Protein Alignment HNRNPA2B1 and CG12288

DIOPT Version :10

• Sequence 1: NP_112533.1
• Gene: HNRNPA2B1 / 3181
• HGNCID: 5033
• Length: 353
• Species: Homo sapiens
• Sequence 2: NP_609822.1
• Gene: CG12288 / 35027
• FlyBaseID: FBgn0032620
• Length: 435
• Species: Drosophila melanogaster
• Alignment Length: 260
• Identity: 54/260 - (20%)
• Similarity: 92/260 - (35%)
• Gaps: 73/260 - (28%)

Human     1 MEKTLETVPLERKK-------------REKEQFRKL----------FIGGLSFETTEESLRNYYE 42
            :||...|.|.|:.|             :::|..:::          |:|.|...|....|...::
  Fly   112 VEKEPTTAPNEKPKGKVSKKAKANANNKDEEGVKRIRNPAEEASTVFVGNLPINTKRVQLVKLFQ 176

Human    43 QWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGA 107
            .:| |...:.:|....|:       .|.......|.      |::..||..|..:|::.....|:
  Fly   177 PYG-LVQSIRLRTAGGKQ-------LFKHKQRKVAG------SLNAYVVLEKPEIAQQALALNGS 227

Human   108 -----HVTV-----------------------KKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEII 144
                 |:.|                       :.:|||.:|....|..||:.|...|:||.|..:
  Fly   228 EFKENHLRVTPASMAEKFGQAKDKQPSDKDAKRTIFVGSLKYSATEEQLREIFSSCGEIDYIRCL 292

Human   145 TDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHT------INGHNAEVRKALSRQEMQEVQSSRSGR 203
            .|...|.| |..:|.|...|.|. :.|:...|      ||....:|:|..::|......:|.:.:
  Fly   293 QDGDKGCK-GVAYVCFQKPDAVG-LALELNQTLLDDRPINVERYQVKKLGAKQVRDAAAASAASK 355

Human   204  203
              Fly   356  355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPA2B1	NP_112533.1	Nuclear localization signal. /evidence=ECO:0000255	9..15		3/18 (17%)
		RRM1_hnRNPA2B1	19..99	CDD:410155	15/89 (17%)
		RRM2_hnRNPA2B1	112..191	CDD:409995	26/84 (31%)
		Disordered. /evidence=ECO:0000269|PubMed:26544936	193..353		1/11 (9%)
		HnRNPA1	302..326	CDD:463312
		Nuclear targeting sequence. /evidence=ECO:0000250	308..347
CG12288	NP_609822.1	RRM1_RBM34	156..237	CDD:409828	18/94 (19%)
		RRM_SF	261..332	CDD:473069	24/72 (33%)