DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drd and CG5892

DIOPT Version :9

Sequence 1:	NP_001033845.1	Gene:	drd / 318102	FlyBaseID:	FBgn0260006	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_650959.2	Gene:	CG5892 / 42522	FlyBaseID:	FBgn0038873	Length:	738	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	199/783 - (25%)
Similarity:	324/783 - (41%)	Gaps:	124/783 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 FEDKVNYSLKLFADDATTTILEYQTAN----LSQLHAVTPGNYTIHQMEQAEDDDDQVEEDERAY 127
            |..::|...:|.|.|       ||..|    ||:.......|.|:         ||.|.|
  Fly    21 FGPEINEGNELDAQD-------YQRLNKVRHLSEQFFSYYKNVTL---------DDLVPE----- 64

  Fly   128 LYNIGKRFLAITQPFDAARNPDASTL-CRRQMHQFLNALDNFDLWALKMHDSSGKLNSGILNGNI 191
                             .|.|..|.| |.....|....|.:..|||.:|.||.|.:.||||.|::
  Fly    65 -----------------GRLPTVSDLQCYADFAQLTAGLASGSLWAYRMIDSWGSIPSGILKGHL 112

  Fly   192 NQPGDFDQCLGIQQRMNQDQDAGQDQDGDSIIRGQYCLAYAQPVLPHNSKRLKSFFKLIQSHGPF 256
            ...|.:|:|:.|:          |.....|.:.|:||||    .||           |.|..|
  Fly   113 KDLGHYDECIAIE----------QSAASGSTLLGKYCLA----SLP-----------LQQLLG-- 150

  Fly   257 KSEFNDPGHRVPRYSLINWGLCVPSGCSARDVEYSVAEYLGNQTASTGITFNVR-VEPQMCQVRD 320
                     .|.|...:...:|.|:.|||.:::..:...| .|.....:..|.. |....|:..:
  Fly   151 ---------NVGRMMNVQTAVCFPASCSATNMDTLLRRVL-KQLVGLELNSNQNLVSENSCKTSE 205

  Fly   321 QRPWDRNTTWAVRFFLLVLSV----AVLSTIYDR-STKSQPKQNPWFTAFSLDKNLRWLF--STS 378
            :..:|.....|:    ::|||    .::||.||. ....|.|.......||...|.|.||  :|.
  Fly   206 RDAYDGGAIAAI----VILSVFGGAVIISTFYDYFLCADQNKLPAILKVFSARANSRSLFRITTK 266

  Fly   379 SAPGDIEAVHGIRFLNAIMLIFSHKSMAMFFNPYNNRTAMSESLGQPWTVIGRAASLYTDPFLLF 443
            ..|..||.:||:|.::.|.:.|.|..:....:|..|...:......|:..|.:......|.|...
  Fly   267 PNPNVIECLHGLRGMSLIWVCFGHDFIISMTSPNINLYDVYTWAKTPFKDIIQEGVFAVDSFFFI 331

  Fly   444 SGMLTSYSLFGRLMKQQ-PIRLKNEYISRLMRIVPPLAALILFCTYVLPLWGSGP---QWNLVVG 504
            ||:|.:......:.|.: .:.:...|:.|.:|:.|.:|..||....:||..|.||   .||.
  Fly   332 SGLLVAMVALRSMEKAKGKLNIPLMYLHRYLRLTPIVAVSILLYWKLLPHLGDGPLYGNWNF--- 393

  Fly   505 HHADICKKNWWRNLLFIHNYFGFSEMCLTHTHHLGIDTELFAVAPLLILALWRWPRRGLFALLLL 569
            ...|.|:.||:..||::.||...|| ||.||.:|.|||:|:.:||:|::.:::|.::|. |::||
  Fly   394 DSYDRCEGNWYWTLLYVQNYATDSE-CLAHTWYLAIDTQLYIIAPILLIIVYKWGKKGA-AVVLL 456

  Fly   570 CTVGTAARYYTTIVNQLSNYIYF------GTNIQRLFRTADY---MYSFPPHRSTVYIMGILLGY 625
            ..:|..|..::.||  ::||...      |.:        ||   :..:..:|::.:::|.|.||
  Fly   457 LLLGLTAYLFSIIV--INNYSLISGGGGGGPD--------DYSEDLDHYTHNRASGWLVGFLFGY 511

  Fly   626 VLRKYQN--ARLSSLQLRLGWLVATVCVLASLLGPAPMG-DINYVYNSTHAAIYAAFAPIAWCLF 687
            .|...:.  .:||...:.:||:.....:...:....|.| ..:....:.:.|.|.:.:.|||.|.
  Fly   512 FLHTIRGKAIKLSRPAVWIGWITCLAFLFTCIFAMYPYGTGKSKTLPTLNEAFYVSLSRIAWPLG 576

  Fly   688 FSWIVFVSHNGYTNKLTKLFAWRGFQVSTKLSYAIYLTQFPVFFFNVGRRRHIHHYYNFVSIILD 752
            .||:||....||............:|..:|||:..|:....:...|.||.|...::.|:..::..
  Fly   577 LSWVVFACMQGYGGLANSFLTSPLWQPLSKLSFCAYMGHLFIQNLNAGRTRVNTYFSNYDIMLRF 641

  Fly   753 TNEFISIFLASVALTVLFDAPFQNLKKLLIKRPTAAKVVKDSKAKAAESQDATTTTLASQ-PSST 816
            ..:|....|.:..:.:|.:||...|:.|::.....|...|...|:.::.:..:...|..| |.|:
  Fly   642 WQDFGFTVLLAYVMYILIEAPCGGLESLILPNRRPAPQPKVQAAEPSKEEIPSPVDLEKQTPESS 706

  Fly   817 ALL 819
            |.:
  Fly   707 AAI 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drd	NP_001033845.1	NRF	169..>289	CDD:214781	35/119 (29%)
		OafA	371..791	CDD:224748	115/437 (26%)
		Acyl_transf_3	384..770	CDD:280013	104/401 (26%)
CG5892	NP_650959.2	NRF	90..203	CDD:214781	40/149 (27%)
		Acyl_transf_3	272..656	CDD:280013	104/398 (26%)
		OafA	277..685	CDD:224748	108/422 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.020