Protein Alignment HNRNPA2B1 and Rbp6

DIOPT Version :10

• Sequence 1: NP_112533.1
• Gene: HNRNPA2B1 / 3181
• HGNCID: 5033
• Length: 353
• Species: Homo sapiens
• Sequence 2: NP_001097631.1
• Gene: Rbp6 / 39919
• FlyBaseID: FBgn0260943
• Length: 499
• Species: Drosophila melanogaster
• Alignment Length: 151
• Identity: 37/151 - (24%)
• Similarity: 52/151 - (34%)
• Gaps: 35/151 - (23%)

Human   174 PTQTPHQEAAPRASKGAQTGTLVEE-----MVAVASGTAGGDD-----GGAAGRPLTKAQPGHRS 228
            ||.:...:.|....:....|.:.|:     ||.:|..:||..|     ||..|.....|:..|
  Fly     6 PTVSEDYKKAVEKCRRKLRGLIAEKNCAPIMVRLAWHSAGTFDCQSRTGGPFGTMRFDAEQAH-- 68

Human   229 YNLQERRRIGSMTGVEQALLPRVPTDESEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGST 293
                     |:.:|:..||....|..| :..|::.||        |..:.||    |.....|..
  Fly    69 ---------GANSGIHIALRLLDPIRE-QFPTISFAD--------FHQLAGV----VAVEVTGGP 111

Human   294 QAA-REGREPGPTPRARPRAP 313
            ... ..|||..|.|....|.|
  Fly   112 DIPFHPGREDKPQPPPEGRLP 132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPA2B1	NP_112533.1	Nuclear localization signal. /evidence=ECO:0000255	9..15
		RRM1_hnRNPA2B1	19..99	CDD:410155
		RRM2_hnRNPA2B1	112..191	CDD:409995	3/16 (19%)
		Disordered. /evidence=ECO:0000269|PubMed:26544936	193..353		34/132 (26%)
		HnRNPA1	302..326	CDD:463312	4/12 (33%)
		Nuclear targeting sequence. /evidence=ECO:0000250	308..347		2/6 (33%)
Rbp6	NP_001097631.1	RRM1_MSI	30..105	CDD:409990	24/98 (24%)
		RRM2_MSI	119..192	CDD:240769	6/14 (43%)