DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drd and oac-55

DIOPT Version :9

Sequence 1:	NP_001033845.1	Gene:	drd / 318102	FlyBaseID:	FBgn0260006	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_001317839.1	Gene:	oac-55 / 178792	WormBaseID:	WBGene00021479	Length:	742	Species:	Caenorhabditis elegans

Alignment Length:	787	Identity:	199/787 - (25%)
Similarity:	318/787 - (40%)	Gaps:	196/787 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 EYQTANL-SQLHAVTPGNYTIHQMEQAEDDDDQVEEDERAYL-YNIGKRFLAITQPFDAARN--- 147
            :|:|::| :.|...:..||:|          .|...:|.::| |.:          .||||.
Worm    51 KYKTSDLIAALGIHSNANYSI----------SQECHEELSFLGYGV----------IDAARYARH 95

  Fly   148 ------PDASTLCRRQMHQFLNALDNFDLWALKMHDSSGKLNSGILNGNINQPGDFDQCLGIQ-- 204
                  |.:.|...|:.            :.:.|.|::|||.|||:.|:|...|.|.:|..||
Worm    96 HSTAAVPASMTDQERKD------------YLIPMMDAAGKLGSGIVRGHILSTGAFSECKSIQMF 148

  Fly   205 -QRMNQDQDAGQDQDGDSIIRGQYCLAYAQPVLPHNSKRLKSFFKLIQSHGPFKSEFNDPGHRVP 268
             ..:|:            .::|.|   |:..:|          |.:......|.|..|.|
Worm   149 SSSLNR------------TVQGDY---YSSRIL----------FDMKMRPNSFNSSCNLP----- 183

  Fly   269 RYSLINWGLCVPSGCSARDVEYSVAEYLGNQTASTGITFNVRVEPQMCQVR--DQR-PWDRNTTW 330
               .|...||:|..|...|:.....|.||...|.:.:          |.||  :|| |.....||
Worm   184 ---QIGVDLCLPWSCRNEDLTGYFREALGPSKALSPV----------CSVRNVNQRVPVISLGTW 235

  Fly   331 AVRFFL-LVLSVAVLSTIYDRSTKSQPKQNP-------W--FTAFSLDKNLRWLFSTSSA--PGD 383
            .|...| |::.:.:||...|...|.|.....       |  |:|||..:||:.:|:|.:.  .|.
Worm   236 IVLLILSLIVGLCILSGFSDIFQKFQLNDKTRKEEGFGWKLFSAFSFHRNLKEIFNTKNCHKEGQ 300

  Fly   384 IEAVHGIRFLNAIMLIFSHKSMAMFF---NPYNNRTAMSESLGQPWTVIGRAASLYTDPFLLFSG 445
            :.:::.||.::...:||.|.|...|.   ||.:......::  ...|:|.. |....|.|...|.
Worm   301 VTSLNCIRVISTFWVIFGHCSEITFMVITNPIDLYDFTKDT--YTGTLISN-AYFSVDTFFFISA 362

  Fly   446 MLTSYSLFGRLMKQQPIRLKNE-----YISRLMRIVPPLAALILFCTYV-------LPLWGSGPQ 498
            .|.|:..|.:|.||....|...     |:.|:.|:.|.....|||.|:|       :|.:    .
Worm   363 FLLSFLWFKQLEKQWNALLSPGGWLMFYVHRIARLSPVYYVTILFFTFVFTRSMVDMPAF----M 423

  Fly   499 WNLVVGHHADICKKNWWRNLLFIHNYFGFSEMCLTHTHHLGIDTELFAVAPLLILALWRWPRRGL 563
            ...||.   |.|:.::|.|||:|.|..|..::|...:.:|..|.:::.::||::|:.      ||
Worm   424 TPAVVD---DTCQNSYWVNLLYIQNIVGPKDICYFISWYLATDLQIYIMSPLILLSF------GL 479

  Fly   564 FALLLLCTVGTAARYYTTIVNQL---------SNYIYFGTNIQRLF-----RTADYMYSFPPHRS 614
            ...::...:.|||...:|..|..         |:|.| |.. ..|:     |.|.:.|..|..|.
Worm   480 GGAVVGLLISTAAFLASTAFNAYQMIFWHFPPSDYNY-GPK-DPLYDPSKRRYAAWNYHNPLIRC 542

  Fly   615 TVYIMGILLGYVLRKYQNARLSSLQLRLGWLVATVCVLASLLGPAPMGDINYV------YNSTH- 672
            .:||||::|||.:|:.....::....|:.|.::             :|.:.:|      |.|.|
Worm   543 QIYIMGMVLGYFMRRIPKININPWVDRIMWCLS-------------LGSMIFVIVIMEDYTSGHL 594

  Fly   673 -----AAIYAAFAPIAWCLFFSWIVFVSH--NGYTNKLTKLFAWRGFQVSTKLSYAIYLTQFPV- 729
                 .|:|:.|:.:.|.|..||||..::  .|..||...|..|...   .:||:..||....|
Worm   595 WSPLQTALYSCFSRVVWGLALSWIVISTYYRKGLINKFMSLPVWTPL---ARLSFCAYLVHLMVA 656

  Fly   730 -FFFNVGRRRHIHHYYN----FVSIILDTNEFISI-FLASVALTVLFDAPFQNLKKLLI---KRP 785
             :||.   |.|...|::    ||.:|  ....||. ||.::..:.:|:.||..::.||:   .|.
Worm   657 AYFFG---RNHSELYFSTLPYFVLVI--AIPVISCSFLVAIFWSTMFELPFAKVEALLLGGGSRS 716

  Fly   786 TAAKVVK 792
            :|..:.|
Worm   717 SAPDIPK 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drd	NP_001033845.1	NRF	169..>289	CDD:214781	31/122 (25%)
		OafA	371..791	CDD:224748	123/474 (26%)
		Acyl_transf_3	384..770	CDD:280013	112/435 (26%)
oac-55	NP_001317839.1	NRF	111..220	CDD:214781	36/163 (22%)
oac-55	NP_001317839.1	OafA	299..690	CDD:224748	112/429 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I8105
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820