DRSC/TRiP Functional Genomics Resources

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Protein Alignment Muc14A and FRAS1

DIOPT Version :9

Sequence 1:NP_727928.3 Gene:Muc14A / 318097 FlyBaseID:FBgn0052580 Length:16223 Species:Drosophila melanogaster
Sequence 2:NP_079350.5 Gene:FRAS1 / 80144 HGNCID:19185 Length:4012 Species:Homo sapiens


Alignment Length:2899 Identity:515/2899 - (17%)
Similarity:982/2899 - (33%) Gaps:854/2899 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly 13786 FSSQSVNEDKTSLEDTRTLSISQSITM---TNSPL--TDLSAEDQTNQEETSELSKSLPQLTTEE 13845
            ||..:.||..:....|.:|.::.|:.:   :..||  :.|:.:||..:.|  :|...:....|..
Human  1087 FSVHTSNETCSGKIHTPSLHVNGSLILPIGSIKPLDFSLLNVQDQEGRVE--DLLFHVVSTPTNG 1149

  Fly 13846 SISFQESSPLTDLSAEDQTNQEETSELSKSLPQLTTEE---------SISFQESSAE------QN 13895
            .:....:.....|....:.:.::.:|  |.:..:.::|         .||.|:..:|      |.
Human  1150 QLVLSRNGKEVQLDKAGRFSWKDVNE--KKVRFVHSKEKLRKGYLFLKISDQQFFSEPQLINIQA 1212

  Fly 13896 QMTEEPWTLSTSLPQTSSKTNITFSSQSV-YEDKTSLEDTRTLSI------SQSITMTNSPLTDL 13953
            ..|:.|:.|...:...|.....|.::|.: ..|..:.:|. .:.|      .|.:....||.|.:
Human  1213 FSTQAPYVLRNEVLHISRGERATITTQMLDIRDDDNPQDV-VIEIIDPPLHGQLLQTLQSPATPI 1276

  Fly 13954 SAEDQTNQEETSELSKSLPQLTTEESISFQESSAEQNQMTEEPWTLSTSLPQTSSKTNITFSSQS 14018
                  .|.:..|||:.|.....:.|.|..:.:..|..             ...|..||.|..::
Human  1277 ------YQFQLDELSRGLLHYAHDGSDSTSDVAVLQAN-------------DGHSFHNILFQVKT 1322

  Fly 14019 VNEDKTSLE----------DTRTLSISQSITMTNSPLTDLSAEDQTNQEETSELSKSLPQLTTEE 14073
            |.::...|:          :...|.|:..|....:|  ..|||     |...::::..||     
Human  1323 VPQNDRGLQLVANSMVWVPEGGMLQITNRILQAEAP--GASAE-----EIIYKITQDYPQ----- 1375

  Fly 14074 SISFQESSAEQNQMTEEPWTLSTSLP--QTSSKTNITFSSQSVNE--------------DKTSLE 14122
               |.|.....|...:.|......||  :|::.|: ||:.|.:||              |....|
Human  1376 ---FGEVVLLVNMPADSPADEGQHLPDGRTATPTS-TFTQQDINEGIVWYRHSGAPAQSDSFRFE 1436

  Fly 14123 DTRTLSISQSITMTNSPLTDLSAEDQTNQEETSELSKSLPQLTTEESISFQESSAEQNQMTEEPW 14187
               ..|.|.:.|...|.:.:::...||.:.....|..||.....|:.::           ..:|.
Human  1437 ---VSSASNAQTRLESHMFNIAILPQTPEAPKVSLEASLHMTAREDGLT-----------VIQPH 1487

  Fly 14188 TLSTSLSQTSSKTNIIFSSQSVNEDKTS----LGNTRTLSISQSI----TMTNSPLTDLSAEDQT 14244
            :||                 .:|.:|.|    ...|..|..:|.|    ...:||:...:.||..
Human  1488 SLS-----------------FINSEKPSGKIVYNITLPLHPNQGIIEHRDHPHSPIRYFTQEDIN 1535

  Fly 14245 NQEEASELSKSLPQLTTEESISFQESSAEQNQMTEEPWTLS----TSLPQTSSKTNIIFSSQ--- 14302
            ..:.......:.|.|  :|.::|  |.|...:..:..:|:|    || |:.....:::.|.|   
Human  1536 QGKVMYRPPPAAPHL--QELMAF--SFAGLPESVKFHFTVSDGEHTS-PEMVLTIHLLPSDQQLP 1595

  Fly 14303 --SVNEDKTSLGDTRTLSISQSITITNS------LLTDLSAEDQTN--QEETSELSKSLPQLTTE 14357
              .|...:.::....:.|:...:.:.::      |..:|....|..  .:.|:|..:  |..|.:
Human  1596 VFQVTAPRLAVSPGGSTSVGLQVVVRDAETAPKELFFELRRPPQHGVLLKHTAEFRR--PMATGD 1658

  Fly 14358 ESISFQESSAEQNQMTEEPWTLSTSLPQTSSKTNIIFSSQSVNEDKTSLEDTRTLSISQSITMTN 14422
               :|.....|:|.:                        |.:::..::.||:..:|::..:|:| 
Human  1659 ---TFTYEDVEKNAL------------------------QYIHDGSSTREDSMEISVTDGLTVT- 1695

  Fly 14423 SPLTDLSAEDQTNQEETSEL-----------SKSLPQLTTEESISFQESSAEQNQMTEEPWTLST 14476
              :.::..|...:::....|           |||...:|........:||.:     .|.|....
Human  1696 --MLEVRVEVSLSEDRGPRLAAGSSLSITVASKSTAIITRSHLAYVDDSSPD-----PEIWIQLN 1753

  Fly 14477 SLPQSSSKTNNIFSSQSVNEDKTSLGDTRTLSISQSREITNSLLTDLSAEDQTNQE-ETSELSKS 14540
            .||                    |.|....:|.|:..|:  |.:::.:.||..|:: ..|.:.::
Human  1754 YLP--------------------SYGTLLRISGSEVEEL--SEVSNFTMEDINNKKIRYSAVFET 1796

  Fly 14541 LPQLTTAESISFQESSAEQNQMTEEPWTLSTSLPQTSSKTNITFSSQSVYEDK----------TS 14595
            ...|.| :|..|..|..:.|.:..:.:|:..: |..:....|.|:.....::.          .:
Human  1797 DGHLVT-DSFYFSVSDMDHNHLDNQIFTIMIT-PAENPPPVIAFADLITVDEGGRAPLSFHHFFA 1859

  Fly 14596 LEDTRTLSISQSITMTNSP----LTDLSAEDQTNQEETSELSKSLP-QLTTEESISFQESSAEQN 14655
            .:|...|.....|.::..|    :.:....|:...|..|:|..|.| |...|..|.:.:|..|..
Human  1860 TDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASFPIQDVLENYIYYFQSVHESI 1924

  Fly 14656 QMTEKPW----TPSTSLPQTSSKTNITFSSQSVYEDKTSLEDTRTLSISQSREITNSLLTDLSAE 14716
            :.|...:    :..||..:..| .|||...::....:.:|:..| :.:|....|:||        
Human  1925 EPTHDIFSFYVSDGTSRSEIHS-INITIERKNDEPPRMTLQPLR-VQLSSGVVISNS-------- 1979

  Fly 14717 DQTNQEETSELSKSLPQLTTAESISFQESSAEQNQ----MTEEP------WTLSTSLPQTSSKTN 14771
                                  |:|.|:.....|:    :|::|      |..:.|.|..:.:..
Human  1980 ----------------------SLSLQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLENGRVL 2022

  Fly 14772 I---TFSSQSVY----------------EDKTSL-------------------EDTRTLSISQS- 14797
            :   ||:.|.:.                |.:.||                   .||..|:|:|. 
Human  2023 VQGSTFTYQDILAGLVGYVPSVPGMVVDEFQFSLTDGLHVDTGRMKIYTELPASDTPHLAINQGL 2087

  Fly 14798 ---------ITMTNSPLTDLSAEDQ----TNQEETS----ELSK--SLPQLTTEESI-SFQESSA 14842
                     ||..:..:||:.::|.    ..:|:..    ::.|  :|.|::.:..| ||.::..
Human  2088 QLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGNLEQISIKGPIRSFTQADI 2152

  Fly 14843 EQNQMTEEPWTLSTSLPQTSSKTNITFSSQSVNEDKTSLEDTRTLSIS-------QSITMTNSLL 14900
            .|..:   .::..|..|..|    ..|....|:.:...|.| ::.|||       ..||....|:
Human  2153 SQGHV---EYSHGTGEPGGS----FAFKFDVVDGEGNRLID-KSFSISILEDKSPPVITTNKGLV 2209

  Fly 14901 TD-----------LSAEDQTNQEETSELSKSLPQLTTEESISFQESSAEQNQMTEEPWTLSTSLP 14954
            .|           |||.||     .|..::.:.::|.:..:...|.:|       .|....:|..
Human  2210 LDENSVKKITTLQLSATDQ-----DSGPTELIYRITRQPQLGHLEHAA-------SPGIQISSFT 2262

  Fly 14955 QSSSKTNNIFSSQSVNEDKTSLEDTRTLS-----TSQPITITNSPLTD---------LSAEDQTN 15005
            |:...:.|:....|...:|.|...:.|||     .:|...||..|:.|         :..::...
Human  2263 QADLTSRNVQYVHSSEAEKHSDAFSFTLSDGVSEVTQTFHITLHPVDDSLPVVQNLGMRVQEGMR 2327

  Fly 15006 QEETSVLSKSLPQLTTEESISFQESSAEQNQMTEEPWTLSTSPPQ-----SSSKTKNIFSSQ--S 15063
            :..|....|::...|..||::|......::...|.     ||..|     |:...|:|:.::  .
Human  2328 KTITEFELKAVDADTEAESVTFTIVQPPRHGTIER-----TSNGQHFHLTSTFTMKDIYQNRVSY 2387

  Fly 15064 VNEEKTSLEDTRTLSISQSRAITNSLL-------TDLSAEDQTNKEEISELSKSLPQLTTEESIS 15121
            .::...||:|..|.::|..   ||...       ..::|..|..:.:|..:....|::.|...:.
Human  2388 SHDGSNSLKDRFTFTVSDG---TNPFFIIEEGGKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQ 2449

  Fly 15122 FQESSAEQNQMTEEPWTLSTSPPQSSSNTIKTTETSEEPLCLCTCVIDPDEDICSCNCKITKSIP 15186
            :.|..                 ...::|.|    |.:|.|     .:|||.:    :.::...|.
Human  2450 WLEYM-----------------DGKATNLI----TKKELL-----TMDPDTE----DAQLVYEIT 2484

  Fly 15187 TGRTTSKHSQWDGSSTKALGLDGTEDQKTFDATQNSMTIGL----LSKEPTQTLTFSKLSTTQII 15247
            ||   .||...:..      |.......||  ||..:.:||    |.||..:.:    :.:.|.:
Human  2485 TG---PKHGFVENK------LQPGRAAATF--TQEDVNLGLIRYVLHKEKIREM----MDSFQFL 2534

  Fly 15248 TEKSTSNNLSVH-SNIDKSTISTQPYFDTDTTKYSTSVGVLSEESSKLTKQNI----TEEITTNI 15307
            .:.|..|.:|.: .:|..|.||.: |...:.::.:.||.|..:.:..|.:..|    ||:.|.: 
Human  2535 VKDSKPNVVSDNVFHIQWSLISFK-YTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTAS- 2597

  Fly 15308 LSLPSNIATSTTLTQPH--------------------------SDTDKTEAIQNQTT-------- 15338
                   ::|...:||.                          :|.|..|.:::.|.        
Human  2598 -------SSSRVSSQPGQQDYVEYAGQVQFDEREDTKSCTIVINDDDVFENVESFTVELSMPAYA 2655

  Fly 15339 -AGHTTQDSSVVGLLSKEPTQTLTFSK------------LSPTQIITEKSTTNNL--SVHSNIDK 15388
             .|..||...::.....||  ||.|.|            .:|   |..|...:::  ::...:.|
Human  2656 LLGEFTQAKVIINDTEDEP--TLEFDKKIYWVNESAGFLFAP---IERKGDASSIVSAICYTVPK 2715

  Fly 15389 STISTQPY--------------------FDTDTTKYSTSVGVLSEESSKLTKQNITEEITTNILS 15433
            |.:.:..|                    |....|..:..|.::.:     ::....||....:..
Human  2716 SAMGSSLYALESGSDFKSRGMSAASRVIFGPGVTMSTCDVMLIDD-----SEYEEEEEFEIALAD 2775

  Fly 15434 LPSN-----IATSTTLTQPHSDTDKTEAIQNQTTAGHTTQDSSVIGL-LSKEPTQTLTFSKLSPT 15492
            ...|     :||:..|....:|. .|.::.|  ||...::|:..:.: :.:..|...||:     
Human  2776 ASDNARIGRVATAKVLISGPNDA-STVSLGN--TAFTVSEDAGTVKIPVIRHGTDLSTFA----- 2832

  Fly 15493 QIITEKSTSNNLSVHSNIDNSTISTQPYFDTDTTKYSTSVGVLSEESSKLTKQNITEEITTNILS 15557
            .:......|:..|....:|....|.:..|.....:...::.:|.:     |:..:.|.:.|.::.
Human  2833 SVWCATRPSDPASATPGVDYVPSSRKVEFGPGVIEQYCTLTILDD-----TQYPVIEGLETFVVF 2892

  Fly 15558 LPSNIATSTTLTQPHSDTDKTEAIQNQTTAGHTTQDSSVI-------------GLLSKEPTQTLT 15609
            |.|  |....||:|         .|.......|.||...:             |:|....|::..
Human  2893 LSS--AQGAELTKP---------FQAVIAINDTFQDVPSMQFAKDLLLVKEKEGVLHVPITRSGD 2946

  Fly 15610 FSKLSPTQIITEKSTT---NNLSVHSNIDNSTISTQPYFDTDTTKYSTSVGVLSEESSKLTKQNI 15671
            .|..|..:..|:..:.   .:.....|.|:|.|:   :...|..|..|   |...:.|...    
Human  2947 LSYESSVRCYTQSHSAQVMEDFEERQNADSSRIT---FLKGDKVKNCT---VYIHDDSMFE---- 3001

  Fly 15672 TEEITTNILSLP------------SNIATSTTLTQPHSDTDKTETIQNQTTAGHTTQDS--SVIG 15722
            .||.....|.||            :|:||.|.     |:.:...||:.:..|....:.:  ..|.
Human  3002 PEEQFRVYLGLPLGNHWSGARIGKNNMATITI-----SNDEDAPTIEFEEAAYQVREPAGPDAIA 3061

  Fly 15723 LLS----KEPTQTLTFSKLSPTQIITEKSTSNNLSVHSNIDNSTISTQPYFDTDTTKYSTSVGVL 15783
            :|:    :...|..| ||:        :.::.:.|..|.:|....|....|..........|.:|
Human  3062 ILNIKVIRRGDQNRT-SKV--------RCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEIL 3117

  Fly 15784 S-------EASSKL------TKQNITEKSTTNILSLPSNIATSTTLTQP--------HFYTDKTE 15827
            |       |:.|.:      .:..:.:.:|..:..|....|.|..|..|        :.:.::..
Human  3118 SNEDREWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLILPAPPIVVTLADYDHVEEVT 3182

  Fly 15828 TTGNQTSTE-------------HTSKYSTTVEFLSK---EQTSIIPTFSKLEPTEHISNNKKFTS 15876
            ..|.:.|..             |..:|:...|..|:   .|||:..::....||:         .
Human  3183 KEGVKKSPSPGYPLVCVTPCDPHFPRYAVMKERCSEAGINQTSVQFSWEVAAPTD---------G 3238

  Fly 15877 NGTTEYVISQSNNKTYSDSQLISTTENLILTA--SSQPTDVN-VWKEIDK--------RLDDLQN 15930
            ||      ::|..:|.:|:...::..:::|.:  .|:...|. |.|.:||        |    .|
Human  3239 NG------ARSPFETITDNTPFTSVNHMVLDSIYFSRRFHVRCVAKAVDKVGHVGTPLR----SN 3293

  Fly 15931 KYTIRDNNSLDNS------------------------EFKEKFSQINSSIHLNQLPGNIRASLYA 15971
            ..||..::::.::                        :.||..::|:.|:.:....|.:..    
Human  3294 IVTIGTDSAICHTPVVAGTSRGFQAQSFIATLKYLDVKHKEHPNRIHISVQIPHQDGMLPL---- 3354

  Fly 15972 NFTIYDKIRIELEAIILFKLNQILENLKATKSTPACIDHYKYIAKNLVTSLAMSNTEKWNVIRKS 16036
                       :..:.|..|:.:|..         .|..::::..||||:..:..      |.::
Human  3355 -----------ISTMPLHNLHFLLSE---------SIYRHQHVCSNLVTTYDLRG------ISEA 3393

  Fly 16037 HLICHITQNTTVTKPSL-------PPTTQTSTV--------SKTMGGFAAYYCNQQIMNLVVIKY 16086
            ..:..:..::|...|..       |...:..|:        ...:..|.|||...::::      
Human  3394 GFLDDVVYDSTALGPGYDRPFQFDPSVREPKTIQLYKHLNLKSCVWTFDAYYDMTELID------ 3452

  Fly 16087 SLSPNNETIPISPKDPCTSIL----------------QKISQAHQHNDSSHSAEFDNIIGKINTA 16135
             :...:.|.....:|...|.|                :..:....|.:...|..:|.::.:  |.
Human  3453 -VCGGSVTADFQVRDSAQSFLTVHVPLYVSYIYVTAPRGWASLEHHTEMEFSFFYDTVLWR--TG 3514

  Fly 16136 IKEDWITNKKALLIREY--------LEFEKLRKY-----LDHILAGKIE------------ECDM 16175
            |:.|.:.:.:..:||.|        :||:...|:     ::|....:::            |.|:
Human  3515 IQTDSVLSARLQIIRIYIREDGRLVIEFKTHAKFRGQFVMEHHTLPEVKSFVLTPDHLGGIEFDL 3579

  Fly 16176 RLAVVKSRKCWNYYTKLKVMF---HKAMQETSA--RKQY 16209
            :|       .|:..|     |   |:..:.||:  ||.|
Human  3580 QL-------LWSAQT-----FDSPHQLWRATSSYNRKDY 3606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Muc14ANP_727928.3 PRK14949 <11377..11776 CDD:237863
PRK08581 11922..>12215 CDD:236304
PRK14949 <13679..14114 CDD:237863 72/366 (20%)
PRK14949 <14663..15055 CDD:237863 94/497 (19%)
FRAS1NP_079350.5 VWC 28..87 CDD:214564
VWC 95..152 CDD:278520
VWC 159..216 CDD:278520
VWC 221..278 CDD:278520
VWC 285..342 CDD:214564
VWC 367..416 CDD:214564
FU 1 409..460
Furin-like 462..620 CDD:279142
FU 2 462..505
FU 462..504 CDD:214589
FU 3 507..553
FU 507..552 CDD:214589
FU 4 555..599
FU 556..598 CDD:214589
FU 5 602..647
FU 608..653 CDD:238021
FU 6 649..705
FU 650..704 CDD:214589
GF_recep_IV 655..777 CDD:291509
FU 7 708..753
FU 708..752 CDD:214589
FU 8 755..800
FU 755..799 CDD:214589
FU 9 803..852
FU 804..851 CDD:214589
Furin-like 841..1056 CDD:279142
FU 10 854..900
FU 859..907 CDD:238021
FU 11 903..948
FU 12 952..997
FU 952..996 CDD:214589
FU 13 999..1042
FU 999..1041 CDD:214589
Furin-like_2 1009..1099 CDD:292535 4/11 (36%)
FU 14 1046..1089 1/1 (100%)
FU 1046..1087 CDD:214589 515/2899 (18%)
Cadherin_3 <1101..1183 CDD:292802 14/85 (16%)
CSPG 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1102..1197 15/98 (15%)
Cadherin_3 1168..1310 CDD:292802 29/163 (18%)
CSPG 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1217..1308 20/97 (21%)
Cadherin_3 1279..1438 CDD:292802 38/190 (20%)
CSPG 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1329..1438 26/127 (20%)
Cadherin_3 1409..1574 CDD:292802 38/199 (19%)
CSPG 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1463..1559 23/127 (18%)
Cadherin_3 1529..1691 CDD:292802 31/195 (16%)
CSPG 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1595..1689 16/122 (13%)
Cadherin_3 1660..1811 CDD:292802 35/205 (17%)
CSPG 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1710..1810 25/127 (20%)
Cadherin_3 1778..1938 CDD:292802 30/161 (19%)
CSPG 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1833..1936 18/102 (18%)
Cadherin_3 1904..2059 CDD:292802 34/186 (18%)
CSPG 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1957..2057 20/130 (15%)
Cadherin_3 2028..2179 CDD:292802 28/157 (18%)
CSPG 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2078..2177 21/105 (20%)
Cadherin_3 2147..2293 CDD:292802 35/165 (21%)
CSPG 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2199..2291 21/103 (20%)
Cadherin_3 2261..2406 CDD:292802 31/149 (21%)
CSPG 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2311..2404 17/97 (18%)
Cadherin_3 2375..2537 CDD:292802 39/209 (19%)
CSPG 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2439..2536 27/141 (19%)
Calx_beta 2555..2650 CDD:197594 18/103 (17%)
Calx-beta 2675..2764 CDD:295344 13/96 (14%)
Calx-beta 2798..2894 CDD:295344 17/108 (16%)
Calx-beta 2920..3011 CDD:295344 17/100 (17%)
Calx-beta 3039..3133 CDD:295344 19/102 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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