DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drd and oac-6

DIOPT Version :9

Sequence 1:	NP_001033845.1	Gene:	drd / 318102	FlyBaseID:	FBgn0260006	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_507118.1	Gene:	oac-6 / 180094	WormBaseID:	WBGene00007833	Length:	705	Species:	Caenorhabditis elegans

Alignment Length:	685	Identity:	169/685 - (24%)
Similarity:	270/685 - (39%)	Gaps:	167/685 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 DNFDLWALKMHDSSGKLNSGILNGNINQPGDFDQCLGIQQRMNQDQDAGQDQDGDSIIRGQYCLA 230
            |||  :|::.:|:.||:.   |.|....|..||               |..|:.:.|...:|...
Worm    79 DNF--YAVEQYDAWGKIP---LTGLFQLPILFD---------------GSYQECERISGKKYATN 123

  Fly   231 YAQPVLPHNSKRLKSFFKLIQSHGPFKSEFNDPGHRVPRYSLINWGLCVPSGCSARDVEYSVAEY 295
            |...||.                 |.|:........:|........:|:|..||.:|:. :|...
Worm   124 YCYMVLM-----------------PGKNATCHMSDGLPTTFFFRGAVCMPYSCSEQDLP-TVYNQ 170

  Fly   296 LGNQ--TASTGI--TFNVRVEPQMCQVRDQRPWDRNTTWAVRFFLLV-LSVAVLSTIYDRSTKSQ 355
            :.:|  ||....  ::.|:..|..              |....|:.| :.:|:|:|:.|....:.
Worm   171 VSDQPFTACAAFCSSYPVKKTPAF--------------WGFTSFMAVMIGIALLATVIDYLKDAL 221

  Fly   356 PKQN---------PWFTAFSLDKNLRWLFST-SSAPGDIEAVHGIRFLNAIMLIFSH-------- 402
            .|::         .....|||..|...|.|. ...||.|:.:..||||:.:.::..|
Worm   222 KKEDEKREDSRILQILLTFSLWTNAELLLSVKEQKPGFIKCLDCIRFLSMLWVVTGHTFSYLTTP 286

  Fly   403 ---KSMAMFFNPYNNRTAMSESLGQPWTVIGRAASLYTDPFLLFSGMLTSYSLFGRLMK----QQ 460
               :|:..||..:.|...|:             |....|.|.|.||::.||..|...:|    :.
Worm   287 DQIESILPFFGRFWNHLVMN-------------AFYSVDTFFLLSGLVVSYLFFKTKLKVSQIKS 338

  Fly   461 PIRLKNEYISRLMRIVPPLAALI-LFCTYVLPLWGSG--PQWNLVVGHHADICKKNWWRNLLFIH 522
            ||.....|:.|.:|:.|||...: .|..|.....|.|  .|.|...| ..|.|:..||:||::|:
Worm   339 PITWILFYVHRYLRLTPPLMFFLGFFVVYGKYFQGPGVASQLNQQNG-EVDTCQTYWWKNLIYIN 402

  Fly   523 NYFGFSEMCLTHTHHLGIDTELFAVAPLLILALWRWPRRGLFALLLLCTVGTAARYYTTIVNQLS 587
            |.......|...|.:||.||:|:.|||:.::.|:       |:.    .:|||.....||.:.::
Worm   403 NLMSGDTQCYGITWYLGADTQLYLVAPIFLIGLY-------FSF----AIGTALLTAATIGSVIT 456

  Fly   588 NYIYFGT-NIQRLF-------RTADYMYSFPPHRSTVYIMGILLGYVLRKY--QNARLSSLQLRL 642
            .||.|.| ::...|       ...|.:|..|..|...|.:|||:||:|..|  :..||:......
Worm   457 VYILFSTYDLPADFFGNGDATHFYDMIYIKPWIRCPPYFVGILVGYLLATYGKRKLRLNWALAVT 521

  Fly   643 GWLVA----TVCVLASLLGPAPMGDINYVYNST------HAAIYAAFAPIAWCLFFSWIVFVSHN 697
            ||:||    .:|:.::           |.|::.      ..|.|..|:.:||....||::..:|.
Worm   522 GWIVAFSLGALCIFST-----------YDYDNKVKWSIFSRATYYNFSRLAWSFALSWVIVANHM 575

  Fly   698 GYTNKLTKLFAWRGFQVSTKLSYAIYLTQFPV--FFFNVGRRRHIHHYYNFVSIILDTNEFISIF 760
            |:...:....:...:|...:|||..|:..:.|  .:..:| ...||.|.:|           .||
Worm   576 GWGGPIDAFMSHPMWQPFGRLSYCAYIVHYVVLYMYLMIG-DASIHFYSSF-----------QIF 628

  Fly   761 L-ASVALTV-----------LFDAPFQNLKKLLIK 783
            : .:|..||           ||:.||..|:|:||:
Worm   629 MYYAVPTTVLSYIFAFFWSCLFEIPFLKLEKMLIE 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drd	NP_001033845.1	NRF	169..>289	CDD:214781	24/119 (20%)
		OafA	371..791	CDD:224748	124/466 (27%)
		Acyl_transf_3	384..770	CDD:280013	112/437 (26%)
oac-6	NP_507118.1	NRF	80..185	CDD:214781	30/142 (21%)
oac-6	NP_507118.1	Acyl_transf_3	260..644	CDD:376607	112/431 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820