Protein Alignment HNRNPA2B1 and lark

DIOPT Version :10

• Sequence 1: NP_112533.1
• Gene: HNRNPA2B1 / 3181
• HGNCID: 5033
• Length: 353
• Species: Homo sapiens
• Sequence 2: NP_523957.1
• Gene: lark / 38811
• FlyBaseID: FBgn0011640
• Length: 352
• Species: Drosophila melanogaster
• Alignment Length: 258
• Identity: 62/258 - (24%)
• Similarity: 106/258 - (41%)
• Gaps: 61/258 - (23%)

Human    22 KLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAE-VDAAMAARPHS 85
            |||||.|..:|....||..:|::|.:.:|.|:::        :|||...:..: .||......::
  Fly     8 KLFIGNLDEKTQATELRALFEKYGTVVECDVVKN--------YGFVHMETEQQGRDAIQNLNGYT 64

Human    86 IDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSG 150
            ::...::.:.|.:|.....|     ..|:|||.:.:.|....:|:.|::||.:...:|:
  Fly    65 LNEFAIKVEAAKSRRAPNTP-----TTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIV------ 118

Human   151 KKRGFGFVTFD-DHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQ-----EVQSSRSGRGGNFG- 208
              |.:|||..| ..|..|.|.......::|...:|:.:.||...:     ..|..|.||.|::.
  Fly   119 --RNYGFVHLDCVGDVQDAIKELNGRVVDGQPLKVQVSTSRVRPKPGMGDPEQCYRCGRSGHWSK 181

Human   209 -----FGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFG-------------------DGYNGY 247
                 :|.:  |||...|.|.|     :.|| ..|.:|                   ||:..|
  Fly   182 ECPRLYGSA--GGGREPPSPLS-----AGGY-RDRMYGRDPYPPPPPPPPFLRDRIMDGFRDY 236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPA2B1	NP_112533.1	Nuclear localization signal. /evidence=ECO:0000255	9..15
		RRM1_hnRNPA2B1	19..99	CDD:410155	19/77 (25%)
		RRM2_hnRNPA2B1	112..191	CDD:409995	21/79 (27%)
		Disordered. /evidence=ECO:0000269|PubMed:26544936	193..353		19/85 (22%)
		HnRNPA1	302..326	CDD:463312
		Nuclear targeting sequence. /evidence=ECO:0000250	308..347
lark	NP_523957.1	RRM1_2_CoAA_like	8..73	CDD:409779	18/72 (25%)
		RRM1_2_CoAA_like	87..152	CDD:409779	19/72 (26%)
		hnRNP-R-Q	<88..>258	CDD:273732	40/165 (24%)