521..750	CDD:290437	119/228 (52%)
		tRNA_bind_2	780..897	CDD:290444	39/117 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158527
Domainoid	1	1.000	249	1.000	Domainoid score	I1168
eggNOG	1	0.900	-	-		E1_COG1444
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6785
Inparanoid	1	1.050	905	1.000	Inparanoid score	I188
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54077
OrthoDB	1	1.010	-	-		D186208at33208
OrthoFinder	1	1.000	-	-		FOG0003402
OrthoInspector	1	1.000	-	-		oto20376
orthoMCL	1	0.900	-	-		OOG6_101162
Panther	1	1.100	-	-	LDO	PTHR10925
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1773
SonicParanoid	1	1.000	-	-		X2298
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800