DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc14A and FCGBP

DIOPT Version :9

Sequence 1:	NP_727928.3	Gene:	Muc14A / 318097	FlyBaseID:	FBgn0052580	Length:	16223	Species:	Drosophila melanogaster
Sequence 2:	NP_003881.2	Gene:	FCGBP / 8857	HGNCID:	13572	Length:	5405	Species:	Homo sapiens

Alignment Length:	610	Identity:	116/610 - (19%)
Similarity:	192/610 - (31%)	Gaps:	183/610 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly 15339 AGHT-----TQDSSV-VGLLSKEPTQT-------LTFSKLSPTQIITEKSTTNNLSVHSNIDKST 15390
            ||.|     ||::|| :....:|...|       |.:||..|..:|                 |:
Human    12 AGATLLWGLTQEASVDLKNTGREEFLTAFLQNYQLAYSKAYPRLLI-----------------SS 59

  Fly 15391 ISTQPYFDTDTTKYSTSVGVLSEESSKLTKQNIT----EEITTNILSLPSNIATSTTLTQPHSDT 15451
            :|..|          .||.:||:..:  |.:.:|    |.:..||.:....|.:.
Human    60 LSESP----------ASVSILSQADN--TSKKVTVRPGESVMVNISAKAEMIGSK---------- 102

  Fly 15452 DKTEAIQNQTTAGHTTQDSSVIGLLSKEPTQTLTFSKLSPTQ-------IITEKSTS----NNLS 15505
                 |.......|:....||..|.:|..|..||.  |.|.|       ::|...||    ...:
Human   103 -----IFQHAVVIHSDYAISVQALNAKPDTAELTL--LRPIQALGTEYFVLTPPGTSARNVKEFA 160

  Fly 15506 VHSNIDNSTIS-TQPYFDTDTTKYSTSVGVLSEESSKLTKQNITEEITTNILSLPSNI---ATST 15566
            |.:....:::| |.....|...|:..:..||     ::|.|      ..|:..|.|::   .:..
Human   161 VVAGAAGASVSVTLKGSVTFNGKFYPAGDVL-----RVTLQ------PYNVAQLQSSVDLSGSKV 214

  Fly 15567 TLTQPHSDTDKTEAIQNQTTAGHTTQD---------SSVIGLLSKEPTQTLTFSKLSPTQIITEK 15622
            |.:.|.:........|..||..|..:.         ..|:..|:.:....|.|...|....:|..
Human   215 TASSPVAVLSGHSCAQKHTTCNHVVEQLLPTSAWGTHYVVPTLASQSRYDLAFVVASQATKLTYN 279

  Fly 15623 ----STTNNLSVHSNIDNSTISTQPYFDTDTTKYSTSVGVLSEESSKLTKQNITEEITTN----- 15678
                :.:..|.....::.....:.|.:      .|.:||:   :........|..|:|.:
Human   280 HGGITGSRGLQAGDVVEFEVRPSWPLY------LSANVGI---QVLLFGTGAIRNEVTYDPYLVL 335

  Fly 15679 ------------ILSLPSNIATSTTLTQPHSDTDKTETIQNQTTAGHTTQDSSVIGLLSKEPTQT 15731
                        :.|:|.....:..:.|       |:.|...|..||     :|...|:.|....
Human   336 IPDVAAYCPAYVVKSVPGCEGVALVVAQ-------TKAISGLTIDGH-----AVGAKLTWEAVPG 388

  Fly 15732 LTFS----KLSPTQIITEKSTSNNLSVHSNIDNSTISTQPYFDTDTTKYSTSVGVLSEASSKLTK 15792
            ..||    :|....:|.....:.||.:.                 |...:.::|..:.|....|.
Human   389 SEFSYAEVELGTADMIHTAEATTNLGLL-----------------TFGLAKAIGYATAADCGRTV 436

  Fly 15793 QNITEKSTTNILSLPSN-----------IATSTTLTQ----PHFYTDKTETTGNQTSTEHTSKYS 15842
            .:..|.|...:......           :|.||.:.:    ||:    |...|.:.....|..|
Human   437 LSPVEPSCEGMQCAAGQRCQVVGGKAGCVAESTAVCRAQGDPHY----TTFDGRRYDMMGTCSY- 496

  Fly 15843 TTVEFLSKEQTSIIPTFSKLEPTEH 15867
            |.||..|::.|  :|.||.....||
Human   497 TMVELCSEDDT--LPAFSVEAKNEH 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc14A	NP_727928.3	PRK14949	<11377..11776	CDD:237863
		PRK08581	11922..>12215	CDD:236304
		PRK14949	<13679..14114	CDD:237863
		PRK14949	<14663..15055	CDD:237863
FCGBP	NP_003881.2	IgGFc-binding	24..450		92/520 (18%)
		VWD	472..627	CDD:278521	16/55 (29%)
		C8	667..742	CDD:214843
		TIL	745..799	CDD:280072
		VWD	864..1019	CDD:278521
		C8	1060..1133	CDD:214843
		TIL	1136..1189	CDD:280072
		VWC	1194..1245	CDD:302663
		VWD	1252..1407	CDD:278521
		C8	1454..1529	CDD:214843
		TIL	1532..1585	CDD:280072
		VWC	1587..1640	CDD:302663
		VWD	1673..1832	CDD:278521
		C8	1871..1946	CDD:214843
		TIL	1950..2004	CDD:280072
		VWD	2072..2222	CDD:278521
		C8	2260..2334	CDD:214843
		TIL	2337..2390	CDD:280072
		VWC	2398..2446	CDD:302663
		VWD	2453..2608	CDD:278521
		C8	2655..2730	CDD:214843
		TIL	2733..2786	CDD:280072
		VWC	2788..2841	CDD:302663
		VWD	2874..3033	CDD:278521
		C8	3072..3147	CDD:214843
		TIL	3151..3205	CDD:280072
		VWD	3273..3423	CDD:278521
		C8	3461..3535	CDD:214843
		TIL	3538..3591	CDD:280072
		VWC	3599..3647	CDD:302663
		VWD	3654..3809	CDD:278521
		C8	3856..3931	CDD:214843
		TIL	3934..3987	CDD:280072
		VWC	3989..4042	CDD:302663
		VWD	4075..4234	CDD:278521
		C8	4273..4348	CDD:214843
		TIL	4352..4406	CDD:280072
		VWD	4474..4624	CDD:278521
		C8	4662..4736	CDD:214843
		TIL	4739..4792	CDD:280072
		VWC	4797..4849	CDD:302663
		VWD	4856..5003	CDD:278521
		C8	5044..5118	CDD:214843
		TIL	5121..5174	CDD:280072
		VWD	5235..5382	CDD:295339
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900