DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drd and CG42329

DIOPT Version :9

Sequence 1:	NP_001033845.1	Gene:	drd / 318102	FlyBaseID:	FBgn0260006	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_608590.2	Gene:	CG42329 / 33312	FlyBaseID:	FBgn0259229	Length:	691	Species:	Drosophila melanogaster

Alignment Length:	767	Identity:	190/767 - (24%)
Similarity:	338/767 - (44%)	Gaps:	143/767 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 TTILEYQTANLSQLHAVTPGNYTIHQMEQAEDDDDQVEEDERAYLYNIGKRFLAITQPFDAARNP 148
            ||...|.:.:|  |..:...|:....::||.:|:                      |...||
  Fly    15 TTAQTYSSKDL--LTWMQSSNFGYQVLQQALNDN----------------------QSSSAA--- 52

  Fly   149 DASTLCRRQMHQFLNALDNFDLWALKMHDSSGKLNSGILNGNINQPGDFDQCLGIQQRMNQDQ-- 211
            :||  |..::...|...:...|.||::.|:.||...|:|.|:....|:::.||.:....:...
  Fly    53 EAS--CLAEVRLLLTGAEAKSLPALRVFDAWGKFPQGLLYGHFMDMGNYESCLSLDLSKSLGNVM 115

  Fly   212 --DAGQDQDGDSIIRGQYCLAYAQPVLPHNSKRLKSFFKLIQSHGPFKSEFNDPGHRVPRYSLIN 274
              :||          .:|||:           |::....|:::.|             .....::
  Fly   116 TINAG----------AKYCLS-----------RMQFESLLMEAAG-------------ADALTLS 146

  Fly   275 WGLCVPSGCSARDVEYSVAEYL-----GNQTASTGITFNVRVEPQMCQVRDQRPWDRNTTWAVRF 334
            .|.|:||.|||..:...::.:|     .|.|.:|      .|:.:.|.:..:.|.:.....||..
  Fly   147 IGTCIPSSCSAAQLSRWMSGHLKDMFGQNSTEAT------LVQEKDCSLAHRDPMNGLDWLAVSI 205

  Fly   335 FLLVLSVAVLSTIYDRSTKSQPKQNPWFTAFSLDKNLRWLFSTSSAPGD--IEAVHGIRFLNAIM 397
            .:|:..|.:|:||.|.|..|    |...::|||.||:..|..||:.|..  |..::|||.|..|.
  Fly   206 LILLCIVVLLATILDYSCVS----NKLLSSFSLRKNVPQLLKTSNTPSPRVIPCLNGIRCLTIIW 266

  Fly   398 LIFSHKSMAMFFNPYNNRTAMSESLGQPWTVIGRAASLYTDPFLLFSGMLTSYSLF-------GR 455
            :|..|..|.:...|..|...:......|:::|.::.:...|.|.|.||:|...|..       ||
  Fly   267 IILGHGYMYLLLAPTINAYDIVAWAQMPFSMILQSGTTSVDTFFLLSGLLLVLSALREMDRSKGR 331

  Fly   456 LMKQQPIRLKNEYISRLMRIVPPLAALILFCTYVLPLWGSGPQWNLVVGHHADICKKNWWRNLLF 520
            |  ..|:.    |:.||:|:.|.||..:|....:.|...|||.||.... .:::|...||..||:
  Fly   332 L--HVPLM----YLHRLVRLTPVLALAVLIFMTLFPRLDSGPLWNQFTS-SSELCSDTWWATLLY 389

  Fly   521 IHNYFGFSEMCLTHTHHLGIDTELFAVAPLLILALWRWPRRGLFALLLLCTVGTAARYYTTIVNQ 585
            :.||.....|||.|:.:|.:|.:|:.::|||::||::|.::.:..::||..:.:...:...::..
  Fly   390 VQNYAAPGRMCLGHSWYLAVDMQLYIISPLLLIALYKWGKKAIAGIVLLILLLSGCVFGIVMLRD 454

  Fly   586 LSNYIYFG------TNIQRLFRTADYMYSFPPH-RSTVYIMGILLGYVLRKYQNARLSSLQLRLG 643
            |..:..:|      |.::.::.|.        | |:|.:::|:|.||.|. :||.|.:.|.   .
  Fly   455 LKVFDRYGNLGGDSTEMRLIYYTT--------HARATPWLIGLLFGYFLH-HQNVRKTRLP---K 507

  Fly   644 WLVATVCVLA-SLLG----------PAPMGDINYVYNSTHAAIYAAFAPIAWCLFFSWIVFVSHN 697
            ||...:.:|: |:|.          .:..|||    ::...|.|...:.|||.|...||::...|
  Fly   508 WLALVLWILSLSMLATVIFAVYPYTQSGAGDI----SAMAGAFYLCCSRIAWPLALCWIIWACQN 568

  Fly   698 GYTNKLTKLFAWRGFQVSTKLSYAIYLTQFPVFFFNVGRRRHIHHYYNFVSIILDTNEF-ISIFL 761
            |....:.:..:|..:|..:||||.:|:....|...::.|.:...|:.::.:|:...::| |::|:
  Fly   569 GLAPIVNEFLSWSFWQPLSKLSYCLYIWHLLVETVHIARIKTSLHFSDYDAILRFWSDFGITLFV 633

  Fly   762 ASVALTVLFDAPFQNLKKLLIKR-------PTAAKVVKDSKAKAAESQDATT 806
             |:.:.:..:.|...|:..|:||       |.:.:|  |...:..|...||:
  Fly   634 -SMFMHLCVEVPLGRLEMELLKRCQKKEDSPESPRV--DPSTEPTEVIPATS 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drd	NP_001033845.1	NRF	169..>289	CDD:214781	27/123 (22%)
		OafA	371..791	CDD:224748	119/454 (26%)
		Acyl_transf_3	384..770	CDD:280013	109/411 (27%)
CG42329	NP_608590.2	NRF	71..179	CDD:214781	30/141 (21%)
		OafA	253..648	CDD:224748	110/418 (26%)
		Acyl_transf_3	253..639	CDD:280013	109/409 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920