DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drd and ndg-4

DIOPT Version :9

Sequence 1:	NP_001033845.1	Gene:	drd / 318102	FlyBaseID:	FBgn0260006	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_001022618.1	Gene:	ndg-4 / 175582	WormBaseID:	WBGene00003577	Length:	687	Species:	Caenorhabditis elegans

Alignment Length:	687	Identity:	163/687 - (23%)
Similarity:	263/687 - (38%)	Gaps:	156/687 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 WALKMHDSSGKLNSGILNGNINQPGDFDQCLGIQQRMNQDQDAGQDQDGDSIIRGQYCLAYAQPV 235
            |.||..||.||..:||.:||....||::.|..:.              .|....||||....:
Worm   112 WVLKWFDSLGKPAAGITDGNYYWLGDYELCAALA--------------SDGSFDGQYCRIEME-- 160

  Fly   236 LPHNSKRLKSFFKLIQSHGPFKSEFNDPGHRVPRYSLINWGLCVPSGCSARDVEYSVAEYLGNQT 300
            :|...         ::|..|    ..||      .|:| .|:|.||.||..|:         ...
Worm   161 VPDAG---------VESGCP----QTDP------LSII-LGVCFPSACSVADL---------TTV 196

  Fly   301 ASTGITFNVRVEPQMCQVRDQRPWDRNTTWAVRFFLLVLSVAVLSTIYDRSTKSQPKQNPWFTAF 365
            :|..:.:|::||   |:  .|..|    ::.....|::|.|.::....  :|......:...:.|
Worm   197 SSIYLPYNLKVE---CE--SQNRW----SFVTVLLLIILMVWIVPQAV--ATFQTSSNDSILSCF 250

  Fly   366 SLDKNLRWLFSTSSAPGDIEAVHGIRFLNAIMLIFSHKSMAMFFN---PYNNRTAMS-ESLGQ-P 425
            |:..|.:..|||.....::..|||:.||    |.|:..| .|.:|   ||....|.: |.:.. |
Worm   251 SIPDNAKRTFSTRRESPNLHVVHGLEFL----LFFTIVS-GMVYNFMLPYIENVAFAFEGVSSFP 310

  Fly   426 WTVIGRAASLYTDPFLLFSGMLTSYSLFGRLMKQQPIRLKNEYI-SRLMRIVPPLAALILFCTYV 489
            ..::.. .|...|..|..|...|:|.|||.::   .:|...:|| .||.|..|.....:||...:
Worm   311 MHIVNN-YSYQIDGLLALSAFYTTYLLFGNIL---TLRSAFDYILMRLFRFWPAYIVCVLFMYVI 371

  Fly   490 LPLWGSGPQWNLVVGHHADI---CKKNWWRNLLFIHNYFGFSEMCLTHTHHLGIDTELFAVAPLL 551
            .|...|||.|     .|.|.   |...||:|:|||:|:|..::.|:...:.:.::.:.:|:...:
Worm   372 FPGVSSGPMW-----IHTDTVNRCGSGWWKNILFINNWFNVTDTCVDIGYVISMEAQYYAILIFV 431

  Fly   552 ILALWRWPRRGLFALLLLCTVGTAARYYTTIVNQLSNYIYFGTNIQRLFRTADYMYSFPP----- 611
            |....::|                      ::.||..|..||::|...|..| |....||
Worm   432 IFLSSKYP----------------------LLTQLFAYTVFGSSIIFSFVRA-YSQELPPAPMLT 473

  Fly   612 ---------------------HRSTVYIMGILLGY-VLRKYQNARLSSLQLRLGWLVATVCV--- 651
                                 .||:.|.:|.:.|. ........|.|.|...:..|:|.:|:
Worm   474 LEPVPLTKVYAVFDQLLLSLFARSSNYCLGFIFGIGCATASDELRESGLSYCMHKLLAIICIAFA 538

  Fly   652 LASLLGPAPMGDINYVYN-STHAAIYAAFAPIAWCLFFSWIVFVSHNGYTNK--LTKLFAWRGFQ 713
            :...:|..|.....:|.| ....|.|||.....|.......|::.|:|..:|  |..|..||.|.
Worm   539 VVPFVGAFPYSAYAWVSNFEIMNASYAALHRPMWSFALLSFVYLCHHGAFSKEWLNALLEWRVFA 603

  Fly   714 VSTKLSYAIYLTQFPV---FFFNVGRRRHIHHYYNFVSIILDTNEFISIFLASVALTVLFDAPFQ 775
            ..:|:::...:...|:   ||.::.:..:..|:....:.|            |.||...|.|.|.
Worm   604 PLSKVTWIALVVAEPIILYFFSSLNKPAYATHWSTMYTAI------------STALLAYFVAMFL 656

  Fly   776 NLKKLLIKRPTAAKVVKDSKAKAAESQDATTTTLASQ 812
            :   :.:.||....:..:.|.:.|:   |.|...|:|
Worm   657 D---IFVTRPIRYLIYPEQKHRYAQ---AHTQDQAAQ 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drd	NP_001033845.1	NRF	169..>289	CDD:214781	33/117 (28%)
		OafA	371..791	CDD:224748	110/464 (24%)
		Acyl_transf_3	384..770	CDD:280013	102/430 (24%)
ndg-4	NP_001022618.1	NRF	110..215	CDD:214781	39/152 (26%)
ndg-4	NP_001022618.1	OafA	325..668	CDD:224748	90/388 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28870
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030