DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32581 and Rnf185

DIOPT Version :9

Sequence 1:	NP_001096988.2	Gene:	CG32581 / 318098	FlyBaseID:	FBgn0052581	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_001019442.1	Gene:	Rnf185 / 360967	RGDID:	1564777	Length:	192	Species:	Rattus norvegicus

Alignment Length:	217	Identity:	109/217 - (50%)
Similarity:	134/217 - (61%)	Gaps:	34/217 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PTNSTASELKKSNTSYSFTGDYLSGGNKADLKGGYPFGGTDTDTKANEKDKEKEHTADDSLYECN 126
            |:.|.::|    |:|        :||......|....||                  .||.:|||
  Rat     6 PSASASTE----NSS--------AGGPSGSSNGTGESGG------------------QDSTFECN 40

  Fly   127 ICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQEDPRNK 191
            ||||||||||:|:||||||||||||||.|||||::||||||.:.:|||||||||.||.|:|||.|
  Rat    41 ICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREK 105

  Fly   192 VPPRPAGQRTEPDPVPGFPGFGFGD-GFHMSFGIGAFPFGFITSRLNFFEPRPPADI--RRLHED 253
            .||||.|||.||:...||.|||||| ||.|||||||||||...:..|..:.|||..:  ...:.|
  Rat   106 TPPRPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPGTPQYVD 170

  Fly   254 EPWALSKLFWHFVVFVIYGLLV 275
            |.: ||:||....:.:::.||:
  Rat   171 EQF-LSRLFLFVALVIMFWLLI 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32581	NP_001096988.2	RING	124..169	CDD:238093	39/44 (89%)
Rnf185	NP_001019442.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		8/35 (23%)
		Required for ubiquitin ligase activity and protection against ER stress-induced cell death. /evidence=ECO:0000250\|UniProtKB:Q96GF1	29..80		40/68 (59%)
		RING-HC_RNF185	38..80	CDD:319658	36/41 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..123		21/32 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346070
Domainoid	1	1.000	138	1.000	Domainoid score	I4725
eggNOG	1	0.900	-	-		E1_COG5574
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34298
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3278
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1510545at2759
OrthoFinder	1	1.000	-	-		FOG0000717
OrthoInspector	1	1.000	-	-		otm46329
orthoMCL	1	0.900	-	-		OOG6_102074
Panther	1	1.100	-	-	O	PTHR12313
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X682
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760