Protein Alignment Muc14A and HPF1

DIOPT Version :9

• Sequence 1: NP_727928.3
• Gene: Muc14A / 318097
• FlyBaseID: FBgn0052580
• Length: 16223
• Species: Drosophila melanogaster
• Sequence 2: NP_014487.1
• Gene: HPF1 / 854010
• SGDID: S000005515
• Length: 967
• Species: Saccharomyces cerevisiae
• Alignment Length: 1197
• Identity: 265/1197 - (22%)
• Similarity: 432/1197 - (36%)
• Gaps: 352/1197 - (29%)

  Fly 14662 WTPSTSLPQTSSKTNITFSSQSVYEDKTSLEDTRTLSISQSREITNSLLTDLSAEDQTNQEETSE 14726
            :|.|:|:...||....:.||.||             |||.|.|:|:|               ||:
Yeast    26 YTNSSSIASNSSTAVSSTSSGSV-------------SISSSIELTSS---------------TSD 62

  Fly 14727 LSKSLPQLTTAESISFQESSAEQNQMTEEPWTLSTSL-PQTSS---KTNITFSSQSVYEDKTSLE 14787
            :|.||.:||:        ||.|          :|:|: |.|||   .::||.|..||
Yeast    63 VSSSLTELTS--------SSTE----------VSSSIAPSTSSSEVSSSITSSGSSV-------- 101

  Fly 14788 DTRTLSISQSITMTNSPLTDLSAEDQTNQEETSELSKSLPQLTTEESISFQESSAEQNQMTEEPW 14852
                 |.|.|||.:.|.::..|:..::....:...|      .||...|...|
Yeast   102 -----SGSSSITSSGSSVSSSSSATESGSSASGSSS------ATESGSSVSGS------------ 143

  Fly 14853 TLSTSLPQTSSKTNITFSSQSVNEDKTSLEDTRTLSISQSITMTNSLLTDLSAEDQTNQEET-SE 14916
              |||:  ||..::.|.|..||:...::.|...:.|.|.|.|.:.|     ||...::..|: |.
Yeast   144 --STSI--TSGSSSATESGSSVSGSTSATESGSSASGSSSATESGS-----SASGSSSATESGSS 199

  Fly 14917 LSKSLPQLTTEESISFQESSAEQNQMTEEPWTLSTSLPQSSSKTNNIFSSQSVNEDKTSLEDTRT 14981
            :|.|.....:..|:|...|:.|...        ::|:|.||.......||.|.:|...:...|.:
Yeast   200 VSGSSSATESGSSVSGSSSATESGS--------ASSVPSSSGSVTESGSSSSASESSITQSGTAS 256

  Fly 14982 ----LSTSQPITITNSPLTDLSAEDQTNQEETSVLSKSLPQLTTEESISFQESSAEQNQMTEEPW 15042
                .|||..:|.:.|.::..||.....      :|.|:||.|         |||.....:....
Yeast   257 GSSASSTSGSVTQSGSSVSGSSASSAPG------ISSSIPQST---------SSASTASGSITSG 306

  Fly 15043 TLSTSPPQSSSKTKNIFSSQSVNEEKTSLEDTRTLSISQSRAITNSLLTDLSAEDQTNKEEISEL 15107
            |||:....:||.|....:|.|.::....|..|   :||....:|.|::.       |...|::..
Yeast   307 TLSSITSSASSATATASNSLSSSDGTIYLPST---TISGDITLTGSVIA-------TEAVEVAAG 361

  Fly 15108 SKSLPQLTTEESISFQESSAEQNQMTEEPWTLSTSPPQSSSNTIKTTETSEEPLCLCTCVIDPDE 15172
            .|    ||                                                   ::|.|:
Yeast   362 GK----LT---------------------------------------------------LLDGDK 371

  Fly 15173 DICSCN------CKITKSIPTGRTTSKHSQWDGSSTKALGLDGTEDQKTFDAT-QNSMTIGLLSK 15230
            .:.|.:      ..:.||.||                   ..|||    ||.: :|....|..:.
Yeast   372 YVFSADFIIHGGVFVEKSKPT-------------------YPGTE----FDISGENFDVSGTFNA 413

  Fly 15231 EPTQTLTFSKLSTTQIITEKSTSNNLSVHSNIDKSTISTQPYFDTDTTKYSTSV---GVLS---- 15288
            |.....:.|..|.|....:.|...:||: |...|..::..||.::....:|.::   |.:|
Yeast   414 EEPAASSASAYSFTPGSFDNSGDISLSL-SESTKGEVTFSPYSNSGAFSFSNAILNGGSVSGLQR 477

  Fly 15289 -EESSKLTKQNIT-EEITTNILSLPSN-------IATSTTLTQPHSDTDKTEAIQNQTTAGHTTQ 15344
             .||..:....|. |..:|.::..|.:       |:.:..|..|.:.|.:|...:.:
Yeast   478 RAESGSVNNGEINLENGSTYVVVEPVSGSGTINIISGNLYLHYPDTFTGQTVVFKGE-------- 534

  Fly 15345 DSSVVGLLSKEPTQTLTFSKLSPTQIITEKSTTNNLSVHSNIDKSTISTQPYFDTDT-------- 15401
                 |:|:.:||:|.|    :|..::   ..|....:....|.:.:|    :|:.|
Yeast   535 -----GVLAVDPTETNT----TPIPVV---GYTGENQIAITADVTALS----YDSATGVLTATQG 583

  Fly 15402 -TKYSTSVGVLSEESSKLTKQNITEEITTNILSLPSNIATSTTLTQPHSDTDKTEAIQNQTTAGH 15465
             :::|.|:|.....|.....:..........|:....:|:|.|    .|.|..|....| :|:|.
Yeast   584 NSQFSFSIGTGFSSSGFNVSEGTFAGAYAYYLNYGGVVASSAT----PSSTSTTSGATN-STSGS 643

  Fly 15466 TTQDSSVIGLLSKEPTQTLTFSKLSPTQIITEKSTSNNLSVHSNIDNSTISTQPYFDTDTTKYST 15530
            |:..:||.|                     :..|||...||..:..::.||..|...|.|..|:|
Yeast   644 TSFGASVTG---------------------STASTSFGASVTGSTASTLISGSPSVYTTTLTYAT 687

  Fly 15531 SVGVLSEESSKLTKQNITEEITTNILSLPSNIATSTTLTQPHSDTDKTEAIQNQTTAGHTTQDSS 15595
            :...:....|:.|..|             .|:.|.|| |.|.|.|..|....::|....||...:
Yeast   688 TTSTVVVSCSETTDSN-------------GNVYTITT-TVPCSSTTATITSCDETGCHVTTSTGT 738

  Fly 15596 VIGLLSKEPTQTLTFSKLSPTQIIT--EKSTTNNLSVHSNIDNSTISTQPYFDTDTTKYSTSVGV 15658
            |       .|:|:: ||...|..:|  :.:..|..:|.|.....|.:|     |.:.|..|:|.|
Yeast   739 V-------ATETVS-SKSYTTVTVTHCDNNGCNTKTVTSECPEETSAT-----TTSPKSYTTVTV 790

  Fly 15659 LSEESSKLTKQNITE---EITTNILSLPSNIATSTTLTQPHSDTDKTETIQNQ------------ 15708
            ...:.:....:.:|.   |.||..:| |... |:.|:||...:...|:|:.::
Yeast   791 THCDDNGCNTKTVTSEAPEATTTTVS-PKTY-TTATVTQCDDNGCSTKTVTSEAPKETSETSETS 853

  Fly 15709 ------TTAGHTTQDSS-----VIGLLSKEPTQTLTFSKLSP---TQIITEKSTSNNLSVHSNID 15759
                  |||..|..|.:     :|.....|.|.|:|.:..||   |.:.:|.|.:.:|:...:..
Yeast   854 AAPKTYTTATVTQCDDNGCNVKIITSQIPEATSTVTATSASPKSYTTVTSEGSKATSLTTAISKA 918

  Fly 15760 NSTISTQPYFDTDTTKYSTSVGVLSEA 15786
            :|.|||   :........||.|::.::
Yeast   919 SSAIST---YSKSAAPIKTSTGIIVQS 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Muc14A	NP_727928.3	PRK14949	<11377..11776	CDD:237863
		PRK08581	11922..>12215	CDD:236304
		PRK14949	<13679..14114	CDD:237863
		PRK14949	<14663..15055	CDD:237863	103/400 (26%)
HPF1	NP_014487.1	Hyphal_reg_CWP	337..617	CDD:403079	66/392 (17%)
		Herpes_BLLF1	<643..937	CDD:282904	82/346 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900