Protein Alignment HNRNPA2B1 and Hrb27C

DIOPT Version :10

• Sequence 1: NP_112533.1
• Gene: HNRNPA2B1 / 3181
• HGNCID: 5033
• Length: 353
• Species: Homo sapiens
• Sequence 2: NP_476869.1
• Gene: Hrb27C / 33968
• FlyBaseID: FBgn0004838
• Length: 421
• Species: Drosophila melanogaster
• Alignment Length: 394
• Identity: 128/394 - (32%)
• Similarity: 188/394 - (47%)
• Gaps: 79/394 - (20%)

Human    16 EKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMA 80
            |:::..|||:||||:|||:|:|..|:.::|.:.|||||::..|.||||||||||:....|:..:.
  Fly     2 EEDERGKLFVGGLSWETTQENLSRYFCRFGDIIDCVVMKNNESGRSRGFGFVTFADPTNVNHVLQ 66

Human    81 ARPHSIDGRVVEPKRAVAR--EESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEI 143
            ..||::|||.::||....|  ::..|.|.:    |:|:||:..:..|..||.:|..|||:..:.|
  Fly    67 NGPHTLDGRTIDPKPCNPRTLQKPKKGGGY----KVFLGGLPSNVTETDLRTFFNRYGKVTEVVI 127

Human   144 ITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFG 208
            :.|::..|.|||||::|::...|:.:..::|..:||...|::||..|.......|:.|..||.:|
  Fly   128 MYDQEKKKSRGFGFLSFEEESSVEHVTNERYINLNGKQVEIKKAEPRDGSGGQNSNNSTVGGAYG 192

Human   209 -FGDS--------------RGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGG 258
             .|:.              :|..|..| ||..|...|:.      ....||.|:|..|....:
  Fly   193 KLGNECSHWGPHHAPINMMQGQNGQMG-GPPLNMPIGAP------NMMPGYQGWGTSPQQQQY-- 248

Human   259 SPGYG-GGRGGYGGGG---------PGYGNQGG-----GYGGGYDNYG-------GGNYGSGNYN 301
              ||| .|.|.|.|.|         |.:.|..|     || ||||.|.       .|..|.|::|
  Fly   249 --GYGNSGPGSYQGWGAPPGPQGPPPQWSNYAGPQQTQGY-GGYDMYNSTSTGAPSGPSGGGSWN 310

Human   302 DFGNYNQQPSNYGPMKSGNFG----------------GSRNMGGPYGG-GNYGPGGSGGSGG--- 346
               ::|..|::.||..:...|                |..:..||.|| ...|||.|....|
  Fly   311 ---SWNMPPNSAGPTGAPGAGAGTATDMYSRAQAWATGGPSTTGPVGGMPRTGPGNSASKSGSEY 372

Human   347 -YGG 349
             |||
  Fly   373 DYGG 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPA2B1	NP_112533.1	Nuclear localization signal. /evidence=ECO:0000255	9..15
		RRM1_hnRNPA2B1	19..99	CDD:410155	38/79 (48%)
		RRM2_hnRNPA2B1	112..191	CDD:409995	27/78 (35%)
		Disordered. /evidence=ECO:0000269|PubMed:26544936	193..353		58/215 (27%)
		HnRNPA1	302..326	CDD:463312	6/39 (15%)
		Nuclear targeting sequence. /evidence=ECO:0000250	308..347		14/59 (24%)
Hrb27C	NP_476869.1	RRM1_hnRNPA_hnRNPD_like	9..80	CDD:409763	35/70 (50%)
		RRM2_DAZAP1	94..173	CDD:409765	28/82 (34%)